The Protective Effects of Volatile Anesthestics Against the Bronchoconstriction Induced by an Allergic Reaction in Sensitized Rabbit Pups

Lele, Enikö; Peták, Ferenc; Carnesecchi, Stéphanie; Virág, Katalin; Argiroffo, Constance Barazzone; Habre, Walid

doi:10.1213/ane.0b013e31828e5ccf

Cited by 14 publications

(8 citation statements)

References 37 publications

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“…There were no differences in basal airway or respiratory tissue mechanical parameters between the different groups. These findings are in agreement with previous reports of the lack of effect of OVA sensitization and atropine on baseline respiratory mechanics . However, in the present study there was an increase in static lung volume in atropine‐treated rats.…”

Section: Discussionsupporting

confidence: 94%

Blockade of the cholinergic system during sensitization enhances lung responsiveness to allergen in rats

Malaspinas

Peták

Baudat

et al. 2018

Clin Exp Pharma Physio

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Although acute prophylactic administration of atropine modulates airway responsiveness, the role of the parasympathetic nervous system in the pathogenesis of sensitization and in antigen-induced bronchoconstriction remains unclear. The aim of the present study is to determine whether blocking muscarinic receptors during chronic allergen exposure modulates lung responsiveness to the specific allergen. Forty rats were randomly assigned to one of the following five treatment groups: sensitization with saline vehicle, intraperitoneal injection of ovalbumin (1 mg) with or without atropine treatment (10 mg/kg per day) and repeated ovalbumin aerosol (1.25 mg/mL for 20 minutes) either alone or combined with atropine. Lung responsiveness to methacholine (4-16 μg/kg per minute) and intravenous ovalbumin (2 mg) was established before and 21 days after treatment with forced oscillations following bilateral vagotomy. Lung cellularity was determined by analysis of bronchoalveolar lavage fluid (BALF). A lung inflammatory response in all sensitized animals was defined as an increase in the number of inflammatory cells in the BALF. Baseline respiratory mechanics and methacholine responsiveness on Days 0 and 21 were comparable in all groups. However, increases in airway resistance following intravenous allergen challenge were significantly exacerbated in rats that received atropine. Inhibition of the cholinergic nervous system during allergic sensitization potentiates bronchoconstriction following exposure to the specific allergen. These findings highlight the role of the cholinergic neuronal pathway in airway sensitization to a specific allergen.

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Section: Discussionsupporting

confidence: 94%

Blockade of the cholinergic system during sensitization enhances lung responsiveness to allergen in rats

Malaspinas

Peták

Baudat

et al. 2018

Clin Exp Pharma Physio

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“…Respiratory system mechanical parameters obtained in BL conditions or following induction of lung injury exhibited excellent agreement with previous data from the same species with similar weight range [ 14 – 16 , 28 ]. Furthermore, the time course of the respiratory mechanical parameters over 5 h of ventilation in the control groups is in accordance with that observed previously in an experimental model using adult rabbits [ 18 ].…”

Section: Discussionsupporting

confidence: 84%

Physiologically variable ventilation reduces regional lung inflammation in a pediatric model of acute respiratory distress syndrome

