The Protective Role of Helminths in Autoimmunity

Bashi, Tomer; Konikoff, Tom; Blank, Miri; Shoenfeld, Yehuda

doi:10.1016/b978-0-444-63269-2.00012-x

Cited by 1 publication

(1 citation statement)

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“…SLE is far more common in people of African descent outside Africa than in African natives, particularly in areas where malaria is highly prevalent, 21,22 suggesting that genes that confer high susceptibility to SLE can protect against malaria. Therefore, in the absence of continued exposure to Plasmodium , these genes can generate exacerbated immune response, as seen in SLE.…”

Section: Parasitesmentioning

confidence: 99%

The role of infections in neuropsychiatric lupus

Ribeiro

Signorelli

2017

Lupus

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Opportunistic infections can cause manifestations that resemble neuropsychiatric systemic lupus erythematosus and they can also trigger lupus flares. Therefore, central nervous system infections as differential diagnosis in neuropsychiatric systemic lupus erythematosus may be difficult, leading to delayed diagnosis and specific treatment. Central nervous system infection in systemic lupus erythematosus is not common but, if left misdiagnosed and not treated promptly, can be fatal. Complementary diagnosis tests are generally non-specific and disappointing. Caution with immunosuppressive drug treatment should be emphasized while an opportunistic infection cannot be ruled out. In this review, we discuss the various types of central nervous system infections reported in systemic lupus erythematosus patients, highlighting the importance of their early recognition in order to improve morbidity and mortality. Prevention with vaccination is a recommended approach.

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Section: Parasitesmentioning

confidence: 99%