The Purity of Chloroform B.P

Abstract

The “chloro‐compound”, isolated during previous work on a source of error in the assay of strychnine salts and preparations1, has been identified as strychnine chloromethobromide. Its identity has been established by the preparation of authentic strychnine chloromethobromide and the corresponding nitrate and iodide. Chlorobromomethane occurs in chloroform B.P. used for extraction of strychnine during the assay. The presence of this impurity in chloroform has been confirmed by gas chromatography which also revealed the presence of methylene dichloride as an additional impurity.

Allosteric Interactions of Quaternary Strychnine and Brucine Derivatives with Muscarinic Acetylcholine Receptors

“…Strychnine N -oxide 11 was prepared from the reaction of strychnine and hydrogen peroxide . N-Amination of brucine and strychnine to give 12 and 22 , respectively, was achieved with o -mesitylenesulphonylhydroxylamine, following a literature procedure described for N-amination of tertiary amines. , N -Chloromethyl brucine 20 was prepared following a procedure similar to that reported for N -chloromethyl strychnine 1 Quaternization Reactions of Strychnine and Brucine …”

A specific method for the determination of amphetamine in urine

“…Amphetamine hydrochloride is much more soluble in chloroform than ammonium chloride and, therefore, chloroform extraction was used to separate the two. The chloroform was specially purified because of the known interaction of impurities in commercial chloroform with many bases (Caws & Foster, 1957). Ethanol was added to purified chloroform to prevent formation of carbonyl chloride because of the latter's reaction with amphetamine and consequent interference with the assay procedure.…”

Reaction of ephedrine with chloroform

“…This arises from the impurity, bromochloromethane, which together with dichloromethane is present in chloroform B.P. (Caws & Foster, 1957). When (-)-ephedrine is refluxed with pure bromochloromethane a mixture of the hydrobromide and hydrochloride salts of the alkaloid is formed in equimolecular proportions.…”