The Psychosis of Sleep Deprivation

West, Louis Jolyon; Janszen, Herbert H.; Lester, Boyd K.; Cornelisoon, Floyd S.

doi:10.1111/j.1749-6632.1962.tb50101.x

Cited by 108 publications

(28 citation statements)

References 8 publications

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“…Low quality of sleep may cause non-dipping, due to agitation or similar symptoms of sleep deprivation, [14] which may furthermore cause psychosis. [22] Yet no difference in sleep duration for dippers vs. non-dippers was found in this study. However, a more robust sleep quality instrument such as the Pittsburgh sleep quality index (PSQI) [45] and/or objective sleep laboratory measurements might have given better insight into sleep quality.…”

Section: Discussioncontrasting

confidence: 37%

“…For example, one of the most significant side effects of levodopa is psychosis [21] but only 16% of patients with dopamine agonist or levodopa medications develop drug-induced psychosis. [18] Other causes of psychosis could be low quality of sleep [22], which is however also likely to cause non-dipping. [14] Up to 90% of PD patients suffer from sleep disruption [23,24] which may be caused by the hallmark PD pathophysiology of dopamine depletion which plays a crucial role in sleep regulation and circadian homeostasis [23].…”

Section: Introductionmentioning

confidence: 99%

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Non-dipping nocturnal blood pressure and psychosis parameters in Parkinson disease

et al. 2015

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Financial disclosure:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.Funding sources for study: None 2Background: Non-motor symptoms are increasingly recognized in Parkinson's Disease (PD) and include physical as well as psychological symptoms. A psychological condition that has been well studied in PD is psychosis.Cardiovascular autonomic dysfunction in PD can include a reversed or lack of blood pressure (BP) circadian rhythm, referred to as nocturnal non-dipping. The aim of this study was to determine the relationship between 24 hr ambulatory blood pressure measurements (ABPM), e.g., absence or presence of nocturnal dipping, and psychosis scores in PD.Methods: 21 patients with Parkinson's disease underwent 24 hr ABPM using an autonomic protocol. A decrease in nocturnal mean arterial blood pressure (MAP) of less than 10% was defined as non-dipping. Patients were interviewed (including the Brief Psychiatric Rating Scale; BPRS) for the assessment of psychosis.Results: 11 patients were dippers and 10 were non-dippers. BPRS scores were higher in non-dippers who on average met the criteria for psychosis (mean non-dipper BPRS: 34.3± 7,3 vs mean dipper BPRS: 27.5 ±5,3; cut off for "mildly ill" 31). There was a correlation between BPRS scores and non-dipping, indicating that those patients who had a blunted nocturnal fall in BP were more prone to psychotic symptoms.(Pearson's Correlation = .554, p =.009). Conclusion:These results suggest that a blunted BP rhythm in Parkinson's disease patients may possibly be associated with psychosis symptoms compared to patients whose BP decreases physiologically at night. This association warrants further investigation.3

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Section: Discussioncontrasting

confidence: 37%

Section: Introductionmentioning

confidence: 99%

Non-dipping nocturnal blood pressure and psychosis parameters in Parkinson disease

et al. 2015

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“…Sleep deprivation in healthy individuals shares many similarities to clinical manifestations observed in schizophrenia. Sleep deprivation can This article is part of the Topical Collection on Sleep Disorders cause psychotic features such as perceptual alterations and paranoia [20,21], severe cognitive impairments [22][23][24], reduced frontal cortical and thalamic metabolism [25] and functional connectivity [26], increased proinflammatory cytokine production [27], and altered cortisol and melatonin levels [28]. Sleep problems are also a major contributor to obesity and cardiovascular illness [29], which are highly prevalent in schizophrenia [30].…”

Section: Introductionmentioning

confidence: 99%

Sleep Disorders Among People With Schizophrenia: Emerging Research

Klingaman

Palmer-Bacon

Bennett

et al. 2015

Curr Psychiatry Rep

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Up to 80 % of individuals with schizophrenia spectrum disorders experience sleep disturbances, which impact physical and mental health, as well as quality of life. In this paper, we review and integrate emerging literature, published between 2012 and 2014, regarding approaches to diagnosis and treatment of major sleep disorders for people with schizophrenia spectrum disorders, including insomnia, obstructive sleep apnea (OSA), circadian rhythm dysfunction, and restless legs syndrome (RLS). We advocate for (1) the need to evaluate the utility of nonpharmacological approaches in people with schizophrenia spectrum disorders; (2) documentation of guidelines to assist providers in clinically tailoring such interventions when their clients experience positive, negative, and/or cognitive symptoms; (3) research on the best ways providers can capitalize on clients' self-identified needs and motivation to engage in sleep treatments through shared decision making; and (4) the importance of investigating whether and how mental health and sleep treatment services should be better connected to facilitate access for people with schizophrenia spectrum disorders. Assessment and tailored treatment of sleep disorders within mental health treatment settings has the potential to reduce sleep problems and improve functioning, quality of life, and recovery of this population.

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“…Sleep deprivation has been known to induce perceptual anomalies such as hallucinations (West et al, 1962). More recently, Sheaves et al (2016) showed that insomnia was associated with perceptual anomalies (hallucinations), even after controlling for negative emotions.…”

Section: Introductionmentioning

confidence: 99%

Sleep quality and paranoia: The role of alexithymia, negative emotions and perceptual anomalies

Rehman

Gumley

Biello

2018

Psychiatry Research

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A B S T R A C TRecent evidence suggests that sleep problems are associated with psychotic like experiences including paranoia. However, the mechanisms underpinning this association are not well understood and thus studies modelling hypothesised mediating factors are required. Alexithymia, the inability to recognise and describe emotions within the self may be an important candidate. In two separate studies we sought to investigate factors mediating the relationship between sleep quality and paranoia using a cross-sectional design. Healthy volunteers without a mental health diagnosis were recruited (study 1, N = 401, study 2, N = 402). Participants completed a series of measures assessing paranoia, negative emotions, alexithymia and perceptual anomalies in an online survey. In study 1, regression and mediation analyses showed that the relationship between sleep quality and paranoia was partially mediated by alexithymia, perceptual anomalies and negative affect. In contrast, study 2 found that the relationship between sleep quality and paranoia was fully mediated by negative affect, alexithymia and perceptual anomalies. The link between sleep quality and paranoia is unclear and reasons for discrepant results are discussed. Novel findings in this study include the link between alexithymia and paranoia.

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The Psychosis of Sleep Deprivation

Cited by 108 publications

References 8 publications

Non-dipping nocturnal blood pressure and psychosis parameters in Parkinson disease

Non-dipping nocturnal blood pressure and psychosis parameters in Parkinson disease

Sleep Disorders Among People With Schizophrenia: Emerging Research

Sleep quality and paranoia: The role of alexithymia, negative emotions and perceptual anomalies

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