The quantitative analysis of the polyester components of crosslinked silicone-polyester-aminoformaldehyde condensation products

Haken, J.K.; Harahap, N.; Burford, R. P.

doi:10.1016/0033-0655(89)80029-9

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2006

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Cited by 5 publications

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“…Siloxanes have low toxicity, low surface tension, low flammability and a high thermal stability,30 but are perhaps more prone toward depolymerization than common perceptions would allow 31,32. Permethylsilicone polymers can readily decompose in the environment to dimethylsilanediol monomers,32,33 and they also depolymerize and dissolve in aqueous base 34,35. Moreover, rates of silanediol self‐condensation drop as the organic groups increase in size 36.…”

Section: Introductionmentioning

confidence: 99%

Silanediol Protease Inhibitors: From Conception to Validation

2006

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Keywords: Drug design / Hydrolases / Inhibitors / Peptidomimetics / Proteases / Silanes / Silicon Silanediols are isosteric with the unstable hydrated carbonyl group, but are most commonly associated with polymerization to give silicone polymers. Placement of a silanediol in a dipeptide analogue yields a new kind of nonhydrolyzable transition-state-analogue protease inhibitor. Both metallo and aspartic protease inhibitors have been prepared using silanediols, with enzyme inhibition in the low nanomolar range. Structure-activity comparisons with known inhibitors,

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