The protective roles of citrus flavonoids, naringenin, and naringin on endothelial cell dysfunction in diseases

Adetunji, Joy A.; Fasae, Kehinde D.; Awe, Ayobami; Paimo, Oluwatomiwa K.; Adegoke, Ayodeji Mathias; Akintunde, J. K.; Sekhoacha, Mamello

doi:10.1016/j.heliyon.2023.e17166

Cited by 16 publications

(11 citation statements)

References 238 publications

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“…These properties encompass antioxidant activity, anti-inflammatory effects, and promising anticancer potential. 2,3 Furthermore, naringin has shown promise in providing cardiovascular and neuroprotection. 4 The binding of metal ions to bioactive compounds like naringin can introduce novel or enhanced biological functions to the ligands.…”

Section: Introductionmentioning

confidence: 99%

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Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium(iv)/naringin complex

Restrepo,

Huamani,

Velásquez Bravo

et al. 2024

New J. Chem.

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Section: Introductionmentioning

confidence: 99%

“…These properties encompass antioxidant activity, anti-inflammatory effects, and promising anti-cancer potential. 2,3 Furthermore, naringin has shown promise in providing cardiovascular and neuroprotection. 4…”

Section: Introductionmentioning

confidence: 99%

Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium(iv)/naringin complex

Restrepo,

Huamani,

Velásquez Bravo

et al. 2024

New J. Chem.

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“…Dietary polyphenols exhibit a wide range of biological activities, such as antiatherogenic, antioxidant, anti-mutagenic, anti-inflammatory and antimicrobial properties [ 4 , 5 ]. Among phenolic derivatives, major significance is given to flavonoids, due to their antioxidant, anti-inflammatory, antibacterial, antiviral and anti-allergic properties in various pathologies [ 6 , 7 ]. Flavonoids mainly act as antioxidants, inhibiting free radical-induced cytotoxicity and lipid peroxidation and as such they can protect against chronic diseases such as atherosclerosis, cancer and others.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the Sideritis scardica Extract SidTea+TM and Its Effect on Physiological Profile, Metabolic Health and Redox Biomarkers in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study

Papanikolaou,

Kouloridas,

Rosvoglou

et al. 2024

Molecules

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This study aimed to characterize a Sideritis scardica extract (SidTea+TM) and investigate its effect on the physiological profile, metabolic health and redox status in healthy individuals. The chemical profile and antioxidant potential of the SidTea+TM extract were evaluated by UPLC-HRMS analysis and in vitro cell-free methods. Twenty-eight healthy adults participated in this randomized, double-blind, placebo-controlled study. Participants consumed 1500 mg/day of SidTea+TM or a placebo for 4 weeks. At baseline and post-supplementation, participants were assessed for their anthropometric and physiological profile and provided a resting blood sample. SidTea+TM decreased (p < 0.05) systolic blood pressure (−10.8 mmHg), mean arterial pressure (−4.5 mmHg), resting heart rate (−3.1 bpm) and handgrip strength of the non-dominant limb (−0.8 kg) whereas the placebo decreased (p < 0.05) handgrip strength of the dominant (−5.8 kg) and non-dominant (−3.2 kg) limb. SidTea+TM also resulted in an increase (p < 0.05) in estimated VO2max (+1.1 mL/kg/min) and a reduction (p < 0.05) in γ-GT and SGPT enzymatic activity in serum (−3.7 and −3.3 U/L, respectively). Finally, SidTea+TM increased (p < 0.001) total antioxidant capacity and decreased (p < 0.05) lipid peroxidation levels in plasma. These results indicate that SidTea+TM is a potent and safe to use antioxidant that can elicit positive changes in indices of blood pressure, cardiorespiratory capacity, liver metabolism, and redox status in healthy adults over a 4-week supplementation period.

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“…Diets rich in fruit and vegetables have been proved to have health benefits by reducing the risk of suffering from degenerative diseases [1,2]. In particular, the health beneficial effects of citrus fruits have been attributed mainly to ascorbic acid and flavonoids, such as naringenin and naringin [3,4]. In recent times, changes in lifestyles have led to increased consumer demand for ready-to-eat fruit products to satisfy their requirements for balanced and healthy diets [5].…”

Section: Introductionmentioning

confidence: 99%

A New Ready-to-Eat Product Based on Enzymatically Peeled ‘Hernandina’ Clementine Segments and Citrus Syrup

Díaz-Mula,

López,

Serrano

et al. 2023

Foods

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Ready-to-eat fresh fruit have an increasing presence in international markets due to their convenience and health benefits. However, these products are highly perishable and efficient technologies to increase their shelf life are needed. In the present research, different citrus fruit species and cultivars from organic farming were assessed to obtain enzymatically peeled citrus segments. The best results in terms of segment quality were observed for ‘Hernandina’ clementine, which was chosen to make a new ready-to-eat product based on peeled citrus segments that were packaged in glass jars with a light syrup made of citrus juice and organic sugar cane. Different citrus juice mixtures were assayed and the most appreciated syrup, based on the sensory scores given by panellists, was that containing 50–50 (v/v) of ‘Fino’ lemon and ‘Hernandina’ clementine juices. In addition, different pasteurization treatments were assessed for their effects on conserving the safety, nutritional quality and sensory properties of the product during cold storage. The results show that pasteurization treatment at 50 °C for 45 min was sufficient to prevent microbial contamination with mesophilic and psychrophilic aerobic bacteria or yeast and mould and to maintain sensory properties until five weeks of storage at 4 °C. In addition, only a 10% reduction in vitamin C concentrations was observed in fresh-segments or syrup until the end of the storage period, showing that a high bioactive compound content and health benefits were conserved in the new ready-to-eat product after pasteurization and prolonged cold storage.

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The protective roles of citrus flavonoids, naringenin, and naringin on endothelial cell dysfunction in diseases

Cited by 16 publications

References 238 publications

Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium(iv)/naringin complex

Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium(iv)/naringin complex

Characterization of the Sideritis scardica Extract SidTea+TM and Its Effect on Physiological Profile, Metabolic Health and Redox Biomarkers in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study

A New Ready-to-Eat Product Based on Enzymatically Peeled ‘Hernandina’ Clementine Segments and Citrus Syrup

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