The Protein-Binding Potential of C2H2 Zinc Finger Domains

Brayer, Kathryn J.; Kulshreshtha, Sanjeev; Segal, David J.

doi:10.1007/s12013-008-9007-6

Cited by 75 publications

(61 citation statements)

References 155 publications

(303 reference statements)

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“…The most characteristic structural feature for the transcription factor YY1 is the C-terminal C 2 H 2 -type zinc finger motifs (11). Although the main function of these motifs is to interact with nucleic acids, they have been also implicated in protein-protein interactions, including in some cases homo-dimerization (42)(43)(44). One example is Ikaros, a protein containing six C 2 H 2 -type zinc fingers, four of which are involved in DNA binding and the two C-terminal fingers are responsible for the assembly of a homodimer (45).…”

Section: Discussionmentioning

confidence: 99%

Structure of Yin Yang 1 Oligomers That Cooperate with RuvBL1-RuvBL2 ATPases

López-Perrote

Alatwi

Torreira

et al. 2014

Journal of Biological Chemistry

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Background: Oligomerization of transcription factor YY1 is not well understood. Results: YY1 assembles homo-oligomers that bind DNAs without the consensus sequence, whose structure is studied by electron microscopy. Conclusion: RuvBL1-RuvBL2 enhances YY1 binding to DNAs without the consensus sequence for the transcription factor. Significance: YY1-RuvBL1-RuvBL2 complexes could contribute to functions beyond transcription, and we find this occurs during homologous recombination.

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Section: Discussionmentioning

confidence: 99%

Structure of Yin Yang 1 Oligomers That Cooperate with RuvBL1-RuvBL2 ATPases

López-Perrote

Alatwi

Torreira

et al. 2014

Journal of Biological Chemistry

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“…Many of the interactions are between two KRAB-C2H2-ZF proteins (17 prey proteins), suggesting that KRAB may mediate oligomerization, directly or indirectly. It is also possible that some of the interactions are mediated by C2H2-ZF domains, which can interact with DNA, RNA, or protein (Brayer et al 2008;Burdach et al 2012). …”

Section: C2h2-zf Proteins Often Have Unique Ppi Profilesmentioning

confidence: 99%

Multiparameter functional diversity of human C2H2 zinc finger proteins

et al. 2016

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C2H2 zinc finger proteins represent the largest and most enigmatic class of human transcription factors. Their C2H2-ZF arrays are highly variable, indicating that most will have unique DNA binding motifs. However, most of the binding motifs have not been directly determined. In addition, little is known about whether or how these proteins regulate transcription. Most of the ∼700 human C2H2-ZF proteins also contain at least one KRAB, SCAN, BTB, or SET domain, suggesting that they may have common interacting partners and/or effector functions. Here, we report a multifaceted functional analysis of 131 human C2H2-ZF proteins, encompassing DNA binding sites, interacting proteins, and transcriptional response to genetic perturbation. We confirm the expected diversity in DNA binding motifs and genomic binding sites, and provide motif models for 78 previously uncharacterized C2H2-ZF proteins, most of which are unique. Surprisingly, the diversity in protein–protein interactions is nearly as high as diversity in DNA binding motifs: Most C2H2-ZF proteins interact with a unique spectrum of co-activators and co-repressors. Thus, multiparameter diversification likely underlies the evolutionary success of this large class of human proteins.

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“…Fezf2 encodes a zinc-finger protein that contains a putative repressor domain similar to that found in the Engrailed protein [35,36], and Ctip2 is known to repress transcription of the p57KIP2 locus [37]. Thus it seems plausible that Fezf2 and Ctip2 function as transcriptional repressors in the regulation of deep layer neuron fates.…”

Section: Fezf2 and Ctip2 Define The Fates Of Subcortical Projection Nmentioning

confidence: 99%

The determination of projection neuron identity in the developing cerebral cortex

Leone

Srinivasan

Chen

et al. 2008

Current Opinion in Neurobiology

334

316

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Here we review the mechanisms that determine projection neuron identity during cortical development. Pyramidal neurons in the mammalian cerebral cortex can be classified into two major classes: corticocortical projection neurons, which are concentrated in the upper layers of the cortex, and subcortical projection neurons, which are found in the deep layers. Early progenitor cells in the ventricular zone produce deep layer neurons that express transcription factors including Sox5, Fezf2, and Ctip2, which play important roles in the specification of subcortically projecting axons. Upper layer neurons are produced from progenitors in the subventricular zone, and the expression of Satb2 in these differentiating neurons is required for the formation of axonal projections that connect the two cerebral hemispheres. The Fezf2/Ctip2 and Satb2 pathways appear to be mutually repressive, thus ensuring that individual neurons adopt either a subcortical or callosal projection neuron identity at early times during development. The molecular mechanisms by which Satb2 regulates gene expression involves long-term epigenetic changes in chromatin configuration, which may enable cell fate decisions to be maintained during development.

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The Protein-Binding Potential of C2H2 Zinc Finger Domains

Cited by 75 publications

References 155 publications

Structure of Yin Yang 1 Oligomers That Cooperate with RuvBL1-RuvBL2 ATPases

Structure of Yin Yang 1 Oligomers That Cooperate with RuvBL1-RuvBL2 ATPases

Multiparameter functional diversity of human C2H2 zinc finger proteins

The determination of projection neuron identity in the developing cerebral cortex

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