et al. 2020

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Background Benefits of variable mechanical ventilation based on the physiological breathing pattern have been observed both in healthy and injured lungs. These benefits have not been characterized in pediatric models and the effect of this ventilation mode on regional distribution of lung inflammation also remains controversial. Here, we compare structural, molecular and functional outcomes reflecting regional inflammation between PVV and conventional pressure-controlled ventilation (PCV) in a pediatric model of healthy lungs and acute respiratory distress syndrome (ARDS). Methods New-Zealand White rabbit pups (n = 36, 670 ± 20 g [half-width 95% confidence interval]), with healthy lungs or after induction of ARDS, were randomized to five hours of mechanical ventilation with PCV or PVV. Regional lung aeration, inflammation and perfusion were assessed using x-ray computed tomography, positron-emission tomography and single-photon emission computed tomography, respectively. Ventilation parameters, blood gases and respiratory tissue elastance were recorded hourly. Results Mechanical ventilation worsened respiratory elastance in healthy and ARDS animals ventilated with PCV (11 ± 8%, 6 ± 3%, p < 0.04), however, this trend was improved by PVV (1 ± 4%, − 6 ± 2%). Animals receiving PVV presented reduced inflammation as assessed by lung normalized [18F]fluorodeoxyglucose uptake in healthy (1.49 ± 0.62 standardized uptake value, SUV) and ARDS animals (1.86 ± 0.47 SUV) compared to PCV (2.33 ± 0.775 and 2.28 ± 0.3 SUV, respectively, p < 0.05), particularly in the well and poorly aerated lung zones. No benefit of PVV could be detected on regional blood perfusion or blood gas parameters. Conclusions Variable ventilation based on a physiological respiratory pattern, compared to conventional pressure-controlled ventilation, reduced global and regional inflammation in both healthy and injured lungs of juvenile rabbits.

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“…Moreover, indirect mechanisms associated with prevention of lung volume loss by inhibiting peripheral airway closures might have also contributed to the observed effects of levosimendan on the G and H responses. Interestingly, the ability of levosimendan to prevent MCh-induced elevations in respiratory tissue damping and stiffness is more pronounced than that of the volatile anesthetic agents, where opening the K ATP channels has little (24) or no effect on this lung compartment (17,28). This feature of levosimendan confirms its potent beneficial action on the lung periphery, as outlined above.…”

Section: Systemic Circulatory Effects Of Levosimendanmentioning

confidence: 68%

Levosimendan prevents bronchoconstriction and adverse respiratory tissue mechanical changes in rabbits

Babik

Balogh

Südy

et al. 2017

American Journal of Physiology-Lung Cellular and Molecular Phys

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Levosimendan has a calcium-sensitizing effect in the myocardium and opens ATP-sensitive potassium channels (K) in vascular smooth muscle. Because airway smooth muscle also expresses K, we characterized the protective potential of levosimendan against increased airway and respiratory tissue resistances. Animals were administered levosimendan alone (), levosimendan after pretreatment with a K channel blocker (glibenclamide, ), glibenclamide only (), or solvent alone (dextrose, ). Airway resistance (R), tissue damping, and elastance were determined by forced oscillations under baseline conditions and following provocation tests with intravenous methacholine (MCh). Cardiac output (CO) was assessed by transpulmonary thermodilution. The same sequence of measurements was then repeated during intravenous infusion of levosimendan in and or glucose in and Sham treatments in and had no effect on lung responsiveness. However, levosimendan treatment in elevated CO and inhibited the MCh-induced airway responses [R changes of 87.8 ± 83% (SD) vs. 24.4 ± 16% at 4 μg·kg·min MCh, < 0.001], and in G (35.2 ± 12.7 vs. 25.2 ± 12.9%, < 0.05). The preventive affect of levosimendan against lung constriction vanished in the LG group. Levosimendan exerts a K-mediated potential to prevent bronchoconstriction and may prohibit adverse lung peripheral changes both in the small bronchi and the pulmonary parenchyma. The identification of a further pleiotropic property of levosimendan that is related to the pulmonary system is of particular importance for patients with decreased cardiorespiratory reserves for which simultaneous circulatory support is complemented with prevention of adverse respiratory events.

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The Protective Effects of Volatile Anesthestics Against the Bronchoconstriction Induced by an Allergic Reaction in Sensitized Rabbit Pups

Cited by 14 publications

References 37 publications

Blockade of the cholinergic system during sensitization enhances lung responsiveness to allergen in rats

Blockade of the cholinergic system during sensitization enhances lung responsiveness to allergen in rats

Physiologically variable ventilation reduces regional lung inflammation in a pediatric model of acute respiratory distress syndrome

Levosimendan prevents bronchoconstriction and adverse respiratory tissue mechanical changes in rabbits

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