The protein–protein interaction network and clinical significance of heat-shock proteins in esophageal squamous cell carcinoma

Sun, Huizhen; Cai, Xinyi; Zhou, Huicheng; Li, Xiaoqi; Du, Zhifeng; Zou, Hai-Ying; Wu, Jian‐Yi; Xie, Lei; Cheng, Yin-Wei; Xie, Wenming; Lü, Xiaomei; Xu, Li‐Yan; Chen, Long-Qi; Li, En‐Min; Wu, Bing‐Li

doi:10.1007/s00726-018-2569-8

Cited by 7 publications

(5 citation statements)

References 59 publications

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“…LCP2 , an inflammatory factor, was revealed as the potential prognostic factor in colorectal cancer and diffuse large B-cell lymphoma ( 29 , 30 ). In contrast to our results, the high expression levels of DHAJC5B and RNASE6 were reported to be associated with better survival in esophageal squamous cell carcinoma ( 31 , 32 ). In brief, the prognostic genes in our paper have not yet been thoroughly studied in previous literatures.…”

Section: Discussioncontrasting

confidence: 99%

Microenvironment-related prognostic genes in esophageal cancer

Zhou¹,

Wang²

2020

Transl Cancer Res TCR

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Background: Esophageal cancer is one of the most common malignant tumors. The role of tumor microenvironment in esophageal cancer is unclear. Methods:The gene expression profiles and clinical data of 158 patients with esophageal cancer were extracted from The Cancer Genome Atlas database. Immune scores and stromal scores were calculated based on ESTIMATE algorithm. According to different immune/stromal scores, differentially expressed genes (DEGs) were identified. The function enrichment, protein interactions of shared DEGs and their associations with overall survival were analyzed. Results:In regard to the association of the immune/stromal scores and disease stage, pathological type and overall survival, only the stromal scores among the different stages were significantly different (P=0.015). In the high immune and stromal score groups, 603 shared up-regulated genes were found. The related function and pathways included regulation of lymphocyte activation, cytokine binding and chemokine signaling pathway.Protein-protein interaction analysis showed that ITGAM had the most connections, followed by CXCL10 and CCR2. High expression of 11 genes, including MS4A7,

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Section: Discussioncontrasting

confidence: 99%

Microenvironment-related prognostic genes in esophageal cancer

Zhou¹,

Wang²

2020

Transl Cancer Res TCR

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“…It is reported that the expression of HSPs was higher in various tumors and closely associated with tumor progression [ 34 ]. HSPA1B could be considered as a promising target for prognostic prediction in esophageal cancer [ 35 ]. RUNX3, runt-related transcription factor 3, is a tumor suppressor gene involved in the TGF-β signaling pathway [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis of ceRNA network and tumor-infiltrating immune cells in esophageal cancer

Chen¹,

Zhou

Wang

et al. 2021

Bioscience Reports

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Background. Esophageal cancer (ESCA) is one of the most commonly diagnosed cancers in the world. Tumor immune microenvironment is closely related to tumor prognosis. This study aimed at analyzing the competing endogenous RNA (ceRNA) network and tumor-infiltrating immune cells in ESCA. Methods. The expression profiles of mRNAs, lncRNAs, and miRNAs were downloaded from the Cancer Genome Atlas database. A ceRNA network was established based on the differentially expressed RNAs by Cytoscape. CIBERSORT was applied to estimate the proportion of immune cells in ESCA. Prognosis-associated genes and immune cells were applied to establish prognostic models basing on Lasso and multivariate Cox analyses. The survival curves were constructed with Kaplan-Meier method. The predictive efficacy of the prognostic models was evaluated by the receiver operating characteristic (ROC) curves. Results. The differentially expressed mRNAs, lncRNAs, and miRNAs were identified. We constructed the ceRNA network including 23 lncRNAs, 19 miRNAs and 147 mRNAs. Five key molecules (HMGB3, HOXC8, HSPA1B, KLHL15, and RUNX3) were identified from the ceRNA network and five significant immune cells (Plasma cells, T cells follicular helper, Monocytes, Dendritic cells activated, and Neutrophils) were selected via CIBERSORT. The ROC curves based on key genes and significant immune cells all showed good sensitivity (AUC of 3-year survival: 0.739, AUC of 5-year survival: 0.899, AUC of 3-year survival: 0.824, AUC of 5-year survival: 0.876). There was certain correlation between five immune cells and five key molecules. Conclusion. This study provides an effective bioinformatics basis for exploring the potential biomarkers of ESCA and predicting its prognosis.

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“…These observations suggest that the chaperones may be secreted via extracellular vesicles, for instance. The cellular distribution of Hsps usually changes during the carcinogenic process [6,19,20,21]. Typically, they localize in the mitochondria (Hsp60) or in the cytoplasm of normal cells.…”

Section: Discussionmentioning

confidence: 99%

Immunomorphological Pattern of Molecular Chaperones in Normal and Pathological Thyroid Tissues and Circulating Exosomes: Potential Use in Clinics

Bavisotto

Cipolla

Graceffa

et al. 2019

IJMS

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The thyroid is a major component of the endocrine system and its pathology can cause serious diseases, e.g., papillary carcinoma (PC). However, the carcinogenic mechanisms are poorly understood and clinical useful biomarkers are scarce. Therefore, we determined if there are quantitative patterns of molecular chaperones in the tumor tissue and circulating exosomes that may be useful in diagnosis and provide clues on their participation in carcinogenesis. Hsp27, Hsp60, Hsp70, and Hsp90 were quantified by immunohistochemistry in PC, benign goiter (BG), and normal peritumoral tissue (PT). The same chaperones were assessed in plasma exosomes from PC and BG patients before and after ablative surgery, using Western blotting. Hsp27, Hsp60, and Hsp90 were increased in PC in comparison with PT and BG but no differences were found for Hsp70. Similarly, exosomal levels of Hsp27, Hsp60, and Hsp90 were higher in PC than in BG, and those in PC were higher before ablative surgery than after it. Hsp27, Hsp60, and Hsp90 show distinctive quantitative patterns in thyroid tissue and circulating exosomes in PC as compared with BG, suggesting some implication in the carcinogenesis of these chaperones and indicating their potential as biomarkers for clinical applications.

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The protein–protein interaction network and clinical significance of heat-shock proteins in esophageal squamous cell carcinoma

Cited by 7 publications

References 59 publications

Microenvironment-related prognostic genes in esophageal cancer

Microenvironment-related prognostic genes in esophageal cancer

Integrated analysis of ceRNA network and tumor-infiltrating immune cells in esophageal cancer

Immunomorphological Pattern of Molecular Chaperones in Normal and Pathological Thyroid Tissues and Circulating Exosomes: Potential Use in Clinics

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