The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury

Späth, Martin Richard; Bartram, Malte P.; Palacio-Escat, Nicolàs; Hoyer, K. Johanna R.; Debès, Cédric; Demir, Fatih; Schroeter, Christina B.; Mandel, Amrei M; Grundmann, Franziska; Ciarimboli, Giuliano; Beyer, Andreas; Kizhakkedathu, Jayachandran N.; Brodesser, Susanne; Göbel, Heike; Becker, Jan U.; Benzing, Thomas; Schermer, Bernhard; Höhne, Martin; Burst, Volker; Sáez-Rodríguez, Julio; Huesgen, Pitter F.; Müller, Roman‐Ulrich; Rinschen, Markus M.

doi:10.1016/j.kint.2018.08.037

Cited by 62 publications

(57 citation statements)

References 70 publications

(77 reference statements)

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“…These differences may be due to differences between the species, but additionally, the renal changes associated with the allogeneic rat transplantation model resemble chronic rejection [25] and thus may reflect more immune-driven processes than the present biopsies from stable renal transplant patients. Moreover, a study by Späth et al confirmed our findings on the involvement of proteins related to inflammatory and fibrotic responses in kidney function and fibrosis [26].…”

Section: Discussionsupporting

confidence: 88%

Proteomic Analysis of Renal Biomarkers of Kidney Allograft Fibrosis—A Study in Renal Transplant Patients

Mortensen

Svane

Burton

et al. 2020

IJMS

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Renal transplantation is the preferred treatment of end stage renal disease, but allograft survival is limited by the development of interstitial fibrosis and tubular atrophy in response to various stimuli. Much effort has been put into identifying new protein markers of fibrosis to support the diagnosis. In the present work, we performed an in-depth quantitative proteomics analysis of allograft biopsies from 31 prevalent renal transplant patients and correlated the quantified proteins with the volume fraction of fibrosis as determined by a morphometric method. Linear regression analysis identified four proteins that were highly associated with the degree of interstitial fibrosis, namely Coagulation Factor XIII A chain (estimate 18.7, adjusted p < 0.03), Uridine Phosphorylase 1 (estimate 19.4, adjusted p < 0.001), Actin-related protein 2/3 subunit 2 (estimate 34.2, adjusted p < 0.05) and Cytochrome C Oxidase Assembly Factor 6 homolog (estimate −44.9, adjusted p < 0.002), even after multiple testing. Proteins that were negatively associated with fibrosis (p < 0.005) were primarily related to normal metabolic processes and respiration, whereas proteins that were positively associated with fibrosis (p < 0.005) were involved in catabolic processes, cytoskeleton organization and the immune response. The identified proteins may be candidates for further validation with regards to renal fibrosis. The results support the notion that cytoskeleton organization and immune responses are prevalent processes in renal allograft fibrosis.

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Section: Discussionsupporting

confidence: 88%

Proteomic Analysis of Renal Biomarkers of Kidney Allograft Fibrosis—A Study in Renal Transplant Patients

Mortensen

Svane

Burton

et al. 2020

IJMS

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“…and various recent studies suggested that this effect is evolutionary conserved in a wide variety of species from yeast to mammals including primates. 34 With the likely cause responsible for this phenomenon being a robust and longstanding enhancement of cellular stress resistance 35,36 a short-term protection from acute stressors is achieved by brief periods of DR. With respect to the kidney, Mitchell et al published a proof-of-concept study in a murine renal ischemia reperfusion injury model in which DR conducted for 2 to 4 weeks completely prevented death from AKI and dramatically ameliorated renal failure. 3 Likewise, we showed recently that a 4-week 30%-CR strongly protects from toxic renal failure after cisplatinum application in mice.…”

Section: Discussionmentioning

confidence: 99%

“…3 Likewise, we showed recently that a 4-week 30%-CR strongly protects from toxic renal failure after cisplatinum application in mice. 35 Despite a plethora of studies investigating dietary interventions with respect to weight control, only scarce data is available concerning the impact of DR protocols on organ protection in humans. In a large-scale clinical trial the administration of a calorie-restricted enteral feeding protocol in critically ill patients led to a significantly lower rate of renal replacement therapy.…”

