The quality of life of people who have chronic wounds and who self‐treat

Kapp, Suzanne; Miller, Charne; Santamaria, Nick

doi:10.1111/jocn.13870

Cited by 88 publications

(124 citation statements)

References 33 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…Skin trauma will destroy the barrier function of the skin, weaken normal functions and even induce skin tumors . Although most skin traumas are self‐healing, promoting the closure of skin wound by pharmacological means is beneficial to shortening the course of the wound, reducing the risk of systemic infection and satisfying the cosmetic needs of the patients . Therefore, it is one of the hot topics in clinical research to seek candidate agents or methods to promote skin wound healing.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

Hua

et al. 2019

Experimental Dermatology

View full text Add to dashboard Cite

Hydrogen sulphide (H2S) is an important gasotransmitter with several physiological functions. However, the roles and the detailed mechanisms of H2S on skin wound healing are not known well. In the present study, 129S1/SvImJ mice were intraperitoneally injected with NaHS (50 μmol/kg/d) for 2 weeks. Then, a round wound of 6 mm diameter with depth into the dermis was made. The skin wound area, blood perfusion, superoxide production, malondialdehyde (MDA) levels, total antioxidant capacity (T‐AOC), expression of vascular endothelial growth factor (VEGF), dynamin‐related protein 1 (DRP1) and optic atrophy 1 (OPA1) were measured. After NaHS (50 μmol/L) pre‐administration for 4 hours, cell migration rate, DRP1, OPA1 and α–smooth muscle actin (α‐SMA) expression, superoxide production and mitochondrial membrane potential in primary skin fibroblasts were measured. Tube formation in human umbilical vein endothelial cells (HUVECs) and cell migration in human keratinocytes were also measured. The results showed that NaHS pretreatment significantly accelerated wound healing and improved blood flow in the wound after operation. NaHS increased VEGF expression in the wound and promoted tube formation in HUVECs. Meanwhile, NaHS attenuated reactive oxygen species (ROS) production, suppressed MDA level but restored T‐AOC in the wound. NaHS also promoted skin fibroblasts migration and α‐SMA expression after scratch. Moreover, NaHS alleviated ROS, increased mitochondrial membrane potential, decreased DRP1 but enhanced OPA1 expression in skin fibroblasts after scratch. NaHS also accelerated human keratinocytes migration after scratch. Taken together, exogenous H2S supplementary accelerated the skin wound healing, which might be related to oxidative stress inhibition and VEGF enhancement.

show abstract

Section: Introductionmentioning

confidence: 99%

“…beneficial to shortening the course of the wound, reducing the risk of systemic infection and satisfying the cosmetic needs of the patients. [4] Therefore, it is one of the hot topics in clinical research to seek candidate agents or methods to promote skin wound healing.…”

mentioning

confidence: 99%

Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

Hua

et al. 2019

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…The psychosocial effects of chronic wounds include emotional distress because of pain and withdrawal from social and work activities, and must be considered within a holistic patient assessment (Pragnell andNeilson 2010, Dowsett andvon Hallern 2017). Kapp et al's (2018) study of 25 adult patients with chronic wounds found that they all experienced adverse psychosocial effects, such as an inability to exercise or socialise as they had previously, disrupted employment and increased financial pressures resulting from wound dressing and care costs. Other studies have detailed the emotional implications of chronic wounds, particularly where wound pain and pain during dressing changes negatively affected patients' psychological well-being (Pragnell andNeilson 2010, Upton et al 2012).…”

Section: Psychosocial Factorsmentioning

confidence: 99%

“…Other studies have detailed the emotional implications of chronic wounds, particularly where wound pain and pain during dressing changes negatively affected patients' psychological well-being (Pragnell andNeilson 2010, Upton et al 2012). Kapp et al (2018) also identified that patients with chronic wounds could become frustrated and distrustful of healthcare staff because of the complexity and variation in their opinions regarding effective treatments. As a result of these factors, nurses may encounter an understandable reluctance on the part of patients with chronic wounds to continue with | PEER-REVIEWED | skin care / evidence & practice treatment (Upton et al 2012, Kapp et al 2018.…”

