The Proteomic Landscape of Pancreatic Ductal Adenocarcinoma Liver Metastases Identifies Molecular Subtypes and Associations with Clinical Response—Response

Law, Henry C-H; Clement, Emalie J.; Grandgenett, Paul M.; Hollingsworth, Michael A.; Woods, Nicholas T.

doi:10.1158/1078-0432.ccr-21-1220

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2024

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“…Interestingly, next-generation genome sequencing of patient-matched primary pancreatic and metastatic lesions revealed striking genetic similarities between primary tumors and metastases, 21 underscoring the crucial role of transcriptional and post-transcriptional changes in promoting PDA metastasis. 22 , 23 , 24 , 25 Indeed, global proteomic analysis of human PDA liver metastases revealed four distinct subtypes, 26 laying the groundwork for the potential application of proteomic classification in developing strategies to understand and target PDA metastasis.…”

Section: Introductionmentioning

confidence: 99%