“…DAMPs promote a sterile inflammatory response in the lung by binding to pattern recognition receptors (PRRs) constitutively expressed in the pulmonary endothelium. 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 We recently showed that DAMPs generated from injured renal tubular epithelial cells (RTECs) cause upregulation of PRRs, increase production of inflammatory mediators, and activate pro‐inflammatory signaling pathways in healthy renal tubular epithelium. 16 DAMPs, which contribute to injurious inflammation after renal ischemia–reperfusion injury (IRI), are likely released into the circulation where they encounter PRRs constitutively expressed in pulmonary endothelium.…”