“…Amidines are strong bases (pKa ranges from [5][6][7][8][9][10][11][12]. The protonation occurs on the imino nitrogen 4,5 leading to symmetrical amidinium ion 3 which is stabilized by resonance as in the isoelectronic carboxylate anion 4. In a strong acidic media, the dication 5 is formed, which has a localized carbon-nitrogen double bond, whereas in a strong alkaline solution the anion 6 can be formed.…”
The review summarizes literature dealing with the synthesis of amidines and amidrazones including some of their physical and chemical properties along with their applications in heterocycles synthesis.
“…Amidines are strong bases (pKa ranges from [5][6][7][8][9][10][11][12]. The protonation occurs on the imino nitrogen 4,5 leading to symmetrical amidinium ion 3 which is stabilized by resonance as in the isoelectronic carboxylate anion 4. In a strong acidic media, the dication 5 is formed, which has a localized carbon-nitrogen double bond, whereas in a strong alkaline solution the anion 6 can be formed.…”
The review summarizes literature dealing with the synthesis of amidines and amidrazones including some of their physical and chemical properties along with their applications in heterocycles synthesis.
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