The question of the content of arctiin in the seeds of Arctium leiospermum

Yakhontova, L. D.; Kibal'chich, P. N.

doi:10.1007/bf00569000

Cited by 4 publications

(1 citation statement)

References 2 publications

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“…The chemical composition of Arctium lappa has been the most studied so far, while Arctium leiospermun, Arctium minus and Arctium tomentosum have been studied only partly. The chemical composition of the other species has not been studied yet [2,7,[14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Chromatographic and Spectral Study of Arctium Lappa and Arctium Tomentosum Fructus Cultivated in Altai

Kolomiets,

Boev,

Zhalnina

et al. 2024

JCPRM

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Burdock is an ingredient of official and traditional medicines in different countries, its roots are used for food, biologically active additives, functional nutrition products, fertilizers, etc. A great demand led to the situation when many countries including Russia began the plant’s cultivation. Despite that, the aboveground parts of the plant including its fructus still remain expendable. At the moment, burdock fructus are officially used only in China and Japan. In Russia they are not used and studies of their chemical composition and pharmacological properties are scarce. The research showed that fructus of Arctium lappa and A. tomentosum cultivated in Altai using by traditional way of growing, and new of agrotechnics of cultivation contain lignans, hydroxycinamic acid, fatty acids and their derivatives, polysaccharides and anthocyanin’s. The use of a new cultivation technology increased the content of lignans and other BAS by 10–25%. Hydroxycinamic acid is one of the dominant substances in fructus by content, therefore it is possible to standardize raw material according to this parameter. The presence of methyl cis-9, cis-15-octadecadienoate and 11-Eicosenoic acid methyl ester in fructushas been discovered for the first time. Ethyl linoleate and methylfolate or methyl cis-9-octadecenoate are found to be dominant components of fatty acids and their derivatives. Additional studies of chemical composition, pharmacological properties, clinical approbation are needed to obtain evidence of the efficiency of burdock fructus utilization for clinical purposes and prevention.

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Section: Introductionmentioning

confidence: 99%

Chromatographic and Spectral Study of Arctium Lappa and Arctium Tomentosum Fructus Cultivated in Altai

Kolomiets,

Boev,

Zhalnina

et al. 2024

JCPRM

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Phytochemical Examination of Woolly Burdock Arctium tomentosum Leaves and Flower Heads

et al. 2020

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Therapeutic Effect of Arctiin and Arctigenin in Immunocompetent and Immunocompromised Mice Infected with Influenza A Virus

Hayashi

Narutaki

Nagaoka

et al. 2010

Biological & Pharmaceutical Bulletin

141

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Arctiin and its aglucone, arctigenin from the fruits of Arctium lappa L. showed potent in vitro antiviral activities against influenza A virus (A/NWS/33, H1N1) (IFV). Based on the data from time-of-addition experiments and on release tests of progeny viruses, arctigenin was assumed to interfere with early event(s) of viral replication after viral penetration into cells, and to suppress the release of progeny viruses from the host cells. Arctiin was orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice, being less effective as compared with oseltamivir. Noticeably, arctiin produced a larger amount of virus-specific antibody than those of control and oseltamivir in sera collected from 5-FU-treated mice. Furthermore, oral treatment of 5-FU-treated mice with arctiin did not induce any resistant viruses, although the same treatment with oseltamivir induced resistant viruses at a 50% frequency. When the combination of arctiin and oseltamivir was administered to normal mice infected with IFV, the virus yields in both bronchoalveolar lavage fluids and lungs were significantly reduced relative to those in the mice treated with arctiin or oseltamivir alone. Thus, monotherapy of arctiin or combined therapy of arctiin with oseltamivir would be another treatment option for influenza.

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The question of the content of arctiin in the seeds of Arctium leiospermum

Cited by 4 publications

References 2 publications

Chromatographic and Spectral Study of Arctium Lappa and Arctium Tomentosum Fructus Cultivated in Altai

Chromatographic and Spectral Study of Arctium Lappa and Arctium Tomentosum Fructus Cultivated in Altai

Phytochemical Examination of Woolly Burdock Arctium tomentosum Leaves and Flower Heads

Therapeutic Effect of Arctiin and Arctigenin in Immunocompetent and Immunocompromised Mice Infected with Influenza A Virus

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