The protective role of hawthorn fruit extract against high salt-induced hypertension in Dahl salt-sensitive rats: impact on oxidative stress and metabolic patterns

Zheng, Xiaodong; Li, Xiaoxue; Chen, Meng; Yang, Pengfei; Zhao, Xiaomin; Zeng, Li; Ouyang, Yanan; Yang, Zhe; Tian, Zhongmin

doi:10.1039/c8fo01818a

Cited by 33 publications

(20 citation statements)

References 42 publications

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“…One of the main possible mechanisms for behavioral changes caused by salt consumption is related to the oxidative stress ( Santisteban and Iadecola, 2018 ; He et al, 2020 ). Evidence indicates that a high-salt diet can reduce nitric oxide (NO) production ( Dong et al, 2011 ; Kouyoumdzian et al, 2016 ; Zheng et al, 2019 ), suppress the activity of antioxidant enzymes ( Kitiyakara et al, 2003 ; Huang et al, 2017 ), and increase the production of nitrogen and oxygen-free radicals ( Kitiyakara et al, 2003 ; Huang et al, 2017 ; Zheng et al, 2019 ). Also, it is highlighted that a high-salt diet causes oxidative stress in the hippocampus, hypothalamus, and cerebellum, important brain regions for behavior and cognition ( Bai et al, 2017 ; Ge et al, 2017 ; Stocher et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

High-Salt Diet in the Pre- and Postweaning Periods Leads to Amygdala Oxidative Stress and Changes in Locomotion and Anxiety-Like Behaviors of Male Wistar Rats

Leal

Silva

Rocha-Gomes

et al. 2022

Front. Behav. Neurosci.

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High-salt (HS) diets have recently been linked to oxidative stress in the brain, a fact that may be a precursor to behavioral changes, such as those involving anxiety-like behavior. However, to the best of our knowledge, no study has evaluated the amygdala redox status after consuming a HS diet in the pre- or postweaning periods. This study aimed to evaluate the amygdala redox status and anxiety-like behaviors in adulthood, after inclusion of HS diet in two periods: preconception, gestation, and lactation (preweaning); and only after weaning (postweaning). Initially, 18 females and 9 male Wistar rats received a standard (n = 9 females and 4 males) or a HS diet (n = 9 females and 5 males) for 120 days. After mating, females continued to receive the aforementioned diets during gestation and lactation. Weaning occurred at 21-day-old Wistar rats and the male offspring were subdivided: control-control (C-C)—offspring of standard diet fed dams who received a standard diet after weaning (n = 9–11), control-HS (C-HS)—offspring of standard diet fed dams who received a HS diet after weaning (n = 9–11), HS-C—offspring of HS diet fed dams who received a standard diet after weaning (n = 9–11), and HS-HS—offspring of HS diet fed dams who received a HS diet after weaning (n = 9–11). At adulthood, the male offspring performed the elevated plus maze and open field tests. At 152-day-old Wistar rats, the offspring were euthanized and the amygdala was removed for redox state analysis. The HS-HS group showed higher locomotion and rearing frequency in the open field test. These results indicate that this group developed hyperactivity. The C-HS group had a higher ratio of entries and time spent in the open arms of the elevated plus maze test in addition to a higher head-dipping frequency. These results suggest less anxiety-like behaviors. In the analysis of the redox state, less activity of antioxidant enzymes and higher levels of the thiobarbituric acid reactive substances (TBARS) in the amygdala were shown in the amygdala of animals that received a high-salt diet regardless of the period (pre- or postweaning). In conclusion, the high-salt diet promoted hyperactivity when administered in the pre- and postweaning periods. In animals that received only in the postweaning period, the addition of salt induced a reduction in anxiety-like behaviors. Also, regardless of the period, salt provided amygdala oxidative stress, which may be linked to the observed behaviors.

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Section: Introductionmentioning

confidence: 99%

High-Salt Diet in the Pre- and Postweaning Periods Leads to Amygdala Oxidative Stress and Changes in Locomotion and Anxiety-Like Behaviors of Male Wistar Rats

Leal

Silva

Rocha-Gomes

et al. 2022

Front. Behav. Neurosci.

