The quality of life of comorbid patients with pathology of thyroid gland and gastroesophageal reflux disease

Abstract

Introduction In Russia, the prevalence of GERD is 18-46% [Ivashkin V. T., Maev I. V., Trukhmanov A. S., 2011]. GERD leads to a significant decrease in the quality of life of patients, especially with nocturnal symptoms, extraesophageal symptoms (chest pain, persistent cough), and increases the risk of complications such as bleeding from ulcers and erosions, peptic strictures and, which causes the greatest caution, Barrett’s esophagus and esophageal adenocarcinomasObjectivesThe medical and social significance of the pathology of the thyroid gland and gastrointestinal tract problem is determined by their high prevalence regardless of age, the annual increase in morbidity and the decrease in the quality of life (QOL).MethodsPatients were divided in two groups: patients with GERD; patients with GERD and hypothyroidism. Quality of life was studied using the non-specific (general) SF 36 questionnaire.ResultsThe lowest indicators were shown by patients with GERD and hypothyroidism (PF scale - Me 75.00 and 45.00 (p=0.005470), RF scale - 75,00 and 25.00 (p=0.043046), BP scale - 74.00 and 52.00 (p=0.036493), GH scale - 58.00 and 15.00 (p=0.009959)). The second group was more disadvantaged (VT scale - IU 52.50 and 32.50 (p=0.098125), SF scale - 75 00 and 50.00 (p=0.019016), RE scale - 33.30 and 0.00 (p=0.028841), GH scale - 48.00 and 36.00 (p=0.025919).ConclusionsAccording to the results, the presence of combined pathology of the thyroid gland and gastrointestinal tract significantly affected the physical and psychological component of health in the studied patients.

Study of the functional state of the thyroid gland in pregnant women with hypothyroidism

“…Many scientists have conducted studies on hypothyroidism [9][10][11][12], with one study recommending regular screening of thyroid function in the first trimester of pregnancy, as it provides an effective way to detect gestational thyroid dysfunction [13].…”