The protein tyrosine phosphatase receptor type H, PTPRH, is differentially expressed in the primary tumors of breast cancer patients treated with trastuzumab.
Abstract:Trastuzumab, a monoclonal antibody targeted against the human epidermal growth factor receptor 2 (HER2) is utilized for the treatment of human breast cancer (1, 2), but a complete understanding of how tumor signal transduction is modulated by trastuzumab treatment is lacking. By mining published and public microarray and gene expression data (3, 4) from the primary tumors of patients treated with trastuzumab, we found that the protein tyrosine phosphatase receptor type H, encoded by PTPRH, was among the genes… Show more
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