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“…The pectin oligosaccharides of the C. pinnatifida fruit also reduced the aberrant oxidative state in a mouse model of experimental hyperlipidemia, as indicated by reduced serum synthesis and accumulation of malondialdehyde and increased SOD levels (Li et al, 2010). Metabolomic results showed that seedless hawthorn fruit extracts increased the levels of 11 different metabolites related to oxidative responses, as well as the concentration of NO and the activity of NO synthase, which are known factors that prevent against oxidative impairments (Zheng et al, 2019). The mechanism may involve the nuclear factor erythroid 2-related factor (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway, major sentinels, and effectors in response to the oxidative status (Yoo et al, 2016).…”

Section: Anti-oxidative Activitymentioning

confidence: 97%

Roles and Mechanisms of Hawthorn and Its Extracts on Atherosclerosis: A Review

Liu

Xing

et al. 2020

Front. Pharmacol.

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Cardiovascular disease (CVD), especially atherosclerosis, is a leading cause of morbidity and mortality globally; it causes a considerable burden on families and caregivers and results in significant financial costs being incurred. Hawthorn has an extensive history of medical use in many countries. In China, the use of hawthorn for the treatment of CVD dates to 659 AD. In addition, according to the theory of traditional Chinese medicine, it acts on tonifying the spleen to promote digestion and activate blood circulation to dissipate blood stasis. This review revealed that the hawthorn extracts possess serum lipid-lowering, anti-oxidative, and cardiovascular protective properties, thus gaining popularity, especially for its antiatherosclerotic effects. We summarize the four principal mechanisms, including blood lipidlowering, anti-oxidative, anti-inflammatory, and vascular endothelial protection, thus providing a theoretical basis for further utilization of hawthorn.

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“…In addition, functional association networks of DEPs were constructed using STRING (http://string-db.org/), and ClueGo was used to perform a visualization analysis of the protein-protein interaction (PPI) [21]. Pheatmap (version 1.0.12), ggplot2 (version 3.0.0) and WGCNA (version 1.63) packages of R software (version 3.5.0) [22,23] were used for visualization of heatmaps, bubble diagrams and WGCNA analysis, respectively.…”

Section: Bioinformatics Analysismentioning

confidence: 99%

Novel insights into plasma biomarker candidates in patients with chronic mountain sickness based on proteomics

Zhang

Yang

et al. 2021

Bioscience Reports

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Chronic mountain sickness (CMS) is a progressive incapacitating syndrome induced by lifelong exposure to hypoxia. In the present study, proteomic analysis was used to identify the differentially expressed proteins (DEPs) and then evaluate the potential plasma biomarkers between CMS and non-CMS groups. A total of 145 DEPs were detected in CMS Han Chinese people who live in the plateau (CMS-HPu), among which 89 were significantly up-regulated and 56 were significantly down-regulated. GO enrichment analysis showed that various biological processes were enriched, including the hydrogen peroxide metabolic/catabolic process, reactive oxygen species (ROS) metabolic, and acute inflammatory response. Protein–protein interaction analysis showed that antioxidant activity, the hydrogen peroxide catabolic process and peroxidase activity were primarily mapped in interaction proteins. Nine modules showed significantly clustering based on WGCNA analysis, with two being the most significant, and GO analysis showed that proteins of both modules were primarily enriched in oxidative stress-related biological processes. Four DEPs increased in CMS patients were evaluated as the candidate biomarkers, and three showed significant AUC: hemoglobin β chain (HB-β), thioredoxin-1 (TRX1), and phosphoglycerate kinase 1 (PGK1). The present study provides insights into the pathogenesis of CMS and further evaluates the potentially biomarkers for its prevention and treatment of it.

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The protective role of hawthorn fruit extract against high salt-induced hypertension in Dahl salt-sensitive rats: impact on oxidative stress and metabolic patterns

Abstract: Hawthorn fruit extract can significantly attenuate high salt-induced hypertension in Dahl salt-sensitive rats.

Cited by 33 publications

References 42 publications

High-Salt Diet in the Pre- and Postweaning Periods Leads to Amygdala Oxidative Stress and Changes in Locomotion and Anxiety-Like Behaviors of Male Wistar Rats

High-Salt Diet in the Pre- and Postweaning Periods Leads to Amygdala Oxidative Stress and Changes in Locomotion and Anxiety-Like Behaviors of Male Wistar Rats

Roles and Mechanisms of Hawthorn and Its Extracts on Atherosclerosis: A Review

Novel insights into plasma biomarker candidates in patients with chronic mountain sickness based on proteomics

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