The quantitative investigation of spark plasma on skin parameters with skin elasticity, thickness, density, and biometric characteristics

Abstract

Cold atmospheric plasma has been developed and utilized as a novel technique for skin rejuvenation because of its various effects on cells and living things. This study investigated the accuracy of this claim and any possible side effects of using spark plasma to rejuvenate skin. The present work is the first quantitative investigation using animal models. 12 Wistar rats were divided into two groups for this investigation. To compare the skin's natural process with the treated skin, the first group underwent a single session of plasma therapy, while the second group served as the control group. The back of the necks of the samples was shaved for 20 cm. Before beginning treatment, the MPA9 multifunctional skin tester was used to determine the melanin index, erythema index, and transepidermal water loss (TEWL). The skin's thickness and density were assessed using sonography, and its elasticity index was calculated using a Cutometer. The samples were exposed to plasma radiation in the designated area (in a triangular pattern). The abovementioned signs were examined immediately after the following therapy and at the weekly appointment 2–4 weeks later. Optical spectroscopy was also used to demonstrate the presence of active species. In this study, we found that a plasma spark therapy session significantly boosts skin elasticity, and the ultrasound results revealed a significantly increased skin thickness and density. The plasma increased the amount of skin surface evaporation, erythema, and melanin immediately following the treatment. However, 4 weeks later, it recovered to its former state and did not differ significantly from before the therapy.

Comparing the efficacy of plasma exeresis and cryotherapy for the treatment of seborrheic keratosis: A randomized controlled trial

“…The plasma exeresis medical devices ionize the atmospheric gas between the device and the skin, sublimate the surface layers, and uniformly heat it. [9][10][11] Plasma exeresis is an innovative, minimally invasive technique that has been gaining attention in dermatology. Plasma has been widely used in treating moles, telangiectasia, stretch marks, acne scars, skin rejuvenation, and skin tightening.…”

“…In a study done by Ghasemi et al, investigating the effect of plasma exeresis on skin parameters on rat models, it was concluded that plasma exeresis improves skin thickness, density, and elasticity, most likely due to increased keratinocytes and fibroblasts. 9 In one study conducted by Rossi et al, the efficacy of using plasma was evaluated in 250 patients with benign skin lesions (dermal nevi, fibroma, keratosis, xanthelasma), nonsurgical blepharoplasty, wrinkles (perioral, glabellar, neck, and preauricular regions), active acne, and scarring (postacneic and posttraumatic). The results revealed that plasma exeresis is extremely reliable and safe, without having any permanent side effects.…”

“…Recent studies have shown the efficacy of this technology for the treatment of various dermatologic indications including perioral wrinkles, acne, and nonsurgical blepharoplasty. 9,10,12,13 The aim of the current study is to compare the efficacy and safety of plasma exeresis and cryotherapy for the treatment of SK.…”

“…The plasma exeresis medical devices generate plasma energy by ionizing atmospheric gas between the device and the skin. [9][10][11] The resulting plasma exeresis sublimates the surface layers and transfers the stored heat energy to the skin surface. Recent studies have shown the efficacy of this technology for the treatment of various dermatologic indications including perioral wrinkles, acne, and nonsurgical blepharoplasty.…”

Quantitative comparison of spark plasma's influence on parameters affecting rejuvenation of the skin at two different voltages

“…However, studies show that NO signi cantly impacts the skin, speci cally on the proliferation of keratinocytes and broblasts [16], [22], [26] Epidermis thickening brought on by cold plasma is most likely caused by the proliferation of keratinocytes [16], [22], [26]. However, CAP can initially weaken the skin barrier and dry up the top layer of the epidermis.…”