The pyrimido-pyrimidine derivatives RA233 and RX-RA85 affect cell cycle distribution of two murine tumour cell lines

Lichtner, Rosemarie B.; Hutchinson, Gillian; Hellmann, K.

doi:10.1016/0277-5379(89)90152-1

Cited by 9 publications

(5 citation statements)

References 18 publications

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“…126 Several other platelet aggregation inhibitors (ditazole, bencyclan, cyproheptadine, dipyridamole, pentoxifylline) showed no significant influence on metastases formation in animal tumor models. 125,[127][128][129][130][131][132] Interestingly, similar to trapidil, ticlopidine, diltiazem, and dipyridamole significantly reduced spontaneous pulmonary metastases in mice only when these agents were given after removal of the primary tumor. 126 Mopidamole was demonstrated to inhibit significantly spontaneous lung metastasis in syngeneic Wilms' tumor of the rat, the C1300-neuroblastoma of the mouse, the HM-Kim mammary carcinoma of the rat, and Lewis lung carcinoma of the mouse.…”

Section: Platelets As a Target In Anticancer Strategiesmentioning

confidence: 95%

Inhibition of Platelet Function: Does It Offer a Chance of Better Cancer Progression Control?

Sierko

Wojtukiewicz

2007

Semin Thromb Hemost

107

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Thrombocytosis is frequently (10 to 57%) observed in cancer patients. Although the mechanisms underlying thrombocytosis are not yet fully elucidated, tumor-derived factors with thrombopoietin-like activity, growth factors, platelet-derived microparticles, and factors released from bone marrow endothelial cells as well as growth factors secreted by megakaryocytes (acting via an autocrine loop) are claimed to influence this process. The course of cancer is strongly associated with hypercoagulable state, which results from direct influences of tumor cells themselves and various indirect mechanisms. Activated platelets provide procoagulant surface amplifying the coagulation process. It is well documented that proteins of the hemostatic system influence different steps of metastasis, angiogenesis, and proteolytic events. Much less is known about the role of platelets in tumor growth and their possible contribution to prevention of tumor cells from the host immune system. Multidirectional activities of platelets during tumor development and metastatic dissemination create a possibility of introducing antiplatelet agents in anticancer therapy. The spectrum of plausible therapies includes antibodies against glycoprotein IIb-IIIa, direct thrombin inhibitors, protease activated receptor-1 targeted therapy, as well as cyclooxygenase (COX) and lipoxygenase (LOX) inhibitors. However, there is no sufficient information on a specific type of cancer where progression does depend on platelet function. Despite numerous experimental studies conducted, to date none of the new specific antiplatelet agents were tested in clinical trials in a cancer patient population.

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Section: Platelets As a Target In Anticancer Strategiesmentioning

confidence: 95%

Inhibition of Platelet Function: Does It Offer a Chance of Better Cancer Progression Control?

Sierko

Wojtukiewicz

2007

Semin Thromb Hemost

107

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“…Pyrano [2,3-d]pyrimidinones (A) and pyrido [2,3-d]pyrimidines (B) (Fig. 1) are two classes of nitrogen-containing heterocyclic compounds that show considerable pharmaceutical and biological activities, including anticancer, antitumor, antima-larial, antibacterial, antihypertensive, anti-inflammatory, hepatoprotective, cardiotonic, vasodilator, bronchiodilator, antifolate, and antiallergic activities [5][6][7][8][9][10][11][12][13][14][15][16][17]. They are also used in the preparation of dyes and pigments [18] and flavoring agents [19], and in luminescence chemistry [20].…”

Section: Introductionmentioning

confidence: 99%

Efficient synthesis of pyrano[2,3- d ]pyrimidinone and pyrido[2,3- d ]pyrimidine derivatives in presence of novel basic ionic liquid catalyst

Jolodar

Shirini

Seddighi

2017

Chinese Journal of Catalysis

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“…In addition, pyrimido[4,5‐d]pyrimidinone derivatives were simply synthetized via the reaction of barbituric acid, aldehydes and urea or thiourea under the presence of unripe grape juices. These derivatives are responsible for biological and pharmacological activities such as anti‐inflammatory, antioxidant, antimicrobial, antitumor, and antiviral properties 30,77–79 …”

Section: Potential Opportunities Of Thinned Grapes Due To Their Bioactive Componentsmentioning

confidence: 99%

Potential opportunities of thinned clusters in viticulture: a mini review

et al. 2021

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Crop thinning is a common practice performed in the vineyard consisting of whole clusters or individual fruits being removed after flowering is attained. Current studies have reported that unripe grape products as verjuice and sour grape sauce contain high content of bioactive compounds such as polyphenols, sugars, organic acids, nitrogenous compounds and sterols. This mini‐review overviewed the bioactive components obtained from thinned unripe grapes such as phenolic compounds, sugars, organic acids, minerals, nitrogen compounds and sterols, and their use as antibrowning and whitening agents, natural catalysts, food preservative and food additive. In addition, their beneficial effects for human health also were reviewed, as well as the practices to maximize the extraction of antioxidant compounds. Therefore, revalorizing the waste from this management practice in viticulture can increase the vineyard sustainability and farmers' economic profits. © 2021 Society of Chemical Industry

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The pyrimido-pyrimidine derivatives RA233 and RX-RA85 affect cell cycle distribution of two murine tumour cell lines

Cited by 9 publications

References 18 publications

Inhibition of Platelet Function: Does It Offer a Chance of Better Cancer Progression Control?

Inhibition of Platelet Function: Does It Offer a Chance of Better Cancer Progression Control?

Efficient synthesis of pyrano[2,3- d ]pyrimidinone and pyrido[2,3- d ]pyrimidine derivatives in presence of novel basic ionic liquid catalyst

Potential opportunities of thinned clusters in viticulture: a mini review

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