The proximal probe in esophageal pH monitoring: Development of a normative database

Vincent, Daniel A.; Garrett, J. V.; Radionoff, Sharon L.; Reussner, Lee A.; Stasney, C. Richard

doi:10.1016/s0892-1997(00)80033-8

Cited by 94 publications

(121 citation statements)

References 11 publications

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“…Although it is on asymptomatic subjects, we found abnormal pH monitoring at the distal level in 27 out of 118 subjects with valid studies (22.9%), and they were excluded for the study at the proximal level. Our results in the upper oesophagus are similar to that of previously published data (5,6) and show that the existence of reflux at proximal level is an uncommon phenomenon and very variable throughout the day (2.7). The determination of pH at this level in healthy volunteers also has a good reproducibility.…”

Section: Discussionsupporting

confidence: 92%

“…However, it must always be borne in mind that the comparison is not easy for the technical and/or methodological differences already mentioned. The elimination of meal periods and pseudo-reflux events provides a more adjusted vision to the reality of the small size that the gastro-oesophageal (in the upper oesophagus) or gastro-pharyngeal reflux have in healthy subjects as shown in table III (5,6,9,18,23,29). As occurs in the lower oesophagus, the number of reflux episodes has limited value because its low reproducibility (2,24), while the most useful parameter is the % time with pH < 4.…”

Section: Discussionmentioning

confidence: 99%

“…It is generally accepted that the reflux episode suffers an almost linear decrease of the pH as it rise to the hypopharynx (1,5,6,19,30) and it is likely that at the proximal level, the episodes are weakly acidic. However, other cut-off points with pH > 4 have been little studied (2,7,10).…”

Section: Discussionmentioning

confidence: 99%

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Normal values in ambulatory oesophageal pH monitoring at two levels in Spain

Digestiva¹,

Azpiroz²,

Baudet³

et al. 2010

Rev. esp. enferm. dig.

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Aim: upper oesophageal pH monitoring may play a significant role in the study of extra-oesophageal GERD, but limited normal data are available to date. Our aim was to develop a large series of normal values of proximal oesophageal acidification.Methods: 155 healthy volunteers (74 male) participated in a multi-centre national study including oesophageal manometry and 24 hours oesophageal pH monitoring using two electrodes individually located 5 cm above the LOS and 3 cm below the UOS.Results: 130 participants with normal manometry completed all the study. Twelve of them were excluded for inadequate pH tests. Twenty-seven subjects had abnormal conventional pH. The remaining 91 subjects (37 M; 18-72 yrs age range) formed the reference group for normality. At the level of the upper oesophagus, the 95 th percentile of the total number of reflux events was 30, after eliminating the meal periods 22, and after eliminating also the pseudo-reflux events 18. Duration of the longest episodes was 5, 4 and 4 min, respectively (3.5 min in upright and 0.5 min in supine). The upper limit for the percentage of acid exposure time was 1.35, 1.05 and 0.95%, respectively. No reflux events were recorded in the upper oesophagus in 8 cases.Conclusion: this is the largest series of normal values of proximal oesophageal reflux that confirm the existence of acid reflux at that level in healthy subjects, in small quantity and unrelated to age or gender. Our data support the convenience of excluding pseudo-reflux events and meal periods from analysis.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Normal values in ambulatory oesophageal pH monitoring at two levels in Spain

Digestiva¹,

Azpiroz²,

Baudet³

et al. 2010

Rev. esp. enferm. dig.

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“…Another notable aspect of the Na ϩ channel in ESSE is that in vivo in humans it is exposed to high levels of acidity because of repeated daily exposure to refluxates from the stomach whose pHs may attain values as low as pH ϳ1.0. Moreover, esophageal pH monitoring has documented that acid reflux extends well beyond the distal esophagus and into the proximal esophagus in both healthy subjects (adults and children) and subjects with gastroesophageal reflux disease (5,7,36), with proximal reflux being much more common in the postprandial period and when ambulatory rather than sedentary (10). In one recent report, 39% of 130 patients suspected of having laryngopharyngeal reflux had pathological proximal esophageal acidity on pH monitoring (35).…”

mentioning

confidence: 99%

Effect of luminal acidity on the apical cation channel in rabbit esophageal epithelium

Tobey

Argote

Awayda

et al. 2007

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…26 Vincent et al 27 concluded that the reflux index is the most useful single parameter for diagnosing GER in patients with respiratory symptoms.…”

Section: Study Protocolmentioning

confidence: 99%

Refluxo gastroesofágico e asma na infância: um estudo de sua relação através de monitoramento do pH esofágico

Teixeira¹,

Norton²,

Penna³

et al. 2007

J. Pediatr. (Rio J.)

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Objectives: This study aims at verifying the prevalence of gastroesophageal reflux in asthmatic children, and at determining the sensitivity and specificity of the reflux index for the diagnosis of gastroesophageal reflux disease.Methods: Sixty-nine children, aged 1-5 years, with asthma, were studied by 24-hour pH monitoring. The patients were randomly selected.Results: Ages varied from 12.4 to 63.1 months, mean age = 30.79 months, and 62.3% were males.Gastroesophageal reflux was observed in 68.1% of the children. The patients were divided into two groups, moderate and severe asthma, and gastroesophageal reflux was diagnosed in 58.5 and 82.1% of the cases, respectively. Occult gastroesophageal reflux occurred in 31.8% of the cases. The reflux index showed an sensitivity of 89.4%, specificity of 95.5%, positive predictive value of 97.7% and negative predictive value of 80.8%. Conclusions:The results of this study indicate a relationship between gastroesophageal reflux and asthma, and suggest that the reflux index as a single parameter of pH monitoring has good sensitivity and specificity for the diagnosis of gastroesophageal reflux disease.J Pediatr (Rio J). 2007;83(6):535-540: Asthma, gastroesophageal reflux, child, pH monitoring.

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The proximal probe in esophageal pH monitoring: Development of a normative database

Cited by 94 publications

References 11 publications

Normal values in ambulatory oesophageal pH monitoring at two levels in Spain

Normal values in ambulatory oesophageal pH monitoring at two levels in Spain

Effect of luminal acidity on the apical cation channel in rabbit esophageal epithelium

Refluxo gastroesofágico e asma na infância: um estudo de sua relação através de monitoramento do pH esofágico

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