2005
DOI: 10.1001/archderm.141.2.242
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The Pyrin Family of Fever Genes

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Cited by 30 publications
(2 citation statements)
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References 60 publications
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“…[2][3][4][7][8][9] FMF is the result of a mutation in the gene MEFV which codes for pyrin, a protein that helps regulate molecular signaling pathways involved in inflammation, cytokine and chemokine processing, and apoptosis. 10 To our knowledge, the pyrin genes of Shar Pei dogs have not been investigated.…”
Section: Discussionmentioning
confidence: 99%
“…[2][3][4][7][8][9] FMF is the result of a mutation in the gene MEFV which codes for pyrin, a protein that helps regulate molecular signaling pathways involved in inflammation, cytokine and chemokine processing, and apoptosis. 10 To our knowledge, the pyrin genes of Shar Pei dogs have not been investigated.…”
Section: Discussionmentioning
confidence: 99%
“…The NLR (nucleotide binding domain and leucine rich, or NOD-like receptor, where NOD is an abbreviation for nucleotide oligomerization domain) family of genes also contain the PYD domain [27], [28], [29], [30]. While the pyrin protein is thought to function in apoptotic and inflammatory signaling pathways [31], [32], its exact function has been debated. In a better-studied system, cryopyrin or NLRP3, which also has the PYD domain, is activated to assemble the inflammasome [33], a multi-protein structure that ultimately results in activation of pro-caspase-1 that, in turn, processes pro-IL-1β to IL-1β.…”
Section: Introductionmentioning
confidence: 99%