The Protective Effects of Vitamin E on Urinary Bladder Apoptosis and Oxidative Stress in Streptozotocin-induced Diabetic Rats

Üstüner, Mehmet Cengiz; Kabay, Şahin; Özden, Hilmi; Güven, Gül; Yücel, Mehmet; Olgun, Esra Gurlek; Üstüner, Derya; Unal, Nedim; Değirmenci, İrfan

doi:10.1016/j.urology.2009.06.003

Cited by 15 publications

(11 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This effect, which was more apparent in GSE than in vitamin E, may be occurring because GSE is a strong antioxidative and has greater anti-apoptotic and anti-inflammatory properties. It has been shown in various tissues, other than the brain, that vitamin E also inhibits apoptosis and reduces the number of TUNEL (+) cells in STZ-induced diabetic rats (Ustuner et al, 2010;Kaplanoglu et al, 2013). Apart from these studies, we demonstrated in the present study that vitamin E had a neuroprotective effect on hippocampal pyramidal neurons of STZ-induced diabetic rats.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats

Yonguc

Dodurga

Adıgüzel

et al. 2015

Gene

View full text Add to dashboard Cite

Section: Accepted Manuscriptmentioning

confidence: 99%

Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats

Yonguc

Dodurga

Adıgüzel

et al. 2015

Gene

View full text Add to dashboard Cite

“…Nevertheless, in recent studies 22 using melatonin and a-tocoferol have been shown to protect against bladder damage through scavenging ROS and Reactive Nitrogen Species (RNS). Moreover, a data 23 showed in their results that vitamin E decreases apoptosis and may be protective for uroepithelial cells of diabetic bladder.…”

Section: Discussionmentioning

confidence: 98%

Inhibitory activity of α‐tocoferol on apoptosis in the rat bladder wall subjected to androgen deprivation

Ludwig

Seraphim

Lorenzetti

et al. 2010

Neurourology and Urodynamics

View full text Add to dashboard Cite

Alpha-tocopherol (2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-chromon-8-ol) is used in many previous urological studies. Thus to add to this knowledge in this study we studied the potential inhibitory activity on oxidative stress and process apoptosis on bladder wall in male rats subjected to androgen deprivation. A causal relationship between lower testosterone levels and apoptosis, as a component of castration-induced muscle atrophy, has been shown. Male Wistar rats (250-300 g) were used in this experiment, divided into four groups: control (sham operation; n=10); castration (n=10); castration, with alpha-tocopherol supplementation over preceding four weeks (n=10); and castration, with alpha-tocopherol supplementation over preceding four weeks and subsequent eight weeks (n=10). Activated caspase-3 was detected using a previously described technique, with analysis using stereological methodology. Nonparametric methods were used to test statistical significance, taking a significance level of P<0.005. This study was approved by the ethics committee of the university where the project was developed. The serum testosterone concentrations before castration were less than 20 pg/ml. Analysis of 8-isoprostane showed statistical significance (P<0.0003). The volumetric density of caspase-3 showed significant differences between the groups. There was no statistical significance regarding caspase-3 between sham and alpha-tocopherol plus castration or between the groups that received alpha-tocopherol supplementation. The observations showed that there was greater apoptosis in the group with castration alone than in the groups with alpha-tocopherol supplementation. This finding, together with the induced androgen deprivation and higher 8-isoprostane levels, corroborates the hypothesis that alpha-tocopherol supplementation has an important protective effect under conditions of oxidative stress, thereby avoiding the apoptotic process, especially regarding aging.

show abstract

“…All the cells in HG groups were induced by high glucose/hypoxia (at a glucose concentration of 22.0 mmol/L and 3% O 2 ) with vehicle, a-T (100 mM), a-TP (100 mM), or a-T þ a-TP (100 mM and 100 mM) for 24 hours, respectively. The cells of the NG were incubated with vehicle for 24 hours.…”

Section: Methodsmentioning

confidence: 99%

“…21 A host of studies have confirmed that a-T can exert potent antiapoptotic effects in various cell types, including cortical neurons, urinary bladder, retinal ganglion, and others. [21][22][23] Besides, Kasimanickam et al found that a-T can also promote the role of angiogenesis. 24 In recent years, it has been deduced that small amounts of a-tocopherol phosphate (a-TP) were detected in plasma, tissue, and cultured cells.…”

mentioning

confidence: 99%

α-Tocopherol, especially α-tocopherol phosphate, exerts antiapoptotic and angiogenic effects on rat bone marrow-derived endothelial progenitor cells under high-glucose and hypoxia conditions

Zheng

Meng

et al. 2018

Journal of Vascular Surgery

View full text Add to dashboard Cite

show abstract

The Protective Effects of Vitamin E on Urinary Bladder Apoptosis and Oxidative Stress in Streptozotocin-induced Diabetic Rats

Cited by 15 publications

References 21 publications

Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats

Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats

Inhibitory activity of α‐tocoferol on apoptosis in the rat bladder wall subjected to androgen deprivation

α-Tocopherol, especially α-tocopherol phosphate, exerts antiapoptotic and angiogenic effects on rat bone marrow-derived endothelial progenitor cells under high-glucose and hypoxia conditions

Contact Info

Product

Resources

About