The PROTON study: profiles of blood product transfusion recipients in the Netherlands

Borkent-Raven, B. A.; Janssen, Mart P.; Poel, C.L. van der; Schaasberg, W.; Bonsel, Gouke J.; Hout, Ben A. van

doi:10.1111/j.1423-0410.2010.01312.x

Cited by 73 publications

(110 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The data obtained in our retrospective analysis are in agreement with previously published results concerning the overall blood consumption of RBC, FFP and PLT units in cardiac surgery [1,2,3,4,5,6,13]. The percentage of patients requiring RBC, FFP or PLT units noticeably decreased after the introduction of the PBM measures in January 1, 2012, whereas significantly more blood (RBCs) per patient was provided in 2012 (7,253 RBC units) compared to 2009 (5,998 RBC units), which might reflect the above mentioned complexity factor.…”

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

Utilisation of Blood Components in Cardiac Surgery: A Single-Centre Retrospective Analysis with Regard to Diagnosis-Related Procedures

Geissler

Rotering

Buddendick

et al. 2015

Transfus Med Hemother

View full text Add to dashboard Cite

Background: More blood components are required in cardiac surgery than in most other medical disciplines. The overall blood demand may increase as a function of the total number of cardiothoracic and vascular surgical interventions and their level of complexity, and also when considering the demographic ageing. Awareness has grown with respect to adverse events, such as transfusion-related immunomodulation by allogeneic blood supply, which can contribute to morbidity and mortality. Therefore, programmes of patient blood management (PBM) have been implemented to avoid unnecessary blood transfusions and to standardise the indication of blood transfusions more strictly with aim to improve patients' overall outcomes. Methods: A comprehensive retrospective analysis of the utilisation of blood components in the Department of Cardiac Surgery at the University Hospital of Münster (UKM) was performed over a 4-year period. Based on a medical reporting system of all medical disciplines, which was established as part of a PBM initiative, all transfused patients in cardiac surgery and their blood components were identified in a diagnosis- and medical procedure-related system, which allows the precise allocation of blood consumption to interventional procedures in cardiac surgery, such as coronary or valve surgery. Results: This retrospective single centre study included all in-patients in cardiac surgery at the UKM from 2009 to 2012, corresponding to a total of 1,405-1,644 cases per year. A blood supply was provided for 55.6-61.9% of the cardiac surgery patients, whereas approximately 9% of all in-patients at the UKM required blood transfusions. Most of the blood units were applied during cardiac valve surgery and during coronary surgery. Further surgical activities with considerable use of blood components included thoracic surgery, aortic surgery, heart transplantations and the use of artificial hearts. Under the measures of PBM in 2012 a noticeable decrease in the number of transfused cases was observed compared to the period from 2009 to 2011 before implementation of the PBM initiative (red blood cells p < 0.002; fresh frozen plasma p < 0.0006; platelets p < 0.00006). Conclusion: Until now, cardiac surgery comes along with a significant blood supply. By using a case-related data evaluation programme, the consumption of each blood component can be linked to clinical performance groups and, if necessary, to individual patients. Based on the results obtained from this retrospective analysis, prospective studies are underway to begin conducting target / actual performance comparisons to better understand the individual decision-making by the attending physicians with respect to transfusions.

show abstract

Section: Discussionsupporting

confidence: 82%

“…In many hospitals that provide comprehensive medical care, the usage of blood components during cardiac surgery is much greater than the average blood product demand in most other medical disciplines [1,2,3,4,5,6]. Today, blood transfusions have become more and more accepted as a major quality indicator in cardiac surgery [7,8,9].…”

Section: Introductionmentioning

confidence: 99%

Utilisation of Blood Components in Cardiac Surgery: A Single-Centre Retrospective Analysis with Regard to Diagnosis-Related Procedures

Geissler

Rotering

Buddendick

et al. 2015

Transfus Med Hemother

View full text Add to dashboard Cite

show abstract

“…Yet, in medical cases the leading diagnoses were bone marrow transplants, diseases of the blood and bloodforming organs, poorly differentiated neoplasms, and HIV infections [11]. The distribution of the three analyzed blood components to the different medical disciplines and gender distribution in the UKM schedule also approximately reflect the findings in publications from the USA [19] and the Netherlands [12]. Most blood components were used in cardiac and thoracic surgery, visceral and trauma surgery, in orthopedics, and in hematology/oncology.…”