Section: Discussionmentioning

confidence: 99%

Dietary restriction for prevention of contrast-induced acute kidney injury in patients undergoing percutaneous coronary angiography: a randomized controlled trial

Grundmann

Hoyer-Allo

Späth

et al. 2020

Sci Rep

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Short-term dietary restriction (DR) may prevent organ damage from ischemic or toxic insults in animals, but clear evidence in humans is missing. While especially intraarterial administration of contrast media represents a cause of hospital-acquired acute kidney injury (AKi), targeted preventive strategies are not available. This trial investigated the feasibility and effectiveness of pre-interventional DR for preventing AKi in patients undergoing percutaneous coronary intervention (pci). patients were randomized to receive a formula diet containing 60% of daily energy requirement (DR group) or ad-libitum food during the 4-day-interval before PCI. Primary endpoint was change of serum creatinine 48 h after PCI (Δcreatinine). further analyses included incidence of AKi and safety evaluation. Δcreatinine post PCI in the DR group vs. the control group did not show any difference (DR: 0.03(−0.15,0.14)mg/dL vs. control: 0.09(−0.03,0.22)mg/dL;p = 0.797). Subgroup analyses revealed a significant beneficial impact of DR in patients that received ≤100 ml of contrast agent (DR n = 26: Δcreatinine −0.03(−0.20,0.08) mg/dL vs. control n = 24: Δcreatinine 0.10(−0.08,0.24)mg/dL; p = 0.041) and in patients with ≤2 risk factors for AKi (DR: n = 27; Δcreatinine −0.01(−0.18,0.07)mg/dL vs. control n = 31: Δcreatinine 0.09(−0.03,0.16)mg/dl; p = 0.030). Although the primary endpoint was not met, the results of this trial suggest a beneficial impact of DR in low-to-moderate risk patients. Dietary restriction (DR) is characterized by reduced food intake without inducing poor nutrition and subsumes numerous interventions including general calorie restriction (CR), protein restriction (PR) and various fasting protocols. Short-term DR-usually excercised for several days to weeks-has an extraordinary power to reduce cellular damage susceptibility by promoting resistance towards ischemic insults in rodent models of injury to the liver, 1,2 kidney 3,4 brain, 5 and heart. 6 Furthermore, DR has also been proven highly effective in preventing or ameliorating chemotoxic injury to the heart (secondary to doxorubicin) 7 and the kidney (secondary to cisplatinum) 8 and successfully improved survival in a murine chemotoxic stress model. 9 Possible mechanisms contributing to this phenomenon are versatile and include improvement of insulin sensitivity and reduction of oxidative stress and free radical induced damage, as well as modification of DNA repair. Alterations in the mechanistic target-of-rapamycin(mTOR)-signaling and other pathways, such as 5′ adenosine monophosphate-activated

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“…17 Notably, the recovery rates from AKI have not improved significantly over the last 60 years, 18 indicating a small increase in knowledge about the underlying pathogenetic processes. This is remarkable, given the numerous experimental studies dealing with the prevention and treatment of AKI (eg, 4,[19][20][21][22][23][24][25][26][27] ).…”

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confidence: 99%

Metabolic modelling of kidney diseases: Lessons learned from the liver

2019

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The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury

Abstract: The protective effect of preconditioning in cisplatin-induced acute kidney injury is determined by mRNA-independent alterations of the proteome microenvironment

Cited by 62 publications

References 70 publications

Proteomic Analysis of Renal Biomarkers of Kidney Allograft Fibrosis—A Study in Renal Transplant Patients

Proteomic Analysis of Renal Biomarkers of Kidney Allograft Fibrosis—A Study in Renal Transplant Patients

Dietary restriction for prevention of contrast-induced acute kidney injury in patients undergoing percutaneous coronary angiography: a randomized controlled trial

Metabolic modelling of kidney diseases: Lessons learned from the liver

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