The Psychosocial and Functional Impact of Radiation Therapy

Purnell, Jason Q.; Mustian, Karen M.; Jean‐Pierre, Pascal; Palesh, Oxana; Peppone, Luke Joseph; Mohile, Supriya G.; Darling, Tom V.; Morrow, Gary R.

doi:10.1007/978-3-540-72314-1_17

Cited by 5 publications

(5 citation statements)

References 143 publications

(148 reference statements)

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“…While the prevalence of sleep problems is highest during chemotherapy, research shows that sleep problems continue through cancer survivorship and often persist for years after the completion of cancer therapy 18. One study reported that 57% of long-term (>5 years) lung cancer survivors had poor sleep compared to 30% of non-cancer controls 19.…”

Section: Sleep Problems Throughout the Cancer Trajectorymentioning

confidence: 99%

Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer

Palesh¹,

Peppone²,

Innominato³

et al. 2012

NSS

Self Cite

125

122

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Sleep problems are highly prevalent in cancer patients undergoing chemotherapy. This article reviews existing evidence on etiology, associated symptoms, and management of sleep problems associated with chemotherapy treatment during cancer. It also discusses limitations and methodological issues of current research. The existing literature suggests that subjectively and objectively measured sleep problems are the highest during the chemotherapy phase of cancer treatments. A possibly involved mechanism reviewed here includes the rise in the circulating proinflammatory cytokines and the associated disruption in circadian rhythm in the development and maintenance of sleep dysregulation in cancer patients during chemotherapy. Various approaches to the management of sleep problems during chemotherapy are discussed with behavioral intervention showing promise. Exercise, including yoga, also appear to be effective and safe at least for subclinical levels of sleep problems in cancer patients. Numerous challenges are associated with conducting research on sleep in cancer patients during chemotherapy treatments and they are discussed in this review. Dedicated intervention trials, methodologically sound and sufficiently powered, are needed to test current and novel treatments of sleep problems in cancer patients receiving chemotherapy. Optimal management of sleep problems in patients with cancer receiving treatment may improve not only the well-being of patients, but also their prognosis given the emerging experimental and clinical evidence suggesting that sleep disruption might adversely impact treatment and recovery from cancer.

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Section: Sleep Problems Throughout the Cancer Trajectorymentioning

confidence: 99%

Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer

Palesh¹,

Peppone²,

Innominato³

et al. 2012

NSS

Self Cite

125

122

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“…34 The total score ranges from 0 to 28. ISI score is interpreted as follows: no clinically significant insomnia (0-7), subthreshold insomnia (8)(9)(10)(11)(12)(13)(14), moderate insomnia (15-21), and severe insomnia (22)(23)(24)(25)(26)(27)(28). ISI has favorable internal consistency (Cronbach's alpha of .9) and good construct validity for diagnosing insomnia in cancer patients.…”

Section: Interventionsmentioning

confidence: 99%

“…If not appropriately treated, it can persist for years after completion of cancer treatments. 12 In conventional medicine, insomnia is commonly treated with hypnotic medications (eg, benzodiazepines and non-benzodiazepines). Although sleep medications are recommended for short-term use, some studies showed that 28% to 39% of cancer patients still used it 1-year following chemotherapy completion 13 or 9-years post cancer diagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…Although sleep medications are recommended for short-term use, some studies showed that 28% to 39% of cancer patients still used it 1-year following chemotherapy completion 13 or 9-years post cancer diagnosis. 12 As long-term use of sleep medications can lead to undesirable side effects such as addiction and tolerance, 14 it has been suggested that non-pharmacological therapies, such as cognitive behavioral therapy and acupuncture, are the treatment of choice for insomnia in cancer patients. [15][16][17] Acupuncture has been used for thousands of years in China and other Asian countries to treat various diseases, including sleep disturbance.…”

Section: Introductionmentioning

confidence: 99%

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Electroacupuncture Plus Auricular Acupressure on Chemotherapy-Related Insomnia in Patients With Breast Cancer (EACRI): Study Protocol for a Randomized, Sham-Controlled Trial

