In this paper, we use the generalized q-polynomials with double q-binomial coefficients and homogeneous q-operators [J. Difference Equ. Appl. 20 (2014), 837-851.] to construct q-difference equations with seven variables, which generalize recent works of Jia et al [Symmetry 2021[Symmetry , 13, 1222. In addition, we derive Rogers formulas, extended Rogers formulas and Srivastava-Agarwal type bilinear generating functions for generalized qpolynomials, which generalize generating functions for Cigler's polynomials [J. Difference Equ. Appl. 24 (2018), 479-502.]. Finally, we also derive mixed generating functions using q-difference equations.