The Pulp Healing Process: From Generation to Regeneration*

Assessment of Mineral Trioxide Aggregate pulpotomy in mature permanent teeth with carious exposures

“…The pulp environment and inflammation are critical to the signalling events associated with the induction of cell differentiation and subsequent regulatory control of the secretory activity of these cells (Schmalz & Smith 2014). After loss of the primary odontoblasts in response to severe noxious irritation, the main evidence-based observation in the literature supports that reparative dentine is formed by specific cells undergoing cyto-differentiation (odontoblast-like cells) (Smith & Lesot 2001, Goldberg & Smith 2004, Simon et al 2012. A recent study found that pulpal fibroblasts or fibroblast-like cells produced a calcific material that resembles pulp stones rather than tubular dentine under CH as a direct pulp capping procedure; this hard tissue barrier was considered to represent a repair response rather than a regenerative process (Ricucci et al 2014b).…”

A prehistoric flexed human burial from Pha Phen, Middle Mekong Valley, Laos: its context in Southeast Asia

“…Despite this, there is no visible exposure of the pulp cavities. This suggests the wear occurred slowly enough for secondary, or possibly tertiary, dentine to maintain the integrity of the occlusal surface (Simon et al, 2013). The wear on both maxillary and mandibular left canines and lateral inci- sors is angled lingually, although the wear on the maxillary left central incisor is flat.…”