The protein tyrosine kinase family of the human genome

Robinson, Dan R.; Wu, Yi-Mi; Lin, Su‐Fang

doi:10.1038/sj.onc.1203957

Cited by 970 publications

(669 citation statements)

References 113 publications

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“…71 The RTK subclass III (the PDGFR family) is the best-studied in normal and abnormal hematopoiesis, and is composed of 5 homologous members (CSF1R, FLT3, KIT, PDGFRA, and PDGFRB). [71][72][73] The shared structure includes: five extracellular immunoglobulin-like domains (EMD), a transmembrane domain (TMD), juxtamembrane domain (JMD), two intracellular tyrosine kinase domains (TKD), and a hydrophilic insertion/linker domain between the TKDs (KID). 72,73 Compared to RTKs, CKRs do not have intrinsic tyrosine kinase activity and must recruit kinases to initiate intracellular signaling.…”

Section: Regulation Of Expression Via Cell Membrane Proteinsmentioning

confidence: 99%

“…[71][72][73] The shared structure includes: five extracellular immunoglobulin-like domains (EMD), a transmembrane domain (TMD), juxtamembrane domain (JMD), two intracellular tyrosine kinase domains (TKD), and a hydrophilic insertion/linker domain between the TKDs (KID). 72,73 Compared to RTKs, CKRs do not have intrinsic tyrosine kinase activity and must recruit kinases to initiate intracellular signaling. Two classical examples of hematopoietic CKRs include CSF2R (GM-CSF receptor) and CSF3R (G-CSF receptor).…”

Section: Regulation Of Expression Via Cell Membrane Proteinsmentioning

confidence: 99%

“…59 At the plasma membrane, the extracellular domains of RTKs and CKRs bind specific cytokines or growth factors (Table 1). 72 Ligand binding induces conformational changes that in turn either activate intrinsic kinase activity (RTK only) or recruit cytoplasmic kinases to initiate diverse signal transduction pathways. Therefore, the membrane receptor expression pattern of a specific cell dictates ligand binding and, ultimately, defines the cell responses to the repertoire of ligands in its environment.…”

Section: Regulation Of Expression Via Cell Membrane Proteinsmentioning

confidence: 99%

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Gene expression changes in normal haematopoietic cells

Lionberger¹,

Stirewalt²

2009

Best Practice & Research Clinical Haematology

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The complexity of the healthy hematopoietic system is immense, and as such, one must understand the biology driving normal hematopoietic expression profiles when designing experiments and interpreting expression data that involves normal cells. This chapter seeks to present an organized approach to the use and interpretation of gene profiling in normal hematopoiesis and broadly illustrates the challenges of selecting appropriate controls for high-throughput expression studies.

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Section: Regulation Of Expression Via Cell Membrane Proteinsmentioning

confidence: 99%

Section: Regulation Of Expression Via Cell Membrane Proteinsmentioning

confidence: 99%

Section: Regulation Of Expression Via Cell Membrane Proteinsmentioning

confidence: 99%

See 1 more Smart Citation

Gene expression changes in normal haematopoietic cells

Lionberger¹,

Stirewalt²

2009

Best Practice & Research Clinical Haematology

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“…Receptor tyrosine kinases (RTKs) and their ligands are crucially important for the functional integrity of the vasculature 6,7 . Axl is a member of the TAM family of RTKs, consisting of Tyro3 (Sky), Axl and Mer, and it is expressed in endothelium, vascular smooth muscle cells and fibroblasts of the vessel wall 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Plasma concentrations of growth arrest specific protein 6 and the soluble form of its tyrosine kinase receptor Axl as markers of large abdominal aortic aneurysms

Ekman

Site

Gottsäter

et al. 2010

Clinical Biochemistry

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“…It is estimated that there are 1000 -2000 different protein kinases in the human genome (Hunter and Cooper, 1985;Robinson et al, 2000). Less than 10% of all kinases are protein tyrosine kinases (PTK), but many tyrosine kinases are involved in growth signalling, and alterations of these kinases often result in cellular transformation (Hunter and Cooper, 1985).…”

mentioning

confidence: 99%

Tyrosine-kinase expression profiles in human gastric cancer cell lines and their modulations with retinoic acids

et al. 2003

Br J Cancer

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Many protein tyrosine kinases are key regulators involved in cellular growth, differentiation, development, apoptosis and signal transduction pathways. Obtaining a comprehensive tyrosine-kinase expression profile in tumour cells is essential to learning more about their oncogenic potentials and responses to various chemotherapeutic reagents -such as retinoic acid, which has been shown to suppress the growth of gastric cancer cells and modulate gene expression. Expression of tyrosine kinases in retionic acid-treated cancer cells was investigated by reverse trancriptase -polymerase chain reaction (RT -PCR) and a novel restriction analysis of gene expression (RAGE) display technique. We first established comprehensive tyrosine-kinase profiles in different human gastric cancer cell lines. In cells treated with 9-cis-retinoic acid or all-trans-retinoic acid, we found that two PTKs (Eph and Hek5) appeared to be upregulated. In the present study, we demonstrate an efficient and simple RAGE approach for examining tyrosine kinases' expression in tumour cells and their alterations following drug treatments.

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The protein tyrosine kinase family of the human genome

Cited by 970 publications

References 113 publications

Gene expression changes in normal haematopoietic cells

Gene expression changes in normal haematopoietic cells

Plasma concentrations of growth arrest specific protein 6 and the soluble form of its tyrosine kinase receptor Axl as markers of large abdominal aortic aneurysms

Tyrosine-kinase expression profiles in human gastric cancer cell lines and their modulations with retinoic acids

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