The QcrB Inhibitors TB47 and Telacebec Do Not Potentiate the Activity of Clofazimine in Mycobacterium abscessus

Abstract

The anti-tuberculosis drug telacebec is ineffective against Mycobacterium abscessus . A recent study suggested that TB47, a telacebec analogue, potentiated the efficacy of clofazimine against M. abscessus . Here, we report that TB47 is not only ineffective against M. abscessus in vitro , it also does not potentiate the activity of clofazimine.