The protective mechanisms underlying Ginsenoside Rg1 effects on rat sciatic nerve injury

Huo, Dong-Sheng; Sun, Jian-Fang; Cai, Zhen; Yan, Xu-Sheng; Wang, He; Jia, Jianxin; Yang, Zhenhua

doi:10.1080/15287394.2019.1684028

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…In addition to blocking apoptosis, this protein modulates many other signaling processes, including the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway and inflammatory responses. In rat peripheral nerve injury, the upregulated expression of Xiap may decrease neuronal cell apoptosis, resulting in subsequent peripheral nerve regeneration [ 46 , 47 ]. Braf (alternately referred to as v-raf murine sarcoma viral oncogene homolog B1) is a proto-oncogene involved in the mitogen-activated protein kinase (MAPK) pathway.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Neuropathology after Nerve Release in Chronic Constriction Injury of Rat Sciatic Nerve

Chen

Lin

et al. 2021

IJMS

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Peripheral compressive neuropathy causes significant neuropathic pain, muscle weakness and prolong neuroinflammation. Surgical decompression remains the gold standard of treatment but the outcome is suboptimal with a high recurrence rate. From mechanical compression to chemical propagation of the local inflammatory signals, little is known about the distinct neuropathologic patterns and the genetic signatures after nerve decompression. In this study, controllable mechanical constriction forces over rat sciatic nerve induces irreversible sensorimotor dysfunction with sustained local neuroinflammation, even 4 weeks after nerve release. Significant gene upregulations are found in the dorsal root ganglia, regarding inflammatory, proapoptotic and neuropathic pain signals. Genetic profiling of neuroinflammation at the local injured nerve reveals persistent upregulation of multiple genes involving oxysterol metabolism, neuronal apoptosis, and proliferation after nerve release. Further validation of the independent roles of each signal pathway will contribute to molecular therapies for compressive neuropathy in the future.

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Section: Discussionmentioning

confidence: 99%

Investigation of Neuropathology after Nerve Release in Chronic Constriction Injury of Rat Sciatic Nerve

Chen

Lin

et al. 2021

IJMS

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“…Researchers (Ye et al, 2016(Ye et al, , 2019Liu X. et al, 2018;Huo et al, 2019;Zhang et al, 2022) have confirmed that Rb1 and Rg1 significantly decrease the levels of ROS, RNS, and MDA after SCI to reduce oxidative stress in spinal cord tissues. In contrast, Ye and Huo found that the quantity of survivin protein and X-linked inhibitor of apoptosis protein (XIAP), around injured sites, increased in response to oxidative stress.…”

Section: Anti-oxidative Stressmentioning

confidence: 96%

Mechanisms of ginsenosides exert neuroprotective effects on spinal cord injury: A promising traditional Chinese medicine

Zhang

Wang

et al. 2022

Front. Neurosci.

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Spinal cord injury (SCI) is a devastating disorder of the central nervous system (CNS). It is mainly caused by trauma and reduces the quality of life of the affected individual. Ginsenosides are safe and effective traditional Chinese medicines (TCMs), and their efficacy against SCI is being increasingly researched in many countries, especially in China and Korea. This systematic review evaluated the neuroprotective effects of ginsenosides in SCI and elucidated their properties.MethodsAll experimental information and summaries used in this review were acquired from peer-reviewed articles in the relevant fields. The PubMed, Web of Science, Google Scholar, and China National Knowledge Infrastructure databases were searched for relevant articles. Information on the manual classification and selection of ginsenosides that protect against SCI is included in this review.ResultsA literature survey yielded studies reporting several properties of ginsenosides, including anti-inflammation, anti-apoptosis, anti-oxidative stress, and inhibition of glial scar formation.ConclusionIn this review, we discuss the mechanisms of action of different ginsenosides that exert neuroprotective effects in SCI. These results suggest that after further verification in the future, ginsenosides may be used as adjunctive therapy to promote neurological recovery.

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“…These beneficial effects are attributed to the anti‐oxidant properties of GsRg1 (Zhao et al., 2014). Recently, it is found that GsRg1 significantly decreased malondialdehyde (MDA) levels, elevated the activities of SOD and GSH, diminished protein expression of XIAP accompanied by elevated expression of caspase‐3 in the spinal cord, suggesting that the protective effects of GsRg1 in sciatic nerve injury may be associated with reduced oxidative stress involving anti‐apoptotic pathways (Huo et al., 2019). It stimulates nerve regeneration which depends on ERK1/2 and JNK1/2 signaling pathways (Wang et al., 2015).…”

Section: Classification Of Natural Compoundsmentioning

confidence: 99%

Dietary biomolecules as promising regenerative agents for peripheral nerve injury: An emerging nutraceutical‐based therapeutic approach

et al. 2021

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Peripheral nerve damage is a debilitating condition that can result in partial or complete functional loss as a result of axonal degeneration, as well as lifelong dependence. Many therapies have been imbued with a plethora of positive features while posing little risks. It is worth noting that these biomolecules work by activating several intrinsic pathways that are known to be important in peripheral nerve regeneration. Although the underlying mechanism is used for accurate and speedy functional recovery, none of them are without side effects. As a result, it is believed that effective therapy is currently lacking. The dietary biomolecules‐based intervention, among other ways, is appealing, safe, and effective. Upregulation of transcription factors, neurotrophic factors, and growth factors such as NGF, GDNF, BDNF, and CTNF may occur as a result of these substances' dietary intake. Upregulation of the signaling pathways ERK, JNK, p38, and PKA has also been seen, which aids in axonal regeneration. Although several mechanistic approaches to understanding their involvement have been suggested, more work is needed to reveal the amazing properties of these biomolecules. We have discussed in this article that how different dietary biomolecules can help with functional recovery and regeneration after an injury. Practical applications Based on the information known to date, we may conclude that treatment techniques for peripheral nerve injury have downsides, such as complications, donor shortages, adverse effects, unaffordability, and a lack of precision in efficacy. These difficulties cast doubt on their efficacy and raise severe concerns about the prescription. In this situation, the need for safe and effective therapeutic techniques is unavoidable, and dietary biomolecules appear to be a safe, cost‐efficient, and effective way to promote nerve regeneration following an injury. The information on these biomolecules has been summarized here. Upregulation of transcription factors, neurotrophic factors, and growth factors, such as NGF, GDNF, BDNF, and CTNF, as well as the ERK, JNK, p38, and PKA, signaling pathways, may stimulate axonal regeneration.

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The protective mechanisms underlying Ginsenoside Rg1 effects on rat sciatic nerve injury

Cited by 7 publications

References 26 publications

Investigation of Neuropathology after Nerve Release in Chronic Constriction Injury of Rat Sciatic Nerve

Investigation of Neuropathology after Nerve Release in Chronic Constriction Injury of Rat Sciatic Nerve

Mechanisms of ginsenosides exert neuroprotective effects on spinal cord injury: A promising traditional Chinese medicine

Dietary biomolecules as promising regenerative agents for peripheral nerve injury: An emerging nutraceutical‐based therapeutic approach

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