The protocols for the 10/66 dementia research group population-based research programme

Abstract

Background: Latin America, China and India are experiencing unprecedentedly rapid demographic ageing with an increasing number of people with dementia. The 10/66 Dementia Research Group's title refers to the 66% of people with dementia that live in developing countries and the less than one tenth of population-based research carried out in those settings. This paper describes the protocols for the 10/66 population-based and intervention studies that aim to redress this imbalance.

Age-Related Metabolic Profiles in Cognitively Healthy Elders: Results from a Voxel-Based [18F]Fluorodeoxyglucose–Positron-Emission Tomography Study with Partial Volume Effects Correction: Fig 1.

“…We cannot discard the presence of underlying degenerative diseases, such as preclinical AD, in some of the subjects included in the sample. To diminish the chance that our findings were secondary to such conditions, we selected the sample investigated among cognitively healthy individuals according to a transcultural protocol developed by the 10/66 Dementia Research Group 27 and tested for APOE genotype, which was included in our analysis as a covariate of no interest. One potential factor that could have influenced the results of our study was the inclusion of subjects with conditions that might affect brain volume and function through vascular changes, such as dyslipidemia and hypertension.…”

“…27 This protocol included the following instruments: the Community Screening Interview for Dementia 28 ; an adapted version of the CERAD 10-word list 29 ; the animal naming verbal fluency task from the CERAD; the Geriatric Mental State 30 ; a structured neurologic assessment; and a structured cardiology evaluation. The criterion for cognitive impairment was defined as a performance in the cognitive battery 1.5 SDs below the mean performance obtained from all subjects between 65 and 75 years of age from the original SPAH sample.…”

Cognitive function and disability in late life: an ecological validation of the 10/66 battery of cognitive tests among community‐dwelling older adults in South India

“…Socio‐demographic questionnaire collecting information on age, sex, marital status, level of education (none; some, but did not complete primary; completed primary; completed secondary; completed tertiary or further education) and living circumstances (living with children, yes/no) (Prince et al ., 2007). …”

“…Stroke was coded only if there was a clear history of sudden onset of unilateral paralysis, loss of speech or blindness lasting for more than 24 h, hence excluding previous episodes of transient ischaemic attack. Chronic obstructive airway disease (COAD) was diagnosed in people who responded ‘yes’ to the question ‘do you usually cough up phlegm from your chest first thing in the morning?’ and whose answer to the question ‘for how many months of the year does this usually happen?’ was 3 months or more (Prince et al ., 2007). …”

“…This is suitable for use in people with little or no education (Prince et al ., 2003). The 10/66 battery of cognitive tests comprises the Community Screening Instrument for Dementia (CSI'D') incorporating the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) animal naming verbal fluency (VF) task, the modified CERAD 10 word list learning task with delayed recall and an informant interview for evidence of cognitive and functional decline (Prince et al ., 2003; Prince et al ., 2007). In the 10/66 pilot studies, the CSI'D', informant interview and the modified CERAD 10 word list learning task were independently able to predict the diagnosis of dementia (Prince et al ., 2003).…”