The pulsed ultrasound strategy effectively decreases the S. aureus population of chronic rhinosinusitis patients

Feizabadi, Narjes; Sarrafzadeh, Javad; Fathali, Mojtaba; Vasaghi‐Gharamaleki, Behnoosh; Dadgoo, Mahdi; Kardan-Yamchi, Jalil; Kazemian, Hossein; Hesam-Shariati, Sonia; Feizabadi, Mohammad Mehdi

doi:10.1186/s13104-019-4579-3

Cited by 7 publications

(9 citation statements)

References 20 publications

(27 reference statements)

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“…In many studies were enrolled patients whose previous treatments (medical treatment or surgery) had not been effective in relieving symptoms. 5,15,16,19,20 The studies had assumed pretest-posttest design 5,15,17 and single- 15,17,20,21 or double-blinded 19,22 randomized…”

Section: Resultsmentioning

confidence: 99%

“…Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies controlled trial. The modalities of therapeutic ultrasound investigated were pulsed 15,16,19,20,22,24 and continuous, 17,[21][22][23] and the studies evaluated the ultrasound effects immediately after one session (shortterm effects) 18 or after a few sessions (long-term effects) 5,[15][16][17]19,21,22,25 of treatment. The main outcomes evaluated, and the results of the studies included in this review are summarized in Table 3.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the patient's scores from the SNOT-20 questionnaire were less after treatment compared to the initial stage (45.2 AE 18.8 vs. 9.8 AE 9.31, respectively). 22 Pulsed ultrasound was also applied in a single blinded randomized controlled study, which included 21 participants in each group (US and control) treated after endoscopic sinus surgery for extraction of nasal polyps. The patients underwent to six sessions of treatment, during 3 weeks, and the symptoms were evaluated according the SNOT-22.…”

Section: Pulsed Ultrasoundmentioning

confidence: 99%

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Therapeutic ultrasound as a treatment for chronic rhinosinusitis: A systematic review

Silva

Isoppo

2021

Clinical Respiratory J

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Objective: To investigate the effects of therapeutic ultrasound in symptoms of patients with chronic rhinosinusitis. Data source and study selection: Searches were carried out in the MEDLINE (via OVID), SCOPUS, PubMed and Virtual Health Library databases. The study selection is as follows: Pre-experimental and experimental studies in English, Spanish and Portuguese that evaluated the effects of ultrasound on the signs and symptoms of patients with chronic rhinosinusitis were included. After study selection, data extraction, risk of bias and quality assessment, we performed a qualitative description of current data. Results: Nine studies were selected, providing 309 participants (20 to 47 volunteers in each study), with an average age of 44.5 years. Three studies had assumed pretest-posttest design, four studies were single-blinded randomized controlled trial and the two studies were double-blinded randomized controlled trial. The modalities of ultrasound investigated were pulsed and continuous, and the studies evaluated the ultrasound effects immediately after one session or after a few sessions of treatment (6, 10 or 15 sessions). The use of ultrasound, in both continuous and pulsed modalities, demonstrated to reduce characteristic signs and symptoms of chronic rhinosinusitis. Despite these results, only two studies had a low risk of bias. A meta-analysis was not possible due to the huge heterogeneity of included studies.Conclusions: Despite ultrasound in continuous and pulsed modalities showing similar positive effects in the treatment of chronic rhinosinusitis, the studies are small, short duration, poor design and with a high risk of bias. Thereby, ultrasound cannot be appointed as a potential adjunct resource to current methods of treating chronic rhinosinusitis until large randomised controlled studies are performed.K E Y W O R D S physical therapy modalities, respiratory tract infections, sinusitis, ultrasonics Chronic rhinosinusitis is a clinical syndrome characterized by persistent inflammation of the mucous membranes of the nasal cavity and paranasal sinuses, with an estimated prevalence of 10% in Western populations. 1,2 The syndrome is defined by the presence of two or more symptoms, namely, nasal obstruction,

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Pulsed Ultrasoundmentioning

confidence: 99%

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Therapeutic ultrasound as a treatment for chronic rhinosinusitis: A systematic review

