The protein carboxymethyltransferase–dependent aspartate salvage pathway plays a crucial role in the intricate metabolic network of
Escherichia coli
Maureen Micaletto,
Sebastien Fleurier,
Sara Dion
et al.
Abstract:Protein carboxymethyltransferase (Pcm) is a highly evolutionarily conserved enzyme that initiates the conversion of abnormal isoaspartate to aspartate residues. While it is commonly believed that Pcm facilitates the repair of damaged proteins, a number of observations suggest that it may have another role in cell functioning. We investigated whether Pcm provides a means for
Escherichia coli
to recycle aspartate, which is essential for protein synthesis and other cellular processes. We s… Show more
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