The pyriproxyfen metabolite, 4′–OH–PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection.

Vancamp, Pieter; Špirhanzlová, Petra; Sébillot, Anthony; Butruille, Lucile; Mevel, Sébastien Le; Leemans, Michelle; Wejaphikul, Karn; Meima, Marcel E; Mughal, Bilal Babar; Roques, Pierre; Remaud, Sylvie; Fini, Jean-Baptiste; Demeneix, Barbara

doi:10.1016/j.envpol.2021.117654

Cited by 8 publications

(4 citation statements)

References 60 publications

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“…Endocrine disruptors or their functional groups have similar chemical structures to endogenous hormones, with diphenyl ether structure pesticides having potential thyroid hormonedisrupting effects. 73 Pyrethroid insecticides could interfere with the activity of THRs; 74 pyriproxyfen and its metabolite 4′-OHpyriproxyfen could antagonize thyroid hormone action; 75 and difenoconazole induced thyroid endocrine disruption in zebrafish. 76 The similar diphenyl ether structure between famoxadone and thyroid hormones is an important cause of thyroid dysfunction; more attention should be paid to the risk of NAFLD of pesticides containing diphenyl ether structure.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Dysfunction Induced by Fungicide Famoxadone Exposure Contributes to Nonalcoholic Fatty Liver Disease in Male Mice: In Vivo, In Vitro, and In Silico Studies

Xiao,

Cui,

Chen

et al. 2023

Environ. Sci. Technol.

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Thyroid dysfunction has become a serious public health problem, which is considered a trigger of nonalcoholic fatty liver disease (NAFLD). Pesticide exposure could contribute to thyroid dysfunction and NAFLD, but the relationship between these factors remains unclear. In this study, the effects of subchronic famoxadone exposure on thyroid and liver at no observed adverse effect level (NOEL) related concentrations were investigated using in vivo, in vitro, and in silico models. Famoxadone caused hepatic steatosis, lipid metabolism disorder, and liver oxidative stress and induced NAFLD in male mice. The suppression of hepatic fatty acid β-oxidation was the key factor of NAFLD, which was highly associated with hypothalamic–pituitary–thyroid (HPT) axis hormones disorder. Famoxadone disrupted thyroid hormone biosynthesis by causing thyroid follicle aberrations and abnormal HPT axis-related gene expression. In vitro studies confirmed that famoxadone inhibited the transport of thyroxine (T4) into hepatocytes and the conversion of T4 to triiodothyronine (T3). In silico studies verified that famoxadone interfered with the binding of thyroid hormones to proteins mediating thyroid hormone transport, conversion, and activation. This study comprehensively reported the association between NAFLD and thyroid dysfunction caused by famoxadone, providing new perspectives for the health risk evaluation of pesticides with a similar structure in mammals.

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Section: Discussionmentioning

confidence: 99%

Thyroid Dysfunction Induced by Fungicide Famoxadone Exposure Contributes to Nonalcoholic Fatty Liver Disease in Male Mice: In Vivo, In Vitro, and In Silico Studies

Xiao,

Cui,

Chen

et al. 2023

Environ. Sci. Technol.

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“…Moreover, Notch pathway suppression using the DAPT inhibitor was shown to reduce the number of viral particles after infection [65]. Furthermore, Musashi inhibition and the alteration of the differentiation pathway modify ZIKV infection and the production of viral particles [66]. The link with the precursor-specific protein Musashi was further demonstrated by RNA pull-downs, where this protein directly interacts with the 3 UTR of ZIKV RNA and co-localizes with the replication intermediate (DS RNA), as assessed by confocal and STED super-resolution microscopy [67].…”

Section: Zika Virus In Nscs and Btscsmentioning

confidence: 99%

Two Sides of The Same Coin: Normal and Tumoral Stem Cells, The Relevance of In Vitro Models and Therapeutic Approaches: The Experience with Zika Virus in Nervous System Development and Glioblastoma Treatment

