The Quantitative Genetics of Human Disease: 2 Polygenic Risk Scores
David J. Cutler,
Kiana Jodeiry,
Andrew J. Bass
et al.
Abstract:In this the second of an anticipated four papers, we examine polygenic risk scores from a quantitative genetics perspective. In its most simplistic form, a polygenic risk score (PRS) analysis involves estimating the genetic effects of alleles in one study and then using those estimates to predict phenotype in another sample of individuals. Almost since the first application of these types of analyses it has been noted that PRSs often give unexpected and difficult-to-interpret results, particularly when applyin… Show more
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