2010
DOI: 10.1002/pmic.201000196
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The proteome of lysosomes

Abstract: Lysosomes are organelles of eukaryotic cells that are critically involved in the degradation of macromolecules mainly delivered by endocytosis and autophagocytosis. Degradation is achieved by more than 60 hydrolases sequestered by a single phospholipid bilayer. The lysosomal membrane facilitates interaction and fusion with other compartments and harbours transport proteins catalysing the export of catabolites, thereby allowing their recycling. Lysosomal proteins have been addressed in various proteomic studies… Show more

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Cited by 193 publications
(167 citation statements)
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“…SLC proteins are responsible for shuttling nutrients across plasma, lysosome, and other organelle membranes (67). Endolysosomal compartments that fuse with the C. burnetii-containing vacuole contain numerous SLC proteins (4,68,69). It is logical to hypothesize that, like Legionella, C. burnetii hijacks host cell peptide or amino acid transport to acquire amino acids needed for growth.…”
Section: Discussionmentioning
confidence: 99%
“…SLC proteins are responsible for shuttling nutrients across plasma, lysosome, and other organelle membranes (67). Endolysosomal compartments that fuse with the C. burnetii-containing vacuole contain numerous SLC proteins (4,68,69). It is logical to hypothesize that, like Legionella, C. burnetii hijacks host cell peptide or amino acid transport to acquire amino acids needed for growth.…”
Section: Discussionmentioning
confidence: 99%
“…Alternatively or additionally, sulfate transport might occur at the lysosomal membrane. Although Sc26a11 subcellular localization in intact tissue remains unknown, the endogenous rat liver protein copurifies with lysosomes (11,42), and the transfected tagged protein largely colocalizes with lysosomes (42). Moreover, lysosomal activation and biogenesis induced in HeLa cells by transient overexpression of transcription factor TFEB increased Slc26A11 mRNA level by fivefold (41).…”
Section: C296mentioning
confidence: 99%
“…Man6P-containing lysosomal proteins have been purified from a wide variety of biological sources, and their characterization by proteomic methods has provided valuable insights into the composition and function of the lysosome as well as the roles of lysosomal proteins in human disease (2,7). In mammals, the tissue distribution of lysosomal proteins can be highly restricted, and thus one approach that has effectively increased proteome coverage has been to analyze multiple individual tissues (3).…”
mentioning
confidence: 99%