The race for antimicrobials in the multidrug resistance era

Molina-Santiago, Carlos; Vicente, Antonio de; Romero, Diego

doi:10.1111/1751-7915.12884

Cited by 4 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Symbion microorganisms have the potential to produce secondary metabolites to protect host organisms, as a defense against pathogenic microorganisms, and for the purposes of interspecies communication [26]. Some luminescent microorganisms are reported to have antimicrobial properties, although so far luminescent microorganisms have not been explored as new potential for sources of antimicrobial agents for sources of antimicrobial agents for emerging global threats of multi drug resistant microorganisms [27]. showing antimicrobial activity against one pathogenic bacterium with inhibition zones ranging from 7 to 25 mm.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Isolation and Identification of Symbiont Microorganisms from Bioluminescent Marine Life

Pringgenies

Dewi

Apriliyani

2019

ARRB

View full text Add to dashboard Cite

Bioluminescence means the ability of animals or plants to naturally produce light. The three known ways by which bioluminescence is produced are through specific cells called photocytes, bioluminescent glands in tissues and symbiotic bioluminescent microorganisms. Bioluminescence in Loligo duvaucelii is known to be caused by the presence of symbiotic microorganisms in bioluminescent sacs. There is a need to compile more information on bioluminescent symbiotic microorganisms on marine life in Indonesia and their potential. This study aims to determine the species of bioluminescent microorganisms on squid and fish, namely Loligo sp. and Loligo edulis from the waters of Jepara and the Bombay duck (Harpadon nehereus) from the Strait of Malacca, Indonesia and their potential. The samples were collected by isolating the microorganisms from the luminescent organs, after which the bioluminescent microorganisms were used in the research. This research consisted of antimicrobial tests against pathogenic microorganisms which were conducted qualitatively. The bioluminescent microorganisms were identified using biochemical assay and molecular assay (16S rRNA PCR). Tests results from Loligo sp. symbiotic microorganisms found two isolates which showed antimicrobial activities against pathogenic Multi Drug Resistant (MDR) microorganisms, namely uncultured bacterium clone 1P-1-G05 against Escherichia coli with 32.59 mm of inhibitory zone and Uncultured bacterium clone 3g10a against Enterobacter sp. with 28.44 mm of inhibitory zone. The bioluminescent symbiont microorganisms in Loligo edulis, which was identified to be Photobacterium phosphoreum, showed antimicrobial activities against Vibrio harveyi, E. coli, Staphylococcus aureus, and Bacillus sp. Bioluminescent symbiotic microorganisms on H. nehereus identified Alteromonas macleodii, which showed gamma hemolysis on the blood agar test.

show abstract

Section: Discussionmentioning

confidence: 99%

“…(93%), and uncultured bacterium clone F2G (89%). The luminescent microorganisms also have the ability as antibacterial against MDR microorganisms S. aureus and K. pneumonia [27].…”

Section: Discussionmentioning

confidence: 99%

Isolation and Identification of Symbiont Microorganisms from Bioluminescent Marine Life

Pringgenies

Dewi

Apriliyani

2019

ARRB

View full text Add to dashboard Cite

show abstract

“…In recent years, there has been a growing interest in research and development of new antimicrobial agents to combat microbial resistance. All of the most important groups of antibiotics (tetracyclines, cephalosporins, aminoglycosides and macrolides) were discovered in the 1960s and these compounds are in danger of losing their efficacy because of the increase in microbial resistance [ 20 ], due especially to the emergence of multidrug-resistant bacteria [ 21 , 22 , 23 ]. For this reason, the discovery of new antibiotics is one of the main objectives of medicine nowadays [ 24 ].…”

Section: Methodologies Of Screeningmentioning

confidence: 99%

Current Screening Methodologies in Drug Discovery for Selected Human Diseases

et al. 2018

View full text Add to dashboard Cite

The increase of many deadly diseases like infections by multidrug-resistant bacteria implies re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and regulation of diseases, the increase in knowledge based on the study of disease-born microorganisms’ genomes, the development of more representative disease models and improvement of techniques, technologies, and computation applied to biology are advances that will foster drug discovery in upcoming years. In this paper, several aspects of current methodologies for drug discovery of antibacterial and antifungals, anti-tropical diseases, antibiofilm and antiquorum sensing, anticancer and neuroprotectors are considered. For drug discovery, two different complementary approaches can be applied: classical pharmacology, also known as phenotypic drug discovery, which is the historical basis of drug discovery, and reverse pharmacology, also designated target-based drug discovery. Screening methods based on phenotypic drug discovery have been used to discover new natural products mainly from terrestrial origin. Examples of the discovery of marine natural products are provided. A section on future trends provides a comprehensive overview on recent advances that will foster the pharmaceutical industry.

show abstract

Continuous flow synthesis and antimicrobial evaluation of NHC* silver carboxylate derivatives of SBC3 in vitro and in vivo

et al. 2020

View full text Add to dashboard Cite

N-Heterocyclic silver carbene compounds have been extensively studied and shown to be active agents against a host of pathogenic bacteria and fungi. By incorporating hypothesised virulence targeting substituents into NHC-silver systems via salt metathesis, an atom efficient complexation process can used to develop new complexes to target the passive and active systems of a microbial cell. The incorporation of fatty acids and an FtsZ inhibitor have been achieved, and creation of both the intermediate salt and subsequent silver complex has been streamlined into a continuous flow process. Biological evaluation was conducted with in vitro toxicology assays showing these novel complexes had excellent inhibition against Gram-negative strains E. coli, P. aeruginosa and K. pneumonia; further studies also confirmed the ability to inhibit biofilm formation in Methicillin-resistant S. aureus and C. Parapsilosis. In vivo testing using a murine thigh infection model showed promising inhibition of MRSA for the lead compound SBC3, which is derived from 1,3-dibenzyl-4,5-diphenylimidazol-2-ylidene(NHC*).

show abstract

The race for antimicrobials in the multidrug resistance era

Cited by 4 publications

References 16 publications

Isolation and Identification of Symbiont Microorganisms from Bioluminescent Marine Life

Isolation and Identification of Symbiont Microorganisms from Bioluminescent Marine Life

Current Screening Methodologies in Drug Discovery for Selected Human Diseases

Continuous flow synthesis and antimicrobial evaluation of NHC* silver carboxylate derivatives of SBC3 in vitro and in vivo

Contact Info

Product

Resources

About