The pyrimido-pyrimidine derivatives RA233 and RX-RA85 affect cell cycle distribution of two murine tumour cell lines

Inhibition of Platelet Function: Does It Offer a Chance of Better Cancer Progression Control?

“…126 Several other platelet aggregation inhibitors (ditazole, bencyclan, cyproheptadine, dipyridamole, pentoxifylline) showed no significant influence on metastases formation in animal tumor models. 125,[127][128][129][130][131][132] Interestingly, similar to trapidil, ticlopidine, diltiazem, and dipyridamole significantly reduced spontaneous pulmonary metastases in mice only when these agents were given after removal of the primary tumor. 126 Mopidamole was demonstrated to inhibit significantly spontaneous lung metastasis in syngeneic Wilms' tumor of the rat, the C1300-neuroblastoma of the mouse, the HM-Kim mammary carcinoma of the rat, and Lewis lung carcinoma of the mouse.…”

Inhibition of Platelet Function: Does It Offer a Chance of Better Cancer Progression Control?

“…126 Several other platelet aggregation inhibitors (ditazole, bencyclan, cyproheptadine, dipyridamole, pentoxifylline) showed no significant influence on metastases formation in animal tumor models. 125,[127][128][129][130][131][132] Interestingly, similar to trapidil, ticlopidine, diltiazem, and dipyridamole significantly reduced spontaneous pulmonary metastases in mice only when these agents were given after removal of the primary tumor. 126 Mopidamole was demonstrated to inhibit significantly spontaneous lung metastasis in syngeneic Wilms' tumor of the rat, the C1300-neuroblastoma of the mouse, the HM-Kim mammary carcinoma of the rat, and Lewis lung carcinoma of the mouse.…”

Potential opportunities of thinned clusters in viticulture: a mini review

“…In addition, pyrimido[4,5‐d]pyrimidinone derivatives were simply synthetized via the reaction of barbituric acid, aldehydes and urea or thiourea under the presence of unripe grape juices. These derivatives are responsible for biological and pharmacological activities such as anti‐inflammatory, antioxidant, antimicrobial, antitumor, and antiviral properties 30,77–79 …”

Theoretical Study of the Effect of the Solvent on the Electronic Properties of Pyrimidopyrimidine Derivatives

“…Because of their importance and their widespread presence in living organisms, substances based on pyrimidopyrimidines or tetra-azanaphthalenes − organic heterobicyclic compounds with a skeleton consisting of two pyrimidine rings that are ortho-fused to each other at any position − have aroused the interest of researchers in organic and pharmacology chemistry for several decades [1][2][3][4][5][6][7][8][9][10][11][12]. These molecules are well known for their important biological, biochemical and therapeutic properties as well as their rich and varied chemistry [10][11][12][13][14][15][16][17][18][19][20][21][22][23].…”

Inhibition of Platelet Function: Does It Offer a Chance of Better Cancer Progression Control?

“…126 Several other platelet aggregation inhibitors (ditazole, bencyclan, cyproheptadine, dipyridamole, pentoxifylline) showed no significant influence on metastases formation in animal tumor models. 125,[127][128][129][130][131][132] Interestingly, similar to trapidil, ticlopidine, diltiazem, and dipyridamole significantly reduced spontaneous pulmonary metastases in mice only when these agents were given after removal of the primary tumor. 126 Mopidamole was demonstrated to inhibit significantly spontaneous lung metastasis in syngeneic Wilms' tumor of the rat, the C1300-neuroblastoma of the mouse, the HM-Kim mammary carcinoma of the rat, and Lewis lung carcinoma of the mouse.…”

Potential opportunities of thinned clusters in viticulture: a mini review

“…In addition, pyrimido[4,5‐d]pyrimidinone derivatives were simply synthetized via the reaction of barbituric acid, aldehydes and urea or thiourea under the presence of unripe grape juices. These derivatives are responsible for biological and pharmacological activities such as anti‐inflammatory, antioxidant, antimicrobial, antitumor, and antiviral properties 30,77–79 …”

Theoretical Study of the Effect of the Solvent on the Electronic Properties of Pyrimidopyrimidine Derivatives

“…Because of their importance and their widespread presence in living organisms, substances based on pyrimidopyrimidines or tetra-azanaphthalenes − organic heterobicyclic compounds with a skeleton consisting of two pyrimidine rings that are ortho-fused to each other at any position − have aroused the interest of researchers in organic and pharmacology chemistry for several decades [1][2][3][4][5][6][7][8][9][10][11][12]. These molecules are well known for their important biological, biochemical and therapeutic properties as well as their rich and varied chemistry [10][11][12][13][14][15][16][17][18][19][20][21][22][23].…”

Inhibition of Platelet Function: Does It Offer a Chance of Better Cancer Progression Control?

“…126 Several other platelet aggregation inhibitors (ditazole, bencyclan, cyproheptadine, dipyridamole, pentoxifylline) showed no significant influence on metastases formation in animal tumor models. 125,[127][128][129][130][131][132] Interestingly, similar to trapidil, ticlopidine, diltiazem, and dipyridamole significantly reduced spontaneous pulmonary metastases in mice only when these agents were given after removal of the primary tumor. 126 Mopidamole was demonstrated to inhibit significantly spontaneous lung metastasis in syngeneic Wilms' tumor of the rat, the C1300-neuroblastoma of the mouse, the HM-Kim mammary carcinoma of the rat, and Lewis lung carcinoma of the mouse.…”

Potential opportunities of thinned clusters in viticulture: a mini review

“…In addition, pyrimido[4,5‐d]pyrimidinone derivatives were simply synthetized via the reaction of barbituric acid, aldehydes and urea or thiourea under the presence of unripe grape juices. These derivatives are responsible for biological and pharmacological activities such as anti‐inflammatory, antioxidant, antimicrobial, antitumor, and antiviral properties 30,77–79 …”

Theoretical Study of the Effect of the Solvent on the Electronic Properties of Pyrimidopyrimidine Derivatives

“…Because of their importance and their widespread presence in living organisms, substances based on pyrimidopyrimidines or tetra-azanaphthalenes − organic heterobicyclic compounds with a skeleton consisting of two pyrimidine rings that are ortho-fused to each other at any position − have aroused the interest of researchers in organic and pharmacology chemistry for several decades [1][2][3][4][5][6][7][8][9][10][11][12]. These molecules are well known for their important biological, biochemical and therapeutic properties as well as their rich and varied chemistry [10][11][12][13][14][15][16][17][18][19][20][21][22][23].…”