The psychopharmacology of primary and metastatic brain tumors and paraneoplastic syndromes

Madhusoodanan, Subramoniam; Ting, Mark Bryan; Wilson, Stephanie Young

doi:10.1016/b978-0-444-64012-3.00016-2

Cited by 2 publications

(3 citation statements)

References 72 publications

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“…Some common psychiatric symptoms are seen more often in certain brain area tumors. For example, It can be symptoms such as disinhibition in orbitofrontal region tumors, apathy, mania or psychosis in medial frontal tumors, psychosis in the tumors which affects third ventricle and surrounding structures [4]. In diencephalon and pituitary gland tumors, vegetative symptoms can be seen as a variant of depressive disorders [16].…”

Section: Discussionmentioning

confidence: 99%

“…The localization of tumor, its edema and mass effect cause the dysfunction of neuronal foci and therefore psychiatric symptoms occur [3]. While a tumor in the dorsolateral prefrontal region may lead to deficiencies in executive function, a tumor in the orbitofrontal region may lead to disinhibition, medial-frontal region tumor may lead apathy and amotivation and temporal limbic tumors may lead to psychosis [4]. Approximately 90% of brain tumors that cause psychiatric symptoms are located in the frontal lobe.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Majör depresif bozukluk belirtileri ile başvuran olfaktör oluk menenjiyomu: Bir olgu sunumu

Egeli

Kapici

Kalenderoğlu

et al. 2020

Archives of Clinical and Experimental Medicine

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Brain tumors without giving neurological symptoms yet; it can also occur with a wide range of psychiatric symptoms such as anxiety, panic attacks, depression, eating disorders, personality change, vision hallucinations and mania. Unfortunately, the diagnosis of brain tumor might be delayed in patients whose clinical symptoms are like these. Brain imaging techniques should be performed especially in patients who don't respond to psychiatric drug treatment and have no neurological symptoms. In this article, a female patient who presented to our psychiatry outpatient clinic with symptoms of depression, accompanied by psychosis symptoms in later periods, and whose mass was detected as a result of magnetic resonance imaging, is discussed in the light of literature studies. Here, we aimed to emphasize the importance of neurological examination and brain imaging methods in patients who come to psychiatry especially with atypical symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Majör depresif bozukluk belirtileri ile başvuran olfaktör oluk menenjiyomu: Bir olgu sunumu

Egeli

Kapici

Kalenderoğlu

et al. 2020

Archives of Clinical and Experimental Medicine

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“…Computed tomography (CT) and magnetic resonance imaging (MRI) remain the most widely used imaging techniques. Positron emission tomography (PET) and single-photon emission computed tomography are used to evaluate the primary tumor site and to identify other possible metastases (1,25) . Two MRI sequences, namely, diffusion-weighted MRI and diffusiontensor imaging, can reveal the microstructure of the brain and its deterioration caused by tumor growth and edema (15) .…”

Section: Introductionmentioning

confidence: 99%

Surgical Management and Postoperative Outcome in patients with Brain Metastases: Our Surgical Experience

Doğan

Durmaz²,

Gezgin

et al. 2022

Sinir Sistemi Cerrahisi Derg

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Aims: Metastatic brain tumors are the most commonly seen intracranial lesion in adults and an important cause of morbidity and mortality in patients with cancer. This study aimed to evaluate the postoperative mortality, morbidity, and survival rates of patients who underwent surgery in our clinic for metastatic brain tumorsMethod: Clinical data of 131 patients, including age, sex, symptoms, localization, primer site, surgical methods, resection, complications and recurrence were collected.Results: Fifty patients (38.1%) were female, and 81 (61.8%) patients were male. The average age of the patients was 54,9. The most common reason for hospital admission was headache (68.7%). Lesions were detected in the cerebral hemisphere in 108 (82.4%) patients and the posterior fossa in 23 (17.5%) patients, and 16 (12.2%) patients had multiple lesions. All patients (n=131) underwent surgery with neuronavigation. Total resection was performed in 25 (19%) patients, gross total resection in 83 (63.3%), subtotal resection in 18 (13.7%), and biopsy in 5 (3.8%). The most commonly seen tumor originated from the lungs (n=63, 48%), according to the histopathological examination. The mean overall survival was 5.3 (range, 1–36) months during the follow-up period. Twelve (9.1%) patients had recurrence and underwent surgery again.Conclusion: Multidisciplinary treatment methods are used in the treatment of metastatic brain tumors. Effective surgical intervention to eliminate peritumoral edema and increased intracranial pressure improves postoperative survival rates. In addition, post-surgical whole-brain radiotherapy reduces recurrence and improves survival.

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The psychopharmacology of primary and metastatic brain tumors and paraneoplastic syndromes

Cited by 2 publications

References 72 publications

Majör depresif bozukluk belirtileri ile başvuran olfaktör oluk menenjiyomu: Bir olgu sunumu

Majör depresif bozukluk belirtileri ile başvuran olfaktör oluk menenjiyomu: Bir olgu sunumu

Surgical Management and Postoperative Outcome in patients with Brain Metastases: Our Surgical Experience

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