The psychosocial burden of hand eczema: Data from a European dermatological multicentre study

Marrón, S.E.; Tómas-Aragonés, Lucía; López, Jorge Navarro; Gieler, Uwe; Kupfer, Jörg; Dalgard, Florence; Lien, Lars; Finlay, Andrew Y.; Poot, F.; Linder, Dennis; Szepietowski, Jacek; Miséry, Laurent; Jemec, Gregor B. E.; Романов, Д. В.; Sampogna, Francesca; Szabó, Csanád; Altunay, İlknur Kıvanç; Koulil, Saskia Spillekom‐van; Balieva, Flora; Ali, Faraz; Halvorsen, Jon Anders; Marijuán, Pedro C.

doi:10.1111/cod.12973

Cited by 33 publications

(52 citation statements)

References 39 publications

(83 reference statements)

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“…Female patients probably had more distress related to limitations in work, leisure time, or domestic activities. Previous studies showed a considerable psychosocial burden of hand eczema and underline that anxiety and depression are more common in female patients . In this study we did not find an association between female sex and impairment of HRQoL in the QOLHEQ subdomain “emotions.” The regression analyses showed that lower “global satisfaction” was associated with more impairment of HRQoL; the standardized beta was −0.44, which indicates a moderate correlation.…”

Section: Discussioncontrasting

confidence: 72%

Quality of life, treatment satisfaction, and adherence to treatment in patients with vesicular hand eczema: A cross‐sectional study

et al. 2020

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Background Recurrent vesicular hand eczema frequently has a chronic course and needs long‐term treatment. Objectives To evaluate health‐related quality of life (HRQoL), treatment satisfaction, and adherence in patients with vesicular hand eczema. Methods Patients using one main treatment for at least three months were included. Data on HRQoL (Quality of Life in Hand Eczema Questionnaire [QOLHEQ]), treatment satisfaction (Treatment Satisfaction Questionnaire for Medication, version II), and treatment adherence (4‐item Morisky Medication Adherence Scale) were collected. Univariate and multivariate regression analysis were used to predict variables associated with HRQoL. Results HRQoL was moderately impaired, with the highest impact in the QOLHEQ subdomain symptoms. Female sex, more severe hand eczema, and lower treatment satisfaction were associated with more impairment in HRQoL. Patients with severe/very severe hand eczema had significant lower “global satisfaction” scores compared with the other severity groups. The “global satisfaction” and treatment adherence in patients using systemic treatment were significantly higher compared with those with only topical treatment. Conclusions In patients with vesicular hand eczema disease severity affects both HRQoL and treatment satisfaction. Systemic treatment of severe hand eczema could improve the severity and as a result also HRQoL, treatment satisfaction, and medication adherence.

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Section: Discussioncontrasting

confidence: 72%

Quality of life, treatment satisfaction, and adherence to treatment in patients with vesicular hand eczema: A cross‐sectional study

et al. 2020

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“…Although not directly comparable, stress has been shown to be linked with a poor prognosis of other chronic dermatoses, such as AD, and the immunological reaction to psychological stress has been demonstrated to be altered in patients with AD, with stress modulating immunological mechanisms in ways that increase eczema severity . However, with regard to the severity of hand eczema, some studies did not find an association with stress, and as hand eczema is known to affect the psychological well‐being and quality of life of patients, it cannot be ruled out that persistence of hand eczema in itself may enhance stress levels and thereby strengthen the association of hand eczema and experienced stress.…”

