Abstract:Many component processes of reward require appropriate serotonin (5HT) and dopamine (DA) neurotransmission within key limbic brain regions. Evidence suggests that dysregulation of 5HT and DA transmission can precipitate reward dysfunction and major depressive disorder (MDD) symptoms in genetically predisposed individuals. Various neurobiological indicators (biomarkers) of MDD have been proposed, including changes in signal transduction pathways, protein phosphorylation, and gene expression in subcortical, rewa… Show more
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