Tinnirello,

Chinnici,

Miceli

et al. 2023

IJMS

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Neural stem cells (NSCs) were described for the first time more than two decades ago for their ability to differentiate into all neural cell lineages. The isolation of NSCs from adults and embryos was carried out by various laboratories and in different species, from mice to humans. Similarly, no more than two decades ago, cancer stem cells were described. Cancer stem cells, previously identified in hematological malignancies, have now been isolated from several solid tumors (breast, brain, and gastrointestinal compartment). Though the origin of these cells is still unknown, there is a wide consensus about their role in tumor onset, propagation and, in particular, resistance to treatments. Normal and neoplastic neural stem cells share common characteristics, and can thus be considered as two sides of the same coin. This is particularly true in the case of the Zika virus (ZIKV), which has been described as an inhibitor of neural development by specifically targeting NSCs. This understanding prompted us and other groups to evaluate ZIKV action in glioblastoma stem cells (GSCs). The results indicate an oncolytic activity of this virus vs. GSCs, opening potentially new possibilities in glioblastoma treatment.

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“…These chemicals are measured ubiquitously in sediments globally and in humans. 93 , 94 The production of these chemicals, which has steadily increased since the 1950s, corresponds to a dramatic increase in the incidence of health outcomes that are impacting women and their families (i.e. obesity, diabetes, fertility problems, cancer, and neurodevelopmental disorders).…”

Section: Climate Change and Toxic Chemicalsmentioning

confidence: 99%

“…These chemicals include phthalates, flame retardant chemicals, and perfluorinated compounds, which are all endocrine‐disrupting chemicals and can increase the risk of adverse health effects. These chemicals are measured ubiquitously in sediments globally and in humans 93,94 . The production of these chemicals, which has steadily increased since the 1950s, corresponds to a dramatic increase in the incidence of health outcomes that are impacting women and their families (i.e.…”

Section: Climate Change and Toxic Chemicalsmentioning

confidence: 99%

Climate change, women’s health, and the role of obstetricians and gynecologists in leadership

Giudice

Llamas-Clark

DeNicola³

et al. 2021

Intl J Gynecology & Obste

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Climate change is one of the major global health threats to the world's population. It is brought on by global warming due in large part to increasing levels of greenhouse gases resulting from human activity, including burning fossil fuels (carbon dioxide), animal husbandry (methane from manure), industry emissions (ozone, nitrogen oxides, sulfur dioxide), vehicle/factory exhaust, and chlorofluorocarbon aerosols that trap extra heat in the earth's atmosphere. Resulting extremes of weather give rise to wildfires, air pollution, changes in ecology, and floods. These in turn result in displacement of populations, family disruption, violence, and major impacts on water quality and availability, food security, public health and economic infrastructures, and limited abilities for civil society to maintain citizen safety. Climate change also has direct impacts on human health and well-being. Particularly vulnerable populations are affected, including women, pregnant women, children, the disabled, and the elderly, who comprise the majority of the poor globally. Additionally, the effects of climate

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The pyriproxyfen metabolite, 4′–OH–PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection.

Cited by 8 publications

References 60 publications

Thyroid Dysfunction Induced by Fungicide Famoxadone Exposure Contributes to Nonalcoholic Fatty Liver Disease in Male Mice: In Vivo, In Vitro, and In Silico Studies

Thyroid Dysfunction Induced by Fungicide Famoxadone Exposure Contributes to Nonalcoholic Fatty Liver Disease in Male Mice: In Vivo, In Vitro, and In Silico Studies

Two Sides of The Same Coin: Normal and Tumoral Stem Cells, The Relevance of In Vitro Models and Therapeutic Approaches: The Experience with Zika Virus in Nervous System Development and Glioblastoma Treatment

Climate change, women’s health, and the role of obstetricians and gynecologists in leadership

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