The protein-protein interactions between Amsacta moorei entomopoxvirus (AMEV) protein kinases (PKs) and all viral proteins

Danismazoglu, Mehtap; Nalçacıoğlu, Remziye; Muratoglu, Hacer; Demirbağ, Zihni

doi:10.1016/j.virusres.2018.02.007

Cited by 2 publications

(2 citation statements)

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“…139 F10L is required for early morphogenesis because it interacts with intracellular membranes and assists in the formation of immature virions. 91 Specific B1R and F10L inhibitors may prevent the replication of viruses. The human cytomegalovirus has been successfully treated with such a method, 92 but no known specific inhibitors of the MPXV kinases have been identified.…”

Section: Abl-family Tyrosine Kinase Inhibitormentioning

confidence: 99%

“…The F10L protein kinase (VPK2) is the main kinase encapsidated in virions and is required for viral replication 139 . F10L is required for early morphogenesis because it interacts with intracellular membranes and assists in the formation of immature virions 91 . Specific B1R and F10L inhibitors may prevent the replication of viruses.…”

Section: Monkeypox Therapeutic Drug Targets and Strategiesmentioning

confidence: 99%

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Monkeypox outbreak 2022: What we know so far and its potential drug targets and management strategies

Rabaan

Abas

Tallei

et al. 2022

Journal of Medical Virology

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Monkeypox is a rare zoonotic disease caused by infection with the monkeypox virus. The disease can result in flu‐like symptoms, fever, and a persistent rash. The disease is currently spreading throughout the world and prevention and treatment efforts are being intensified. Although there is no treatment that has been specifically approved for monkeypox virus infection, infected patients may benefit from using certain antiviral medications that are typically prescribed for the treatment of smallpox. The drugs are tecovirimat, brincidofovir, and cidofovir, all of which are currently in short supply due to the spread of the monkeypox virus. Resistance is also a concern, as widespread replication of the monkeypox virus can lead to mutations that produce monkeypox viruses that are resistant to the currently available treatments. This article discusses monkeypox disease, potential drug targets, and management strategies to overcome monkeypox disease. With the discovery of new drugs, it is hoped that the problem of insufficient drugs will be resolved, and it is not anticipated that drug resistance will become a major issue in the near future.

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Section: Abl-family Tyrosine Kinase Inhibitormentioning

confidence: 99%

Section: Monkeypox Therapeutic Drug Targets and Strategiesmentioning

confidence: 99%