The protective role of Chitooligosaccharides against chronic ulcerative colitis induced by dextran sulfate sodium in mice

Guo, Jie; Liao, Mengfan; Zhu, Yujie; Hu, Xianmin; Wang, Jun

doi:10.1016/j.jff.2021.104809

Cited by 9 publications

(5 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Activation of NF-κB signaling pathway induces secretion of TNF-α and IL-1β and exacerbates inflammation ( 50 ). COS was reported to reduce intestinal inflammation by inhibiting the NF-κB signaling pathway ( 33 , 51 ). In a study of Salmonella -infected chickens, C. butyricum downregulated levels of proinflammatory cytokines (IFN-γ, IL-1β, IL-8, TNF-α) and reduced inflammatory reactions in intestinal epithelial cells by inhibiting the NF-κB signaling pathway ( 52 ).…”

Section: Discussionmentioning

confidence: 99%

Clostridium butyricum and Chitooligosaccharides in Synbiotic Combination Ameliorate Symptoms in a DSS-Induced Ulcerative Colitis Mouse Model by Modulating Gut Microbiota and Enhancing Intestinal Barrier Function

Huang

Zhang

et al. 2023

Microbiol Spectr

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Clostridium butyricum and Chitooligosaccharides in Synbiotic Combination Ameliorate Symptoms in a DSS-Induced Ulcerative Colitis Mouse Model by Modulating Gut Microbiota and Enhancing Intestinal Barrier Function

Huang

Zhang

et al. 2023

Microbiol Spectr

View full text Add to dashboard Cite

show abstract

“…COS has smaller molecular weight (MW), lower degree of polymerization (DP), and good water solubility which chitosan does not possess [ 13 , 14 , 15 ]. Similar to other natural carbohydrate [ 16 , 17 ], COS has been shown to have good immunogenicity and anti-inflammatory activity in vitro [ 18 , 19 , 20 ] and in vivo [ 21 , 22 , 23 ], and is expected to be a good natural anti-inflammatory drug to prevent and treat endotoxemia. The anti-inflammatory activity of COS is related to its structural parameters, including MW, DP and degree of acetylation (DA) etc.…”

Section: Introductionmentioning

confidence: 99%

The Effect of N-Acetylation on the Anti-Inflammatory Activity of Chitooligosaccharides and Its Potential for Relieving Endotoxemia

Hao

et al. 2022

IJMS

View full text Add to dashboard Cite

Endotoxemia is mainly caused by a massive burst of inflammatory cytokines as a result of lipopolysaccharide (LPS) invasion. Chitooligosaccharides (COS) is expected to be a potential drug for relieving endotoxemia due to its anti-inflammatory properties. However, the structural parameters of COS are often ambiguous, and the effect of degree of acetylation (DA) of COS on its anti-inflammatory remains unknown. In this study, four COSs with different DAs (0%, 12%, 50% and 85%) and the same oligomers distribution were successfully obtained. Their structures were confirmed by 1H NMR and MS analysis. Then, the effect of DA on the anti-inflammatory activity and relieving endotoxemia potential of COS was researched. The results revealed that COS with a DA of 12% had better anti-inflammatory activity than COSs with other DAs, mainly in inhibiting LPS-induced inflammatory cytokines burst, down-regulating its mRNA expression and reducing phosphorylation of IκBα. Furthermore, this COS showed an obviously protective effect on endotoxemia mice, such as inhibiting the increase in inflammatory cytokines and transaminases, alleviating the injury of liver and intestinal tissue. This study explored the effect of DA on the anti-inflammatory activity of COS for the first time and lays the foundation for the development of COS as an anti-inflammatory drug against endotoxemia.

show abstract

“…For example, COS has been shown to reduce liver injury due to excessive inflammation or bursts of reactive oxygen species [ 10 , 11 , 12 ]. Furthermore, COS can alleviate enteritis damage in mice or turbot [ 13 , 14 ]. There is also some research suggesting that COS could modulate macrophage polarization in mice or blunt-snout bream [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Pleiotropic Modulation of Chitooligosaccharides on Inflammatory Signaling in LPS-Induced Macrophages

Hao

Liu

et al. 2023

Polymers

View full text Add to dashboard Cite

Chitooligosaccharide (COS) is a green and non-toxic cationic carbohydrate that has attracted wide attention in recent years due to its anti-inflammatory activity. However, the anti-inflammatory mechanism of COS remains unclear. In this study, RNA-seq was used to investigate the integrated response of COS to LPS-induced damage in macrophages. The results showed that the experimental group with COS had 2570 genes with significant differences compared to the model group, and that these genes were more enriched in inflammatory and immune pathways. The KEGG results showed that COS induces the pleiotropic modulation of classical inflammatory pathways, such as the Toll-like receptor signaling pathway, NF-κB, MAPK, etc. Based on the RNA-seq data and the RT-qPCR, as well as the WB validation, COS can significantly upregulate the expression of membrane receptors, such as Tlr4, Tlr5, and MR, and significantly inhibits the phosphorylation of several important proteins, such as IκB and JNK. Overall, this study offers deep insights into the anti-inflammatory mechanism and lays the foundation for the early application of COS as an anti-inflammatory drug.

show abstract

The protective role of Chitooligosaccharides against chronic ulcerative colitis induced by dextran sulfate sodium in mice

Cited by 9 publications

References 51 publications

Clostridium butyricum and Chitooligosaccharides in Synbiotic Combination Ameliorate Symptoms in a DSS-Induced Ulcerative Colitis Mouse Model by Modulating Gut Microbiota and Enhancing Intestinal Barrier Function

Clostridium butyricum and Chitooligosaccharides in Synbiotic Combination Ameliorate Symptoms in a DSS-Induced Ulcerative Colitis Mouse Model by Modulating Gut Microbiota and Enhancing Intestinal Barrier Function

The Effect of N-Acetylation on the Anti-Inflammatory Activity of Chitooligosaccharides and Its Potential for Relieving Endotoxemia

Pleiotropic Modulation of Chitooligosaccharides on Inflammatory Signaling in LPS-Induced Macrophages

Contact Info

Product

Resources

About