The R620W polymorphism of the protein tyrosine phosphatase 22 gene in autoimmune thyroid diseases and rheumatoid arthritis in the Tunisian population

Abstract

Our data suggest that the PTPN22 C1858T single nucleotide polymorphism has no or minor effect on RA and AITDs susceptibility in the Tunisian population.

R620W functional polymorphism of protein tyrosine phosphatase non-receptor type 22 is not associated with pulmonary tuberculosis in Zahedan, southeast Iran

“…Allele frequencies of PTPN22 C1858T in pulmonary tuberculosis (PTB) patients and healthy subjects. (Begovich et al, 2004;Ban et al, 2005;Mori et al, 2005;Chabchoub et al, 2006;Ikegami et al, 2007;Chabchoub et al, 2009). The frequency of the PTPN22-1858T allele in a Chinese population was found to be 1.43% (Zhang et al, 2008).…”

Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue

“…49,[56][57][58][59][60][61][62][63][64][65][66][67] Americans of non-European descent showed a very low T allele frequency, as low as 1.1% in Mexico. 68 North Africa had a similar T allele frequency to Turkey and the Middle East, which ranged from 2 to 3.5%; [69][70][71][72][73][74][75] however, PTPN22 is not polymorphic in the black African population. 76 PTPN22 is also non-polymorphic or almost non-polymorphic in some Asian populations, including Japanese, Korean, Indian and some Chinese populations.…”

“…Only a few studies have been conducted in other populations such as North African, Turkish, Mexican and Indian, and then with only a small number of samples. [70][71][72]74,75,83,84 Therefore, to avoid any possible heterogeneity, we excluded these studies and focused on studies in European or European-descended populations.…”

Association of Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) C1858T gene polymorphism with susceptibility to autoimmune thyroid diseases: a meta-analysis

“…18 21-3.33). Since a large part of the analyzed studies investigated the China, UK, Germany and others populations, we also performed a stratified analysis by country, dividing the groups in China, UK, Germany and others.…”

“…Via an extensive search, eleven eligible articles [3,7,[16][17][18][19][20][21][22][23][24] were selected for this meta-analysis, including 3764 AITD cases and 3328 controls. Study characteristics were summarized in Table 1.…”