Silva

Isoppo

2021

Clinical Respiratory J

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“…We hypothesize that the application of new methods of biofilm destruction may reduce the extent and chronicity of the disease. Amongst the promising methods that could be implemented in AD are, for example, the pulse ultrasound [27, 28] and the application of antimicrobial peptides [29, 30] to the anterior nares as long-time prevention of S. aureus dispersal.…”

Section: Discussionmentioning

confidence: 99%

The Propensity to Form Biofilm in vitro by Staphylococcus aureus Strains Isolated from the Anterior Nares of Patients with Atopic Dermatitis: Clinical Associations

et al. 2020

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Background: Atopic dermatitis is a chronic inflammatory dermatosis with complex pathogenesis. The skin microbiome in atopic dermatitis is dominated by Staphylococcus aureus which shows the ability to produce biofilm. Objectives: The aim of this work was to assess the influence of S. aureus biofilm on the course of atopic dermatitis. Methods: Disease severity was evaluated based on the SCORAD index in 56 adult patients with atopic dermatitis. Microtiter plate assay of the propensity to form biofilm was performed on S. aureus strains isolated from the anterior nares, lesional skin, and nonlesional skin. Microbiological results were correlated to the clinical parameters and total IgE concentration. Results: Biofilm-producing strains of S. aureus were identified in 76.3% (29/38) and 79.1% (34/43) of samples from the anterior nares and lesional skin, respectively (p > 0.05), and in 48.5% (16/33) of samples from nonlesional skin (p < 0.03). Patients colonized by biofilm-producing strains of S. aureus within the anterior nares showed statistically higher mean values of total and objective SCORAD and its components (extent, dryness), and of the largest extent of skin lesions during the flares in the last year when compared to patients colonized by non-biofilm-producing strains. Carriage of biofilm-producing S. aureus on lesional skin was associated with higher mean values of the extent of skin lesions during stable periods of the disease. Conclusions: The results of this study may suggest a relationship between the production of biofilm by S. aureus strains colonizing the anterior nares and the course of atopic dermatitis. Biofilm seems crucial for dispersal and persistent colonization of large areas of the skin by this pathogen. Destruction of S. aureus biofilm could positively affect the course of atopic dermatitis.

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“…Consistently, Hauck et al reported both continuous or pulsed ultrasound could improve endothelial function in a randomized clinical trial of 30 patients (109).It appears that LIPUS is also efficient at treating bacterial infection. For example, Feizabadi et al reported that LIPUS decreased the population of Staphylococcus aureus in chronic rhinosinusitis patients(110). Karosi et al exposed nasal polyps removed from a patient with chronic rhinosinusitis to low-intensity continuous ultrasound(114) and found…”

mentioning

confidence: 99%

Review on experimental study and clinical application of low- intensity pulsed ultrasound in inflammation

Xu¹,

Wang²,

Wu³

et al. 2021

Quant Imaging Med Surg

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Low-intensity pulsed ultrasound (LIPUS), as physical therapy, is widely used in both research and clinical settings. It induces multiple bioeffects, such as alleviating pain, promoting tissue repair, and shortening disease duration. LIPUS can also mediate inflammation. This paper reviews the application of LIPUS in inflammation and discusses the underlying mechanism. In basic experiments, LIPUS can regulate inflammatory responses at the cellular level by affecting some signaling pathways. In a clinical trial, LIPUS has been shown to alleviate inflammatory responses efficiently. As a cheap, safe, and convenient physical method, LIPUS is promising as anti-inflammatory therapy.

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The pulsed ultrasound strategy effectively decreases the S. aureus population of chronic rhinosinusitis patients

Cited by 7 publications

References 20 publications

Therapeutic ultrasound as a treatment for chronic rhinosinusitis: A systematic review

Therapeutic ultrasound as a treatment for chronic rhinosinusitis: A systematic review

The Propensity to Form Biofilm in vitro by <b><i>Staphylococcus aureus</i></b> Strains Isolated from the Anterior Nares of Patients with Atopic Dermatitis: Clinical Associations

Review on experimental study and clinical application of low- intensity pulsed ultrasound in inflammation

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