Section: Discussionmentioning

confidence: 99%

Factors influencing prognosis for occupational hand eczema: new trends

et al. 2019

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Summary Background Variables traditionally reported to influence the prognosis of occupational hand eczema (OHE) are atopic dermatitis (AD) and contact sensitization. However, recent studies indicate that lifestyle factors may be of major importance. Objectives To identify factors influencing the prognosis in a cohort of patients with recognized OHE. Methods In this register‐based cohort study, individuals with hand eczema recognized as occupational disease in the period January 2010–December 2011 were identified using files from Labor Market Insurance Denmark and included in the study. At baseline, information on sex, age, occupation, wet work, AD and contact sensitization was collected. In 2015 participants received a questionnaire with questions about lifestyle factors, current occupation and healing of OHE. Results In total, 2703 patients received the questionnaire; 1491 responded to the question about healing of OHE and were included in the study. Altogether, 19·3% of patients reported complete healing at follow‐up. Current tobacco smoking and a high level of stress were factors inversely associated with healing of hand eczema (P < 0·001 and P = 0·030, respectively), while a high level of exercise was significantly related to healing of eczema (P = 0·011). Change of profession was a favourable prognostic factor, while age, sex, AD, contact sensitization and education did not significantly influence prognosis. Conclusions Traditionally important risk factors such as AD and contact sensitization had no marked influence on prognosis, while lifestyle factors were of major importance. Our findings indicate that risk factors may vary over time, allowing for new perspectives on prevention. What's already known about this topic? Occupational hand eczema has a relapsing course and a poor overall prognosis. Atopic dermatitis and contact sensitization have previously been reported as risk factors for a poor prognosis. What does this study add? The results indicate that lifestyle factors are of importance for the prognosis of occupational hand eczema. Traditionally reported risk factors such as atopic dermatitis and contact sensitization do not currently influence prognosis.

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“…[1][2][3][4] While there is a growing body of research on this topic, it is striking that almost all studies exploring the mental burden of skin diseases focused on assessing mental disorders. 2,[5][6][7] However, considering the World Health Organization's (WHO) definition of health as a 'state of well-being and not merely the absence of disease', 8 such studies are only able to provide a partial assessment of the full mental burden of skin diseases. Studies measuring mental health in terms of subjective well-being are almost absent in dermatologic research so far.…”

Section: Introductionmentioning

confidence: 99%

Happiness in dermatology: a holistic evaluation of the mental burden of skin diseases

Schuster

Ziehfreund

Albrecht

et al. 2020

Acad Dermatol Venereol

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Background According to the World Health Organization, mental health is a state of well-being and not merely the absence of disease. However, studies exploring subjective well-being in patients with skin diseases are very rare. Objectives To assess subjective well-being, i.e. 'happiness', in patients with different skin diseases and to compare them to other patient groups and healthy controls. Methods A cross-sectional study was conducted from 12/2017 to 04/2019. Patients receiving in-or outpatient care for psoriasis, atopic eczema, nummular eczema, mastocytosis, skin cancer (malignant melanoma and keratinocyte carcinoma), human immunodeficiency virus (HIV) or chronic inflammatory bowel diseases (Crohn's disease and ulcerative colitis) were recruited at two hospitals in Bavaria, Germany. Healthy individuals living in or near Munich served as a control group. All participants filled in a questionnaire assessing happiness, measured as positive affect (PA), negative affect and satisfaction with life (SWL; together representing subjective well-being) and a heuristic evaluation of one's own happiness. Results Data from 229 dermatologic patients (53.3 AE 18.5 years, 48% women), 49 patients with inflammatory bowel diseases (48.9 AE 18.7 years, 43% women), 49 patients with HIV (46 AE 10.1 years, 10% women) and 106 healthy controls (38.4 AE 13.4 years, 49% women) were analysed. Compared to the controls, dermatologic patients reported lower heuristic happiness (P = 0.023) and PA (P = 0.001) but higher SWL (P = 0.043). Patients with psoriasis and atopic eczema reported the lowest happiness, as they reported significantly lower PA (P = 0.032 and P < 0.001) and heuristic happiness (P = 0.002 and P = 0.015) than the control group. Patients with skin cancer reported higher SWL than the control group (P = 0.003). Dermatologic patients reported lower happiness than patients with HIV but reported greater happiness than patients with IBD. Conclusions Dermatologic patients experience lower levels of happiness, especially PA, compared to healthy controls. As PA is linked to desirable health outcomes, targeting PA could be a promising holistic approach for the treatment of skin diseases.

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The psychosocial burden of hand eczema: Data from a European dermatological multicentre study

Abstract: This study identifies a specific psychological burden experienced by hand eczema patients, highlighting the need for focused psychosocial interventions. Physicians in particular should be aware of the need to identify anxiety and depression in female patients.

Cited by 33 publications

References 39 publications

Quality of life, treatment satisfaction, and adherence to treatment in patients with vesicular hand eczema: A cross‐sectional study

Quality of life, treatment satisfaction, and adherence to treatment in patients with vesicular hand eczema: A cross‐sectional study

Factors influencing prognosis for occupational hand eczema: new trends

Happiness in dermatology: a holistic evaluation of the mental burden of skin diseases

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