The pseudogene GBP1P1 suppresses influenza A virus replication by acting as a protein decoy for DHX9
Xiaohang Yu,
Jiaxin Tian,
Yihe Wang
et al.
Abstract:Recently, substantial evidence has demonstrated that pseudogene-derived long noncoding RNAs (lncRNAs) as regulatory RNAs have been implicated in basic physiological processes and disease development through multiple modes of functional interaction with DNA, RNA, and proteins. Here, we report an important role for GBP1P1, the pseudogene of guanylate-binding protein 1, in regulating influenza A virus (IAV) replication in A549 cells. GBP1P1 was dramatically upregulated after IAV infection, which is controlled by … Show more
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