The Protein Corona Leads to Deformation of Spherical Micelles

Cao, Cheng; Zhang, Lin; Kent, Ben; Wong, Sandy M.; Garvey, Christopher J.; Stenzel, Martina H.

doi:10.1002/anie.202101129

Cited by 20 publications

(26 citation statements)

References 51 publications

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“…These conclusions offer interesting guidelines for the design of specific sugar-based self-assembled amphiphiles in a wide range of fields, broadening their supramolecular design and, more specifically, mannose-based self-assembled amphiphiles. This addition process could be applied in biomedicine to design nanocarriers, where spherical micelles are required due to lower circulation times in the human body while cylindrical micelles are in demand due to their high aspect ratio and enhanced properties …”

Section: Discussionmentioning

confidence: 99%

Design and Self-Assembly of Sugar-Based Amphiphiles: Spherical to Cylindrical Micelles

et al. 2022

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Sugar-based amphiphiles are a relevant natural alternative to synthetic ones due to their biodegradable properties. An understanding of their structure–assembly relationship is needed to allow the concrete synthesis of suitable derivatives. Here, four different mannose-derivative surfactants are characterized by pendant drop, dynamic light scattering, small-angle X-ray scattering, cryotransmission electron microscopy, and molecular dynamics techniques in aqueous media. Measurements denote how the polysaccharide average degree of polymerization ( ) and the addition of a hydroxyl group to the hydrophobic tail, and thus the presence of a second hydrophilic moiety, affect their self-assembly. A variation in the of the amphiphile has no effect in the critical micelle concentration in contrast to a change in the hydrophobic molecular region. Moreover, high- amphiphiles self-assemble into spherical micelles irrespective of the hydroxyl group presence. Low- amphiphiles with only one hydrophilic moiety form cylindrical micelles, while the addition of a hydroxyl group to the tail leads to a spherical shape.

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Section: Discussionmentioning

confidence: 99%

Design and Self-Assembly of Sugar-Based Amphiphiles: Spherical to Cylindrical Micelles

et al. 2022

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“…Types of Block Copolymers for the Formation of Glycopolymer Micelles. The underpinning block copolymer is composed of a glycopolymer block in combination with a range of hydrophobic polymers such as poly(methyl methacrylate), [165][166][167]169,170 poly(butyl acrylate), 171 poly(ε-caprolactone), 139,140,145,191 various hydrophobic poly(amino acid)s, 147 poly(N-isopropylacrylamide), 129 a light-responsive azobenzene methacrylate monomer, 142 poly(trimethylene carbonate), poly-(γ-benzyl-L-glutamate), 134 or poly(6-cholesteryloxyhexyl methacrylate). 131 The resulting block copolymers were selfassembled to yield micelles, or other aggregates such as worms or polymersomes, 169 for the delivery of drugs such as DOX, curcumin, and paclitaxel (PTX) (Table 2).…”

Section: Uptake Can Be Assigned To the Presence Of Carbohydrates?mentioning

confidence: 99%

“…Keeping the nanoparticle size constant but varying the composition of the glycopolymer on the surface can reveal some insight. 165 Micelles of comparable sizes that are based on block copolymers with longer glycopolymer segments and high carbohydrate content usually perform better. 173,195 This was explained by better hydration of the shell and better glycopolymer mobility, providing better access to the receptor.…”

Section: Uptake Can Be Assigned To the Presence Of Carbohydrates?mentioning

confidence: 99%

“…This may also explain why denser glycopolymer brushes, as in micelles with higher aggregation number, perform worse than micelles where the core-forming glycopolymer block can move freely in a water-swollen shell. 165 This may be understood through enhanced access of mobile glycopolymers to the surface receptors, but the system is more complicated and will be discussed in greater detail later in this Perspective.…”

Section: Uptake Can Be Assigned To the Presence Of Carbohydrates?mentioning

confidence: 99%

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Glycopolymers for Drug Delivery: Opportunities and Challenges

Stenzel

2022

Macromolecules

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Glycopolymers are synthetic polymers with pendant sugars, which hold promise for a range of biomedical applications ranging from tissue engineering to sensing. The known specific interaction of glycopolymers with lectins has inspired researchers to use these polymers to deliver drugs to cells that overexpress lectin receptors. As a result, many glycopolymersbased on mannose, galactose, fructose, or other saccharides−have been used for the targeted delivery of drugs, ranging from traditional anticancer drugs to nucleic acid-derived therapeutics. For drug delivery purposes, glycopolymers are typically processed into nanoparticles that form a matrix to entrap the drug safely, such as micelles, polyplexes, polyion complex micelles, or other nanosized carriers. In vitro and in vivo studies have shown that drugs can indeed be delivered selectively to specific cells by leveraging the selective recognition of surface bound lectins. The key to the interaction between glycopolymers and lectins is the presence of strong intermolecular forces such as hydrogen bonding. The formation of strong hydrogen bonds can, however, also be one of the drawbacks of these materials. Glycopolymers tend to self-aggregate, they interact with drugs in unexpected ways, or they bind proteins in a nonspecific manner. Despite these challenges, nanoparticles based on glycopolymers might offer possibilities that cannot be replicated by other watersoluble polymers. They have already shown that they can effectively deliver drugs in vivo, though more preclinical studies are necessary to enable their broader clinical uptake. Further focus could be directed at an improved understanding of the interface between glycopolymers and the biological surrounding as a key to improve the targeting ability of these nanoparticles in vivo. In this Perspective, I will discuss the aspects to consider when preparing drug delivery carrier using glycopolymers. This will include the interaction of the glyconanoparticles with the drug and the resulting property changes, the types of glycopolymers suitable for drug delivery, the effect of the nanoparticle structure on the affinity to cell surface bound lectins or GLUT transporters and the promising in vivo results that show selective delivery.

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“…It also needs to be considered that these capsules may have adsorbed proteins that might have led to changes in size or shape. 54 One issue is that the solutions obtained by the preparation process are rather dilute and one research focus needs to be directed at making the solution more concentrated for in vivo studies. It is not possible to generate a nanocapsule solution at significantly higher drug concentrations as the increase of the drug concentration would result in low colloidal stability.…”

Section: Initial Biological Activity Studiesmentioning

confidence: 99%