The pulmonary deposition and retention of indium-111 labeled ultrafine carbon particles in healthy individuals

Klepczyńska-Nyström, Anna; Sánchez-Crespo, Alejandro; Andersson, Martin; Falk, Rolf; Lundin, Anders; Larsson, Britt‐Marie; Svartengren, Magnus

doi:10.3109/08958378.2012.708065

Cited by 8 publications

(4 citation statements)

References 34 publications

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“…Regarding this calculation, if PM2.5 is inhaled for 208 days at the maximum value within the environmental standards in Japan, the exposure exceeds the no-observed-adverse-effect level estimated in this study. However, considering that PM2.5 is slowly eliminated from the lung or brain [ 8 , 45 ], long-term exposure over years may be of concern. On the other hand, although air pollution has regional and seasonal characteristics, there are many areas where PM2.5 in the atmosphere is relatively high throughout the year; India’s average PM2.5 concentration level was 75 to over 85 μg/m 3 in 2019 [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation

et al. 2023

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Background A recent epidemiological study showed that air pollution is closely involved in the prognosis of ischemic stroke. We and others have reported that microglial activation in ischemic stroke plays an important role in neuronal damage. In this study, we investigated the effects of urban aerosol exposure on neuroinflammation and the prognosis of ischemic stroke using a mouse photothrombotic model. Results When mice were intranasally exposed to CRM28, urban aerosols collected in Beijing, China, for 7 days, microglial activation was observed in the olfactory bulb and cerebral cortex. Mice exposed to CRM28 showed increased microglial activity and exacerbation of movement disorder after ischemic stroke induction. Administration of core particles stripped of attached chemicals from CRM28 by washing showed less microglial activation and suppression of movement disorder compared with CRM28-treated groups. CRM28 exposure did not affect the prognosis of ischemic stroke in null mice for aryl hydrocarbon receptor, a polycyclic aromatic hydrocarbon (PAH) receptor. Exposure to PM2.5 collected at Yokohama, Japan also exacerbated movement disorder after ischemic stroke. Conclusion Particle matter in the air is involved in neuroinflammation and aggravation of the prognosis of ischemic stroke; furthermore, PAHs in the particle matter could be responsible for the prognosis exacerbation.

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Section: Discussionmentioning

confidence: 99%

Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation

et al. 2023

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“…Klepczynska-Nystrom et al 18 reported that about 95% of ultrafine carbon particles were retained in the lung 7 days after exposure. If toner particles are harmful to human lung, the higher the exposure concentrations are, the severer the effects may be on chest x-rays.…”

Section: Chest X-ray Examinationsmentioning

confidence: 98%

“…Concerning the chest x-ray examinations, a total of seven subjects had chest x-rays classified into category 1/0 according to the ILO international classification of pneumoconiosis radiographs through the follow-up period: three subjects in the low exposure group and one subject in the control group in the first survey, one subject in the low exposure group and one subject in the control group in the second survey, and one subject in the low exposure group in the fifth survey. Klepczynska-Nystrom et al 18 reported that about 95% of ultrafine carbon particles were retained in the lung 7 days after exposure. If toner particles are harmful to human lung, the higher the exposure concentrations are, the severer the effects may be on chest x-rays.…”

Section: Chest X-ray Examinationsmentioning

confidence: 99%

“…An association between PM and respiratory effect in healthy subjects has not been clearly established in epidemiological studies. Recently, some studies such as ''a study on pulmonary deposition and retention of ultrafine carbon particles 18 and a study on acute change in respiratory function'' were carried out. 19 However, these reports were cross-sectional studies and lacked sufficient objective measures to evaluate the health impact of toner on humans; hence, a well-designed epidemiological study was needed.…”

Section: Introductionmentioning

confidence: 99%

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A cohort study using pulmonary function tests and x-ray examination in toner-handling workers

et al. 2014

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Objectives: This study uses pulmonary function tests and chest x-ray examinations to examine the relationship between toner-handling work and its health effects. Methods: The subjects were 1504 male workers in a Japanese toner and photocopier manufacturing company, in the age range from 19 to 50 years in 2003. Personal exposure measurements, pulmonary function tests, chest x-ray examinations, biomarker measurements, and a questionnaire about respiratory symptoms were conducted. The present study reports the results of pulmonary function tests and chest x-ray examinations conducted in the subjects, which includes a cross-sectional study on the toner handling and non-handling workers and a longitudinal study from 2003 to 2008. Results: Few significant findings were suspected to be caused by toner exposure found in pulmonary function indices in both the cross-sectional and longitudinal studies. Any obvious fibrotic findings in chest x-ray findings related to the toner exposure could not be found out. Conclusion: No evidence of adverse effects on pulmonary function indices and chest x-rays was present in the toner-handling workers as compared to the nonspecifically exposed workers. Although the toner exposure concentration is quite low in the current well-controlled working environment, even among the toner-handling workers, we would like to continue this study in the future to verify the toner exposure health effects.

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The role of IL-6 released from pulmonary epithelial cells in diesel UFP-induced endothelial activation

Bengalli

Longhin

Marchetti

et al. 2017

Environmental Pollution

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The pulmonary deposition and retention of indium-111 labeled ultrafine carbon particles in healthy individuals

Abstract: No evidence for particle translocation from the lungs could be proven 7 days after exposure. It is possible to follow-up Indium-111 labeled UF carbon particles at least 1 month post-administration without increasing the administered activity.

Cited by 8 publications

References 34 publications

Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation

Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation

A cohort study using pulmonary function tests and x-ray examination in toner-handling workers

The role of IL-6 released from pulmonary epithelial cells in diesel UFP-induced endothelial activation

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