The quantitative relationship between longitudinal and radial function in left, right, and total heart pumping in humans

Carlsson, Marcus; Ugander, Martin; Heiberg, Einar; Arheden, Håkan

doi:10.1152/ajpheart.01376.2006

Cited by 172 publications

(195 citation statements)

References 37 publications

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“…4 Using TEE, the tricuspid annular motion aligns with the Doppler plane only in the modified transgastric inflow-outflow view. 7 Tricuspid annular systolic plane excursion by TT measured in this area did not result in any correlation with SV (r = 0.09). This may be the result of its proximity to the septum and left ventricle or simply that longitudinal annular motion in this location does not fully represent RV function.…”

Section: Discussionmentioning

confidence: 78%

“…The longitudinal contribution to total RV output has been shown to be approximately 80% owing to a predominantly longitudinal muscle fibre orientation. [7][8][9] For this reason, TAPSE, a measure of longitudinal displacement, has become popular in the rapid and simple assessment of RV function. [10][11][12] Tricuspid annular systolic plane excursion is independent of age, sex, and body size 11 ; however, it remains dependent on LV function.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of TAPSE as a measure of right ventricular output

Tousignant

Kim

Papa

et al. 2012

Can J Anesth/J Can Anesth

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Purpose This study was designed to show the relationship between tricuspid annular plane systolic excursion (TAPSE) and stroke volume (SV) by thermodilution using three different methods and also to assess whether TAPSE can track hemodynamic changes associated with volume loading and ephedrine administration. Methods This was an observational study in 61 elective patients with a pulmonary artery catheter who were undergoing coronary artery bypass graft surgery in a cardiac surgical centre. We measured TAPSE by three methods using transesophageal echocardiography: M mode, speckle tracking at the lateral wall, and tissue tracking at the inferior wall. There were two interventions: leg raising (volume recruitment) or administration of ephedrine 5 mg iv. Echo and hemodynamic measurements were performed before and after each intervention.Results Eleven patients were excluded due to poor imaging. There were 26 patients in the leg raising group and 24 patients in the ephedrine group. The correlation coefficient between stroke volume (SV) and TAPSE by M mode, speckle tracking, and tissue tracking was 0.48, 0.44, and 0.09, respectively. There was a significant increase in SV following each intervention; however, the changes in TAPSE by any method and velocity were not large enough to reach statistical significance. Conclusion Tricuspid annular plane systolic excursion by M mode and by speckle tracking correlates modestly with SV. There was no correlation between TAPSE and SV by tissue tracking at the inferior wall of the right ventricle. Tricuspid annular plane systolic excursion by M mode and by speckle tracking does not track changes in SV following either volume loading or ephedrine administration. RésuméObjectif Cette e´tude a e´te´conçue pour montrer le rapport entre le de´placement systolique du plan de l'anneau tricuspidien (TAPSE) avec le volume d'e´jection systolique (SV) par thermodilution en utilisant trois me´thodes diffe´rentes et aussi pour de´terminer si le TAPSE peut suivre les modifications he´modynamiques associe´es a`une charge volumique et a`une administration d'e´phe´drine. Méthodes Il s'agit d'une e´tude observationnelle mene´e chez 61 patients se´lectionne´s porteurs d'un cathe´ter de l'arte`re pulmonaire qui devaient subir un pontage coronarien dans un centre de chirurgie cardiaque. Nous avons mesure´le TAPSE par trois me´thodes diffe´rentes al 'aide d'une e´chocardiographie transoesophagienne: mode M;suivi de granularite´s (speckle tracking) sur la paroi late´rale; et suivi de tissu (tissue tracking) sur la paroi infe´rieure. Il y a eu deux interventions: jambes releve´es

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Evaluation of TAPSE as a measure of right ventricular output

Tousignant

Kim

Papa

et al. 2012

Can J Anesth/J Can Anesth

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“…Although it did not prevent the reduced longitudinal systolic strain commonly observed in HFpEF patients,40, 41, 42 which is known to correlate with higher LV filling pressures, lower cardiac output, and worse New York Heart Association functional class,40 treatment with saxagliptin attenuated or prevented alterations to LV systolic function at the whole heart and cellular level observed in the HF group. Attenuation of the heightened contractile state often seen under resting conditions in HFpEF may be due to the preservation or improvement of normal LV diastolic cellular mechanics, myocardial collagen deposition, mitochondrial function, and cardiomyocyte diastolic function in HF‐SAX animals despite an increase in the EDPVR.…”

Section: Discussionmentioning

confidence: 80%

Saxagliptin and Tadalafil Differentially Alter Cyclic Guanosine Monophosphate (cGMP) Signaling and Left Ventricular Function in Aortic‐Banded Mini‐Swine

Hiemstra

Lee

Chakir

et al. 2016

JAHA

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BackgroundCyclic guanosine monophosphate‐protein kinase G‐phosphodiesterase 5 signaling may be disturbed in heart failure (HF) with preserved ejection fraction, contributing to cardiac remodeling and dysfunction. The purpose of this study was to manipulate cyclic guanosine monophosphate signaling using the dipeptidyl‐peptidase 4 inhibitor saxagliptin and phosphodiesterase 5 inhibitor tadalafil. We hypothesized that preservation of cyclic guanosine monophosphate cGMP signaling would attenuate pathological cardiac remodeling and improve left ventricular (LV) function.Methods and ResultsWe assessed LV hypertrophy and function at the organ and cellular level in aortic‐banded pigs. Concentric hypertrophy was equal in all groups, but LV collagen deposition was increased in only HF animals. Prevention of fibrotic remodeling by saxagliptin and tadalafil was correlated with neuropeptide Y plasma levels. Saxagliptin better preserved integrated LV systolic and diastolic function by maintaining normal LV chamber volumes and contractility (end‐systolic pressure‐volume relationship, preload recruitable SW) while preventing changes to early/late diastolic longitudinal strain rate. Function was similar to the HF group in tadalafil‐treated animals including increased LV contractility, reduced chamber volume, and decreased longitudinal, circumferential, and radial mechanics. Saxagliptin and tadalafil prevented a negative cardiomyocyte shortening‐frequency relationship observed in HF animals. Saxagliptin increased phosphodiesterase 5 activity while tadalafil increased cyclic guanosine monophosphate levels; however, neither drug increased downstream PKG activity. Early mitochondrial dysfunction, evident as decreased calcium‐retention capacity and Complex II‐dependent respiratory control, was present in both HF and tadalafil‐treated animals.ConclusionsBoth saxagliptin and tadalafil prevented increased LV collagen deposition in a manner related to the attenuation of increased plasma neuropeptide Y levels. Saxagliptin appears superior for treating heart failure with preserved ejection fraction, considering its comprehensive effects on integrated LV systolic and diastolic function.

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“…Due to the longitudinal fiber orientation of the RV cardiomyocytes, the resulting RV systolic wall motion is predominantly longitudinal [40]. Thus, the base of the ventricle (annular plane) moves apically, while the active inward motion is minimal and predominantly a result of tethering/traction at the LV insertion sites [41].…”

Section: Tissue Deformation Imagingmentioning

confidence: 99%