The QSAR study of flavonoid-metal complexes scavenging  OH free radical

Wang, Bochu; Qian, Jueshi; Fan, Ying; Tan, Jun

doi:10.1016/j.molstruc.2014.06.051

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…Both Hesperidin and coumarin have antioxidant activity and can decrease free radical production (Lin et al, 2008;Nakao et al, 2011). Some natural products have metal chelation and antioxidant activities such as citrus fruits, hesperidin, coumarin, naringin, coumarin, resveratrol, quercetin, naringin, and silymarin (Mokni et al, 2007;Cui et al, 2014;Dong et al, 2014;Wang et al, 2014;Ebrahimzadeh et al, 2015Ebrahimzadeh et al, , 2016Filipsky et al, 2015;Khalili et al, 2015a;Zou et al, 2016;Chen et al, 2018;Jahanshahi et al, 2021). Our results show that hesperidin and coumarin have potential iron chelation activities.…”

Section: Discussionmentioning

confidence: 54%

“…Therefore, it is important to find new drugs for the treatment of AD. Previous studies have shown that some natural products such as hesperidin (PubChem CID: 10621) and coumarin (PubChem CID: 323) have antioxidant and iron chelation activities (Grazul and Budzisz, 2009;Wang et al, 2014). Hesperidin is a flavanone glycoside found in citrus fruits, and coumarin is a phenolic substance composed of the fused benzene and α-pyrone rings, which can be found in citrus fruits and carrots (Bor et al, 2016;Rasouli et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Comparison Between Hesperidin, Coumarin, and Deferoxamine Iron Chelation and Antioxidant Activity Against Excessive Iron in the Iron Overloaded Mice

et al. 2022

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ObjectiveIron accumulation in the brain leads to the development of Alzheimer’s and Parkinson’s diseases. Nowadays, iron chelation therapy is the best way to decrease the side effects of iron and amyloid plaques accumulation. Iron chelators are commonly used for the treatment of Alzheimer’s disease. Previous studies have shown that natural products such as phenol and flavonoid compounds could chelate heavy metals. In the current study, we examined the iron chelation activity of hesperidin and coumarin on the brain tissue of iron-overloaded mice.Methods48 NMRI male mice were divided into eight groups (n = 6). Six groups were treated with iron dextran (100 mg/kg/day) four times a week for 6 weeks. After stopping the injections for a month, five groups of iron-overloaded mice were treated with hesperidin, coumarin, and desferal four times a week subsequent for four subsequent weeks. Finally, the mice were anesthetized, and blood samples were collected from the ventricle of the heart for subsequent examination. The brain tissues were isolated and fixed in the 4% paraformaldehyde solution for Perl’s staining.ResultsThe results show that hesperidin and coumarin could strongly chelate excessive iron from the serum and deposit iron from the brain tissue compared to desferal group. Catalase and super oxidase activity were decreased in the iron-overloaded group, but in the treated group by hesperidin and coumarin, the enzyme’s activity was increased significantly.ConclusionHesperidin and coumarin, as natural products, are powerful options to chelate iron ions and increase the activity of antioxidant enzymes.

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Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Comparison Between Hesperidin, Coumarin, and Deferoxamine Iron Chelation and Antioxidant Activity Against Excessive Iron in the Iron Overloaded Mice

et al. 2022

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“…Moreover, it acts as a chelating agent and its complexes play significant roles in human health . In recent years, great interest has been also shown in interactions between morin–metal complexes and nucleic acids due to potential applications as anticancer drugs …”

Section: Introductionmentioning

confidence: 99%

Ga(III) complex with morin for kidney cancer cell labelling

Sentkowska

Kilian

Kopeć

et al. 2017

Applied Organom Chemis

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The formation of a complex between Ga(III) and morin (3,5,7,2′,4′‐pentahydroxyflavone) was studied. UV–visible, infrared and mass spectroscopies were used to characterize the complex. The stoichiometric ratio for the reaction between metal ion and flavonoid was determined using the methods of Yoe–Jones and Job, which confirmed that a 1:1 Ga–morin complex was formed (estimated binding constant = 2.31 × 104 l mol−1). It was found that the coordination to Ga(III) occurs through the carbonyl oxygen atom and the 3‐OH group of the morin molecule. According to developed conditions, complexation reaction with 68Ga was performed and the complex was used to label kidney cancer cells (CAKI‐1, CAKI‐2, ACHN and 786‐O). The knowledge gained from this study should be useful for the development of new radiopharmaceuticals for diagnostic purposes containing 68Ga.

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Quercetin-Iron Complex: Synthesis, Characterization, Antioxidant, DNA Binding, DNA Cleavage, and Antibacterial Activity Studies

Raza

et al. 2016

J Fluoresc

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Quercetin-iron (II) complex was synthesized and characterized by elemental analysis, ultraviolet-visible spectrophotometry, fourier transform infrared spectroscopy, mass spectrometry, proton nuclear magnetic resonance spectroscopy, thermogravimetry and differential scanning calorimetry, scanning electron micrography and molar conductivity. The low molar conductivity value investigates the non-electrolyte nature of the complex. The elemental analysis and other physical and spectroscopic methods reveal the 1:2 stoichiometric ratio (metal:ligand) of the complex. Antioxidant study of the quercetin and its metal complex against 2, 2-di-phenyl-1-picryl hydrazyl radical showed that the complex has much more radical scavenging activity than free quercetin. The interaction of quercetin-iron (II) complex with DNA was determined using ultraviolet visible spectra, fluorescence spectra and agarose gel electrophoresis. The results showed that quercetin-iron (II) complex can intercalate moderately with DNA, quench a strong intercalator ethidium bromide and compete for the intercalative binding sites. The complex showed significant cleavage of pBR 322 DNA from supercoiled form to nicked circular form and these cleavage effects were dose-dependent. Moreover, the mechanism of DNA cleavage indicated that it was an oxidative cleavage pathway. These results revealed the potential nuclease activity of complex to cleave DNA. In addition, antibacterial activity of complex on E.coli and S. aureus was also investigated. The results showed that complex has higher antibacterial activity than ligand.

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The QSAR study of flavonoid-metal complexes scavenging OH free radical

Cited by 6 publications

References 15 publications

Comparison Between Hesperidin, Coumarin, and Deferoxamine Iron Chelation and Antioxidant Activity Against Excessive Iron in the Iron Overloaded Mice

Comparison Between Hesperidin, Coumarin, and Deferoxamine Iron Chelation and Antioxidant Activity Against Excessive Iron in the Iron Overloaded Mice

Ga(III) complex with morin for kidney cancer cell labelling

Quercetin-Iron Complex: Synthesis, Characterization, Antioxidant, DNA Binding, DNA Cleavage, and Antibacterial Activity Studies

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