The Pyloric Sphincteric Cylinder in Health and Disease

Keet, Albertus D.

doi:10.1007/978-3-642-77708-0

Cited by 16 publications

(8 citation statements)

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“…The shape of the model was created using a series of 89 auxiliary circles that extended between the lesser and greater curvatures of a crossectional image of the human stomach (MedlinePlus). The model was then scaled to reproduce the average dimensions of a human stomach (Geliebter et al, 1992;Keet, 1993;Schulze, 2006).…”

Section: Methodsmentioning

confidence: 99%

On the kinematics and efficiency of advective mixing during gastric digestion – A numerical analysis

Ferrua¹,

Xue²,

Singh³

2014

Journal of Biomechanics

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Section: Methodsmentioning

confidence: 99%

On the kinematics and efficiency of advective mixing during gastric digestion – A numerical analysis

Ferrua¹,

Xue²,

Singh³

2014

Journal of Biomechanics

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“…The normal capacity of the human stomach varies from 0.25 to about 1.7 L (Einhorn 2009), and its geometry not only changes from one individual to another, but it is also significantly influenced by the position of the body, the condition of surrounding viscera and organs, the amount and type of meal ingested, and the digestion time (Liao and others 2004;Schulze 2006). After a typical meal, an average-sized human stomach is about 10 cm wide at its widest point, its greater curvature is about 30 cm long, has a pyloric ring diameter of 1.1 cm or less, and its average capacity is about 0.94 L (Keet 1993;Schulze 2006). Gastric motility during digestion ("postprandial" period).…”

Section: Stomach Geometry and Motility During Digestionmentioning

confidence: 99%

Modeling the Fluid Dynamics in a Human Stomach to Gain Insight of Food Digestion

Ferrua¹,

Singh²

2010

Journal of Food Science

250

152

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During gastric digestion, food is disintegrated by a complex interaction of chemical and mechanical effects. Although the mechanisms of chemical digestion are usually characterized by using in vitro analysis, the difficulty in reproducing the stomach geometry and motility has prevented a good understanding of the local fluid dynamics of gastric contents. The goal of this study was to use computational fluid dynamics (CFD) to develop a 3-D model of the shape and motility pattern of the stomach wall during digestion, and use it to characterize the fluid dynamics of gastric contents of different viscosities. A geometrical model of an averaged-sized human stomach was created, and its motility was characterized by a series of antral-contraction waves of up to 80% relative occlusion. The flow field within the model (predicted using the software Fluent™) strongly depended on the viscosity of gastric contents. By increasing the viscosity, the formation of the 2 flow patterns commonly regarded as the main mechanisms driving digestion (i.e., the retropulsive jet-like motion and eddy structures) was significantly diminished, while a significant increase of the pressure field was predicted. These results were in good agreement with experimental data previously reported in the literature, and suggest that, contrary to the traditional idea of a rapid and complete homogenization of the meal, gastric contents associated with high viscous meals are poorly mixed. This study illustrates the capability of CFD to provide a unique insight into the fluid dynamics of the gastric contents, and points out its potential to develop a fundamental understanding and modeling of the mechanisms involved in the digestion process.Practical ApplicationThis study illustrates the capability of computational fluid dynamic techniques to provide a unique insight into the dynamics of the gastric contents, pointing out its potential to develop a fundamental understanding and modeling of the human digestion process.

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“…The main extrinsic sympathetic nerve supply to the pylorus is provided by the celiac plexus via fibers accompanying the left gastric, hepatic and splenic arteries (Keet, 1993), however, the precise localization of the extrinsic sympathetic perikarya still remains unclear. According to some authors, pyloric sympathetic nerve fibers additionally originate from some of the paravertebral ganglia, such as cranial cervical ganglion as well as cervicothoracic ganglion (Elfvin and Lindh, 1982).…”

Section: Introductionmentioning

confidence: 99%

Localization and neurochemical characteristics of the extrinsic sympathetic neurons projecting to the pylorus in the domestic pig

Załęcki

2012

Journal of Chemical Neuroanatomy

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The Pyloric Sphincteric Cylinder in Health and Disease

Abstract: Library of Congress Cataloging-in-Publication Data Keet, A. D. (Albertus D.) The pyloric sphincteric cylinder in health and diseasel A. D. Keet. p.cm. Includes bibliographical references and index.

Cited by 16 publications

References 0 publications

On the kinematics and efficiency of advective mixing during gastric digestion – A numerical analysis

On the kinematics and efficiency of advective mixing during gastric digestion – A numerical analysis

Modeling the Fluid Dynamics in a Human Stomach to Gain Insight of Food Digestion

Localization and neurochemical characteristics of the extrinsic sympathetic neurons projecting to the pylorus in the domestic pig

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