The quantra hemostasis analyzer compared to thromboelastography (TEG) in the surgical oncologic population: A prospective observational trial

Abstract

Background Management of coagulopathy during major oncologic surgery can be multifactorial and challenging. Viscoelastic assays (VEAs) can be useful in providing vital data about the mechanism of coagulopathy in these dynamic circumstances. Objectives A prospective nonrandomized observational study with the aim of describing the coagulation parameters of patients undergoing major oncologic surgery using the Quantra® and TEG® 5000 systems. Our secondary objectives included the correlation between Quantra and TEG parameters, and the times to result for both technologies. Methods This study included 74 adults undergoing oncologic surgery with an anticipated blood loss of more than 500 ml. For each subject, whole blood samples for each device were collected at multiple points perioperatively for comparison. Results Correlation coefficients between Quantra and TEG parameters were 0.8 and above, indicating a very strong correlation (p < .001). Correlation coefficients between conventional laboratory tests and Quantra ranged from 0.74 to 0.83, indicating a moderate correlation (p < .001). The mean time to obtain results and total processing time was shorter for Quantra in comparison to TEG. Conclusions Quantra parameters strongly correlated with TEG parameters; however, Quantra parameters were available in shorter amount of time as it is specifically designed as a closed point of care device.

Thromboelastography-Guided Therapy Enhances Patient Blood Management in Cirrhotic Patients: A Meta-analysis Based on Randomized Controlled Trials

“…40 Although thromboelastography has been the most frequently used technology in liver cirrhosis RCTs, as shown by recent meta-analyses of viscoelastic testing, 39,43 RCT evidence is also emerging for rotational thromboelastometry. Studies in other therapeutic areas have demonstrated correlation between parameters and clinical outcomes between viscoelastic testing devices, [44][45][46] and so it would be expected that studies in cirrhosis with comparable study designs conducted with other technologies would show similar results to those using thromboelastography. Nevertheless, since most of the available RCT data relate to thromboelastography, further studies with rotational thromboelastometry and other technologies are warranted.…”