“…Lunasin belongs to the 2S soy albumin protein with 43 amino acid residues whose biological activity is attributed to the presence of a cell adhesion motif composed of arginine-glycine-aspartic acid residues and a carboxylic acid tail composed of 8 aspartic acid residues (Galvez & Lumen, 1999;Lule, Garg, Pophely, Hitesh & Tomar, 2015). Lunasin possessed different potential biological properties including anti-cancer (Shidal, Al-Rayyan, Yaddanapudi & Davis, 2016;Jiang, Pan, Cheng, Li, Liu & Li, 2016;Hsieh, Hernández-Ledesma, Jeong, Park, & de Lumen, 2010) anti-inflammatory (Dia, Wang, Oh, de Lumen & de Mejia, 2009;Cam & de Mejia, 2012;Cruz-Huerta et al, 2015;Hernández-Ledesma, Hsieh,& de Lumen, 2009) and immunomodulating properties (Yang et al, 2015;Tung et al, 2014). One potential issue on the use of lunasin as a chemopreventive and chemotherapeutic agents is its susceptibility to digestion as previous studies have shown that up to 97% of the lunasin is digested leading to low nanomolar concentrations found in human plasma after ingesting 50 g of soy protein (Dia, Torres, de Lumen, Erdman & de Mejia, 2009).…”