Section: Psychosocial Factorsmentioning

confidence: 99%

Undertaking a person-centred assessment of patients with chronic wounds

Smith

Sharp

2019

Nursing Standard

View full text Add to dashboard Cite

Wounds have traditionally been classified as acute or chronic. While this classification is useful when attempting to estimate healing times, it might lead to an acceptance that some wounds will take longer to heal or might not heal at all. Chronic wounds can adversely affect patients' quality of life, and the management of these wounds may involve significant healthcare resources and costs. Chronic wounds rarely develop in healthy individuals and are often associated with pre-existing conditions that complicate wound healing, such as diabetes mellitus and vascular disease. This article discusses how acute wounds and chronic wounds are differentiated. It details the phases of wound healing and identifies potential barriers to progression through these phases. Enhancing nurses' understanding of chronic wounds will enable them to identify any potential barriers to wound healing early and remove or ameliorate them. While a holistic assessment should also include a thorough assessment of the wound itself, this is beyond the scope of this article.

show abstract

“…Chronic wound is de ned as a wound that has failed to achieve anatomical and functional integrity through orderly and timely repair within 3 months (17), and is prevalent in the population with the number of patients increasing year by year (18)(19)(20). Besides similar to the COVID-19, the middle-aged population and diabetics are at high risk of chronic wounds (11,18,21). Although wound non-healing is considered multifactorial in nature (17), infection and microbial implantation may be the single most likely and unavoidable cause of delayed wound healing (22,23), and without timely and effective treatment, bacterial implantation in the body can lead to systemic infection or even life-threatening infection (24,25).…”

Section: Introductionmentioning

confidence: 99%

Exposure risk of patients with chronic infectious wounds during the COVID-19 outbreak and its countermeasures

Zhou

Jin

Lü

2020

Preprint

View full text Add to dashboard Cite

BACKGROUND A large number of cases of pneumonia caused by novel β-coronavirus emerged in Hubei Province, China, at the end of 2019 and demonstrated great potential for transmission. At present, known independent risk factors include age, diabetes and other chronic diseases, which may be similar to the patients with chronic wound, thus we try to explore the clinical characteristics, prognostic factors and management recommendation of patients with chronic infective wounds during the COVID-19 epidemic period. METHODS In this single-center, retrospective observational study, we included all cases with chronic infective wounds that came to our hospital between the full outbreak of the COVID-19 in China (January 23, 2020) and the latest date prior to posting (20 April 2020). Demographic data, comorbidities, laboratory and imaging findings, consultation history and clinical outcomes (lesion cured, uncontrolled, amputated, etc. as of May 10, 2020) were collected for all individuals. Patients were subdivided into gangrene, traumatic infection and other types of soft tissue infection wound (including bedsores, gout ruptures, stab wounds and so on) according to the causes of wound and their disease-related information were compared group by group. RESULTS Among the total 81 patients with chronic infective wounds, 60% was male, with a mean age of 60.8 years (SD 18.6), including 38 (47%) patients with traumatic infection, 29 (36%) gangrene cases, and 14 (17%) other soft tissue infection wounds. Common comorbidities are hypertension (32%), diabetes (32%), cardiovascular disease (24%), and kidney injury (12%), and the patients with gangrenes have the most comorbidities. As of May 10, 2020, there were 78 patients discharged and their average stay time is 15.8 days(SD 14.2), while people still at the hospital is 39.7days(SD 8.7)much longer than the discharged and also has more comorbidities. But there is no significant difference in the hospitalization time of three types of wounds. And fortunately, none of all the patients were infected by coronavirus. CONCLUSION The majority of patients with chronic wounds are severely ill with high risk of infection and poor prognosis, therefore management of patients with chronic wounds should be improved.

show abstract

The quality of life of people who have chronic wounds and who self‐treat

Cited by 88 publications

References 33 publications

Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

Undertaking a person-centred assessment of patients with chronic wounds

Exposure risk of patients with chronic infectious wounds during the COVID-19 outbreak and its countermeasures

Contact Info

Product

Resources

About