Zhang

Yang

et al. 2021

Integr Cancer Ther

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Objective Insomnia is a highly prevalent and disturbing symptom in breast cancer patients under or post chemotherapy. If not appropriately treated, it can persist for years after the completion of cancer treatments. Acupuncture has been widely used for alleviating insomnia. The aim of this study is to examine the feasibility, efficacy and safety of acupuncture for chemotherapy-related insomnia among patients with breast cancer. Materials and Methods This is a trial protocol for a randomized, sham-controlled, subject- and assessor-blinded clinical trial. A total of 138 eligible participants will be assigned randomly to acupuncture or sham control group at a ratio of 1:1. Participants in acupuncture group will receive electroacupuncture (EA) plus auricular acupressure (AA) treatment, while subjects in sham acupuncture group will receive sham EA plus sham AA. Both acupuncture and sham treatments will be given twice weekly for 6 weeks, followed by maintenance treatments once every 4 weeks for 12 weeks (15 sessions totally). The primary outcome is the change of Insomnia Severity Index score between baseline and the end of 6-week treatment. Secondary outcome measurements include Actiwatch, sleep diary, Pittsburgh Sleep Quality Index, Functional Assessment of Cancer Therapy-Breast Cancer, Hospital Anxiety and Depression Scale, Brief Pain Inventory-Short Form, Brief Fatigue Inventory, Acupuncture Expectancy Scale, credibility, and adverse events. Participants will be followed up to 42 weeks. Conclusions This trial will expand our understanding of the feasibility, efficacy, and safety of acupuncture as a treatment for alleviating chemotherapy-related insomnia in patients with breast cancer. EA plus AA, if proven to be effective, can be implemented into routine settings to play a role in insomnia management for patients with breast cancer.

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“… 4 , 8 , 9 If not appropriately treated, it can persist for years after completion of chemotherapy. 10 …”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture Plus Auricular Acupressure for Chemotherapy-Associated Insomnia in Breast Cancer Patients: A Pilot Randomized Controlled Trial

Zhang

Qin

et al. 2021

Integr Cancer Ther

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Objective: Chemotherapy-associated insomnia is a highly prevalent complaint in breast cancer patients. This study was undertaken to evaluate the safety, feasibility, and preliminary effectiveness of electroacupuncture plus auricular acupressure for chemotherapy-associated insomnia in patients with breast cancer. Materials and Methods: In this randomized, wait-list controlled trial, thirty breast cancer patients under or post chemotherapy with insomnia were randomly allocated to the acupuncture or wait-list control group. Participants in acupuncture group received electroacupuncture plus auricular acupressure treatment twice weekly for 6 weeks. Participants in wait-list group received the same regimen of treatment after 6-week of waiting period. Insomnia Severity Index (ISI) served as the primary outcome measurement. Secondary outcomes were sleep parameters recorded with sleep diary and actiwatch, as well as the scores of Pittsburgh Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale (HADS), and Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B). Results: Twenty-eight participants completed study (13 in the acupuncture group vs 15 in the wait-list control group). At week-6 post-intervention, ISI score change from baseline showed significant between-group difference favoring acupuncture group of −2.9 points (95% CI: −5.2 to −0.6, P = .014). The acupuncture group showed greater improvements in the total sleep time recorded by sleep diary ( P = .026), scores of PSQI ( P = .012), HADS-depression ( P = .020), and FACT-B ( P < .001) compared with the control group. Improvements were maintained at week-10 and week-14 follow-ups. Conclusions: Acupuncture is safe, feasible, and effective for chemotherapy-associated insomnia in breast cancer patients under or post chemotherapy. A larger sample size randomized clinical trial is warranted to confirm the present findings. Clinical Trial Registration: NCT03762694.

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The Psychosocial and Functional Impact of Radiation Therapy

Cited by 5 publications

References 143 publications

Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer

Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer

Electroacupuncture Plus Auricular Acupressure on Chemotherapy-Related Insomnia in Patients With Breast Cancer (EACRI): Study Protocol for a Randomized, Sham-Controlled Trial

Electroacupuncture Plus Auricular Acupressure for Chemotherapy-Associated Insomnia in Breast Cancer Patients: A Pilot Randomized Controlled Trial

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