Section: Discussionmentioning

confidence: 51%

“…RBCs and FFP were preferably needed in surgical disciplines while PTL were more used in hematology/oncology. Patients with hematology/oncology treatment and cardiac/thoracic surgery did not only need the highest numbers of transfusion units but also received the most intensive hemotherapies, specified as blood products per person [12,19,23]. These findings could PBM initiative and started with first priority a retrospective status quo analysis of the flow of blood components within our institution.…”

Section: Discussionmentioning

confidence: 99%

“…This is the case within the fields of solid organ transplantation and regenerative medicine or for major surgical interventions. It is also typical for hematology and oncology, especially for patients receiving high-dose chemotherapy regimens, which unavoidably lead to an increase in consumption of cellular blood products and fresh frozen plasma [5,11,12]. The increasing use of bone marrow and peripheral blood stem cell transplantations [13] did not unburden the need of blood components.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Retrospective Analysis of the Blood Component Utilization in a University Hospital of Maximum Medical Care

Geissler

Franz²,

Buddendick³

et al. 2012

Transfus Med Hemother

View full text Add to dashboard Cite

Background: Demographic data illustrate clearly that people in highly developed countries get older, and the elderly need more blood transfusions than younger patients. Additionally, special extensive therapies result in an increased consumption of blood components. Beyond that the aging of the population reduces the total number of preferably young and healthy blood donors. Therefore, Patient Blood Management will become more and more important in order to secure an increasing blood supply under fair-minded conditions. Methods: At the University Hospital of Münster (UKM) a comprehensive retrospective analysis of the utilization of all conventional blood components was performed including all medical and surgical disciplines. In parallel, a new medical reporting system was installed to provide a monthly analysis of the transfusional treatments in the whole infirmary, in every department, and in special blood-consuming cases of interest, as well. Results: The study refers to all UKM in-patient cases from 2009 to 2011. It clearly demonstrates that older patients (>60 years, 35.2–35.7% of all cases, but 49.4–52.6% of all cases with red blood cell (RBC) transfusions, 36.4–41. 6% of all cases with platelet (PTL, apheresis only) transfusions, 45.2– 48.0% of all cases with fresh frozen plasma (FFP) transfusions) need more blood products than younger patients. Male patients (54.4–63.9% of all cases with transfusions) are more susceptible to blood transfusions than female patients (36.1–45.6% of all cases with transfusions). Most blood components are used in cardiac, visceral, and orthopedic surgery (49.3–55.9% of all RBC units, 45.8–61.0% of all FFP units). When regarding medical disciplines, most transfusions are administered to hematologic and oncologic patients (12.9–17.7% of all RBC units, 9.2– 12.0% of all FFP units). The consumption of PTL in this special patient cohort (40.6–50.9% of all PTL units) is more pronounced than in all other surgical or in non-surgical disciplines. Conclusion: The results obtained from our retrospective analysis may help to further optimize the responsible and medical indication-related utilization of blood transfusions as well as the recruitment of blood donors and their timing. It may be also a helpful tool in order to avoid needless transfusions and transfusion-associated adverse events.

show abstract

Ever-Pregnant Female Blood Donors and Mortality Risk in Male Recipients

Ali

Wasfi

Uzoigwe³

2018

JAMA

View full text Add to dashboard Cite

The PROTON study: profiles of blood product transfusion recipients in the Netherlands

Abstract: Transfusion data from a limited sample of hospitals can be used to estimate national distributions of blood recipient characteristics.

Cited by 73 publications

References 10 publications

Utilisation of Blood Components in Cardiac Surgery: A Single-Centre Retrospective Analysis with Regard to Diagnosis-Related Procedures

Utilisation of Blood Components in Cardiac Surgery: A Single-Centre Retrospective Analysis with Regard to Diagnosis-Related Procedures

Retrospective Analysis of the Blood Component Utilization in a University Hospital of Maximum Medical Care

Ever-Pregnant Female Blood Donors and Mortality Risk in Male Recipients

Contact Info

Product

Resources

About